Publication: Relationship of metabolic alterations and PD-L1 expression in cisplatin resistant lung cancer
Program
KU-Authors
KU Authors
Co-Authors
Wangpaichitr M
Li YY
Wu C
Nguyen D
Feun LG
Kuo MT
Savaraj N.
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Embargo Status
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Abstract
Despite numerous reports on immune checkpoint inhibitor for the treatment of non-small cell lung cancer (NSCLC), the response rate remains low but durable. Thus cisplatin still plays a major role in the treatment of NSCLC. While there are many mechanisms involved in cisplatin resistance, alteration in metabolic phenotypes with elevated levels of reactive oxygen species (ROS) are found in several cisplatin resistant tumors. These resistant cells become more reliant on mitochondria oxidative metabolism instead of glucose. Consequently, high ROS and metabolic alteration contributed to epithelial-mesenchymal transition (EMT). Importantly, recent findings indicated that EMT has a crucial role in upregulating PD-L1 expression in cancer cells. Thus, it is very likely that cisplatin resistance will lead to high expression of PD-L1/PD-1 which makes them vulnerable to anti PD-1 or anti PD-L1 antibody treatment. An understanding of the interactions between cancer cells metabolic reprogramming and immune checkpoints is critical for combining metabolism targeted therapies with immunotherapies.
Source
Publisher
OMICS Publishing Group
Subject
Medicine
Citation
Has Part
Source
Cell and developmental biology
Book Series Title
Edition
DOI
10.4172/2168-9296.1000183