Publication:
Lack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: first report of the IAIHG retrospective registry

dc.contributor.coauthorSlooter, Charlotte D.
dc.contributor.coauthorVan Den Brand, Floris F.
dc.contributor.coauthorLleo, Ana
dc.contributor.coauthorColapietro, Francesca
dc.contributor.coauthorLenzi, Marco
dc.contributor.coauthorMuratori, Paolo
dc.contributor.coauthorKerkar, Nanda
dc.contributor.coauthorDalekos, George N.
dc.contributor.coauthorZachou, Kalliopi
dc.contributor.coauthorLucena, M. Isabel
dc.contributor.coauthorRobles-Díaz, Mercedes
dc.contributor.coauthorDi Zeo-Sánchez, Daniel E.
dc.contributor.coauthorAndrade, Raúl J.
dc.contributor.coauthorMontano-Loza, Aldo J.
dc.contributor.coauthorLytvyak, Ellina
dc.contributor.coauthorLissenberg-Witte, Birgit I.
dc.contributor.coauthorMaisonneuve, Patrick
dc.contributor.coauthorBouma, Gerd
dc.contributor.coauthorMacEdo, Guilherme
dc.contributor.coauthorLiberal, Rodrigo
dc.contributor.coauthorDe Boer, Ynto S.
dc.contributor.coauthorAlmasio, P.
dc.contributor.coauthorAlvarez, F.
dc.contributor.coauthorAndrade, R.
dc.contributor.coauthorAssis, D.
dc.contributor.coauthorBardou-Jacquet, E.
dc.contributor.coauthorBiewenga, M.
dc.contributor.coauthorVan Hoek, B.
dc.contributor.coauthorDe Boer, Y.
dc.contributor.coauthorVan Nieuwkerk, C.
dc.contributor.coauthorCancado, E.
dc.contributor.coauthorCazzagon, N.
dc.contributor.coauthorChazouillères, O.
dc.contributor.coauthorColloredo, G.
dc.contributor.coauthorCuarterolo, M.
dc.contributor.coauthorInes Lopez, S.
dc.contributor.coauthorDalekos, G.
dc.contributor.coauthorGatselis, N.
dc.contributor.coauthorDebray, D.
dc.contributor.coauthorDrenth, J.
dc.contributor.coauthorDyson, J.
dc.contributor.coauthorEfe, C.
dc.contributor.coauthorEngel, B.
dc.contributor.coauthorFerri, S.
dc.contributor.coauthorMuratori, L.
dc.contributor.coauthorFontana, R.
dc.contributor.coauthorGerussi, A.
dc.contributor.coauthorInvernizzi, P.
dc.contributor.coauthorHalilbasic, E.
dc.contributor.coauthorHalliday, N.
dc.contributor.coauthorHeneghan, M.
dc.contributor.coauthorMieli-Vergani, G.
dc.contributor.coauthorHirschfield, G.
dc.contributor.coauthorHørby Jørgensen, M.
dc.contributor.coauthorIndolfini, G.
dc.contributor.coauthorIorio, R.
dc.contributor.coauthorJeong, S.
dc.contributor.coauthorJones, D.
dc.contributor.coauthorKelly, D.
dc.contributor.coauthorLacaille, F.
dc.contributor.coauthorLammert, C.
dc.contributor.coauthorLeggett, B.
dc.contributor.coauthorLevy, C.
dc.contributor.coauthorLohse, A.
dc.contributor.coauthorDe Martin, E.
dc.contributor.coauthorMcLin, V.
dc.contributor.coauthorMilkiewicz, P.
dc.contributor.coauthorMohan, N.
dc.contributor.coauthorNebbia, G.
dc.contributor.coauthorOo, Y.
dc.contributor.coauthorOrtega, A.
dc.contributor.coauthorPáres, A.
dc.contributor.coauthorPop, T.
dc.contributor.coauthorPratt, D.
dc.contributor.coauthorPurnak, T.
dc.contributor.coauthorRanucci, G.
dc.contributor.coauthorRushbrook, S.
dc.contributor.coauthorSchramm, C.
dc.contributor.coauthorStättermayer, A.
dc.contributor.coauthorSwain, M.
dc.contributor.coauthorTanaka, A.
dc.contributor.coauthorTaubert, R.
