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The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence

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dc.contributor.coauthorAfşar, Barış
dc.contributor.coauthorAfşar, Rengin Elsürer
dc.contributor.coauthorSag, Alan A.
dc.contributor.coauthorOrtiz, Alberto
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuprofileResearcher
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid110580
dc.contributor.yokid368625
dc.date.accessioned2024-11-09T23:02:34Z
dc.date.issued2021
dc.description.abstractEnergy restriction (ER) has anti-ageing effects and probably protects from a range of chronic diseases including cancer, diabetes and chronic kidney disease (CKD). Specifically, ER has a positive impact on experimental kidney ageing, CKD (diabetic nephropathy, polycystic kidney disease) and acute kidney injury (nephrotoxic, ischaemia-reperfusion injury) through such mechanisms as increased autophagy, mitochondrial biogenesis and DNA repair, and decreased inflammation and oxidative stress. Key molecules contributing to ER-mediated kidney protection include adenosine monophosphate-activated protein kinase, sirtuin-1 and PPAR-gamma coactivator 1 alpha. However, CKD is a complex condition, and ER may potentially worsen CKD complications such as protein-energy wasting, bone-mineral disorders and impaired wound healing. ER mimetics are drugs, such as metformin and Na-glucose co-transporter-2 which mimic the action of ER. This review aims to provide comprehensive data regarding the effect of ER on CKD progression and outcomes.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue11
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipPresidency of Turkey, Presidency of Strategy and Budget M. K. gratefully acknowledges use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Presidency of Strategy and Budget.
dc.description.volume125
dc.identifier.doi10.1017/S000711452000358X
dc.identifier.eissn1475-2662
dc.identifier.issn0007-1145
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85091829465
dc.identifier.urihttp://dx.doi.org/10.1017/S000711452000358X
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8316
dc.identifier.wos649806900001
dc.keywordsEnergy restriction
dc.keywordsChronic kidney disease
dc.keywordsEnergy restriction mimetics
dc.keywordsAutophagy
dc.keywordsMammalian target of rapamycin pathway term calorie restriction
dc.keywordsIschemia-reperfusion injury
dc.keywordsDietary restriction
dc.keywordsOxidative stress
dc.keywordsRenal-disease
dc.keywordsCarbohydrate restriction
dc.keywordsDiabetic-nephropathy
dc.keywordsWeight-loss
dc.keywordsProtein
dc.keywordsExpression
dc.languageEnglish
dc.publisherCambridge University Press (CUP)
dc.sourceBritish Journal of Nutrition
dc.subjectNutrition & Dietetics
dc.titleThe effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0002-1297-0675
local.contributor.authorid0000-0003-0190-2746
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorKanbay, Mehmet

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