Publication:
One-step injectable and bioreducible poly(beta-amino ester) hydrogels as controlled drug delivery platforms

dc.contributor.coauthorBingol, Betul
dc.contributor.coauthorAltuncu, Seckin
dc.contributor.coauthorGulyuz, Umit
dc.contributor.coauthorOkay, Oguz
dc.contributor.coauthorAvci, Duygu
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAcar, Havva Funda Yağcı
dc.contributor.kuauthorAk, Ayşe
dc.contributor.kuauthorDuman, Fatma Demir
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T22:51:50Z
dc.date.issued2019
dc.description.abstractA one-step synthesis strategy based on aza-Michael reaction of poly(ethylene glycol) diacrylate (PEGDA) or PEGDA/1,6-hexanediol diacrylate (HDDA) mixture and cystamine was employed to fabricate injectable, biocompatible, and degradable novel poly(beta-amino ester) (PBAE) hydrogels. The gelation was monitored by real-time dynamic rheological measurements to follow the formation of PBAE hydrogel networks. The obtained hydrogels were responsive to both pH and redox state, which enabled the control of swelling, degradation, and release properties by external triggers. Degradation products of the hydrogels were shown to have no significant cytotoxicity on A549 adenocarcinomic human alveolar basal epithelial cells and MCF-7 human breast cancer cells. The hydrogels were loaded with a photosensitizer, methylene blue (MB), as a model compound by simple addition of the MB molecules into the precursor mixture. The activity of released MB was assessed by in vitro photodynamic therapy (PDT) studies conducted with A549 cells.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue7
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipBogazici University [13842]
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) National Scholarship Programme for PhD Students [2211-A] The authors would like to acknowledge financial support from Bogazici University Research Fund (13842). B.B. is thankful for the financial support of the Scientific and Technological Research Council of Turkey (TUBITAK) National Scholarship Programme for PhD Students (2211-A).
dc.description.volume1
dc.identifier.doi10.1021/acsapm.9b00287
dc.identifier.issn2637-6105
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85083491891
dc.identifier.urihttps://doi.org/10.1021/acsapm.9b00287
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6920
dc.identifier.wos476967100013
dc.keywordsHydrogel
dc.keywordsBiodegradable polymers
dc.keywordsPoly(beta-amino ester)s
dc.keywordsControlled release
dc.keywordsPhotodynamic therapy aza-michael reaction
dc.keywordsPhotodynamic therapy
dc.keywordsMethylene-blue
dc.keywordsAlpha
dc.keywordsBeta-ethylenic compounds
dc.keywordsAmines
dc.keywordsNetworks
dc.keywordsCancer
dc.keywordsAcid
dc.keywordsPhotosensitizers
dc.keywordsDegradation
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofAcs Applied Polymer Materials
dc.subjectMaterials science
dc.subjectMultidisciplinary
dc.subjectPolymer science
dc.titleOne-step injectable and bioreducible poly(beta-amino ester) hydrogels as controlled drug delivery platforms
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAcar, Havva Funda Yağcı
local.contributor.kuauthorDuman, Fatma Demir
local.contributor.kuauthorAk, Ayşe
local.publication.orgunit1College of Sciences
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Department of Chemistry
local.publication.orgunit2Graduate School of Sciences and Engineering
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relation.isOrgUnitOfPublication3fc31c89-e803-4eb1-af6b-6258bc42c3d8
relation.isOrgUnitOfPublication.latestForDiscovery035d8150-86c9-4107-af16-a6f0a4d538eb
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