dc.contributor.coauthorTerrabuio, D.
dc.contributor.coauthorTerziroli, B.
dc.contributor.coauthorTrauner, M.
dc.contributor.coauthorValentino, P.
dc.contributor.coauthorVergani, D.
dc.contributor.coauthorVan Den Brand, F.
dc.contributor.coauthorVierling, J.M.
dc.contributor.coauthorVillamil, A.
dc.contributor.coauthorWahlin, S.
dc.contributor.coauthorYtting, H.
dc.contributor.coauthorZeniya, M.
dc.contributor.coauthorVan Gerven, N.
dc.contributor.coauthorVan Erpecum, K.
dc.contributor.coauthorDen Ouden, J.
dc.contributor.coauthorBrouwer, J.
dc.contributor.coauthorVrolijk, J.
dc.contributor.coauthorGevers, Tom J.G.
dc.contributor.coauthorGuichelaar, M.
dc.contributor.coauthorBouma, G.
dc.contributor.coauthorSchreuder, T.C.M.A.
dc.contributor.coauthorVan Der Wouden, E.J.
dc.contributor.coauthorBaak, L.C.
dc.contributor.coauthorVerdonk, R.
dc.contributor.coauthorVan Der Meer, A.
dc.contributor.coauthorKlemt-Kropp, M.
dc.contributor.coauthorVerhagen, M.
dc.contributor.coauthorBhalla, A.
dc.contributor.coauthorKuijvenhoven, J.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorArıkan, Çiğdem
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:37:38Z
dc.date.issued2024
dc.description.abstractBackground and Aims: The International Autoimmune Hepatitis Group retrospective registry (IAIHG-RR) is a web-based platform with subjects enrolled with a clinical diagnosis of autoimmune hepatitis (AIH). As prognostic factor studies with enough power are scarce, this study aimed to ascertain data quality and identify prognostic factors in the IAIHG-RR cohort. Methods: This retrospective, observational, multicenter study included all patients with a clinical diagnosis of AIH from the IAIHG-RR. The quality assessment consisted of external validation of completeness and consistency for 29 predefined variables. Cox regression was used to identify risk factors for liver-related death and liver transplantation (LT). Results: This analysis included 2559 patients across 7 countries. In 1700 patients, follow-up was available, with a completeness of individual data of 90% (range: 30-100). During a median follow-up period of 10 (range: 0-49) years, there were 229 deaths, of which 116 were liver-related, and 143 patients underwent LT. Non-White ethnicity (HR 4.1 95% CI: 2.3-7.1), cirrhosis (HR 3.5 95% CI: 2.3-5.5), variant syndrome with primary sclerosing cholangitis (PSC) (HR 3.1 95% CI: 1.6-6.2), and lack of complete biochemical response within 6 months (HR 5.7 95% CI: 3.4-9.6) were independent prognostic factors. Conclusions: The IAIHG-RR represents the world's largest AIH cohort with moderate-to-good data quality and a relevant number of liver-related events. The registry is a suitable platform for patient selection in future studies. Lack of complete biochemical response to treatment, non-White ethnicity, cirrhosis, and PSC-AIH were associated with liver-related death and LT. © 2023 American Association for the Study of Liver Diseases.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipAna Lleo received research grants from the Italian Foundation for Cancer Research (AIRC) and the Italian Ministry of Health. The International Autoimmune Hepatitis Group (IAIHG) retrospective registry was funded by the United European Gastroenterology LINK award (2015).
dc.description.volume79
dc.identifier.doi10.1097/HEP.0000000000000589
dc.identifier.eissn1527-3350
dc.identifier.issn0270-9139
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85185343173
dc.identifier.urihttps://doi.org/10.1097/HEP.0000000000000589
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22433
dc.identifier.wos1138428300001
dc.keywordsCholangitis
dc.keywordsSclerosing
dc.keywordsHepatitis
dc.keywordsAutoimmune
dc.keywordsHumans
dc.keywordsLiver cirrhosis
dc.keywordsLiver transplantation
dc.keywordsPathologic complete response
dc.keywordsRetrospective studies
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofHepatology
dc.subjectGastroenterology and hepatology
dc.titleLack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: first report of the IAIHG retrospective registry
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorArıkan, Çiğdem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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