Publication:
The brainstem connections of the supplementary motor area and its relations to the corticospinal tract: experimental rat and human 3-tesla tractography study

dc.contributor.coauthorÖzkan, Mazhar
dc.contributor.coauthorGüneş, Yasin Celal
dc.contributor.coauthorAlgın, Oktay
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorAltınöz, Damlasu
dc.contributor.kuauthorÇavdar, Safiye
dc.contributor.kuauthorKöse, Büşra
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:52:22Z
dc.date.issued2023
dc.description.abstractAlthough the supplementary motor area (SMA) is a large region on the medial surface of the frontal lobe of the brain, little is known about its function. The current study uses 3-tesla high-resolution diffusion tensor trac-tography (DTI) in healthy individuals and biotinylated dextran amine (BDA) and fluoro-gold (FG) tracer in rats to demonstrate the afferent and efferent connections of the SMA with brainstem structures. It also aims to clarify how SMA fibers relate to the corticospinal tract (CST). The BDA (n = 6) and FG (n = 8) tracers were pressure-injected into the SMA of 14 Wistar albino rats. Light and fluorescence microscopy was used to capture images of the FG and BDA-labeled cells and axons. High-resolution 3-tesla DTI data were acquired from the Human Connectome Project database. Tracts between the SMA and brainstem structures were analyzed using diffusion spectrum imaging (DSI) studio software. The FG injections into the SMA showed afferent projections from mesencephalic (periaqueductal gray matter, substantia nigra pars reticulata, ventral tegmental area, inferior colliculus, mesencephalic reticular, tegmental, and raphe nuclei), pontine (locus coeruleus, pontine reticular and vestibular nuclei), and medullary (area postrema, parabrachial, and medullary reticular nuclei) structures. The anterograde tracer BDA injections into the SMA showed efferent connections with mesencephalic (peri-aqueductal gray, substantia nigra pars compacta, dorsal raphe, trigeminal motor mesencephalic, and mesence-phalic reticular nuclei), pontine (locus coeruleus, nucleus of the lateral lemniscus, vestibular, cochlear, and pontine reticular nuclei), and medullary (area postrema, medullary reticular, olivary, and parabrachial nuclei) structures. The SMA had efferent but no afferent connections with the cerebellar nuclei. The DTI results in healthy human subjects highly corresponded with the experimental results. Further, the DTI results showed a distinct bundle that descended to spinal levels closely related to the CST. Understanding SMA's afferent and efferent connections will enrich our knowledge of its contribution to various brainstem networks and may provide new perspectives for understanding its motor and non-motor functions.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume798
dc.identifier.doi10.1016/j.neulet.2023.137099
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85147116713
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2023.137099
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7009
dc.identifier.wos927529200001
dc.keywordsSupplementary motor area
dc.keywordsBrainstem
dc.keywordsCorticospinal tract
dc.keywordsMotor function
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofNeuroscience Letters
dc.subjectNeurosciences
dc.titleThe brainstem connections of the supplementary motor area and its relations to the corticospinal tract: experimental rat and human 3-tesla tractography study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÇavdar, Safiye
local.contributor.kuauthorKöse, Büşra
local.contributor.kuauthorAltınöz, Damlasu
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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