Publication:
The effect of transcranial direct current stimulation on seizure frequency of patients with mesial temporal lobe epilepsy with hippocampal sclerosis

dc.contributor.coauthorTekturk, Pinar
dc.contributor.coauthorErdogan, Ezgi Tuna
dc.contributor.coauthorKurt, Adnan
dc.contributor.coauthorEkizoglu, Esme
dc.contributor.coauthorKocagoncu, Ece
dc.contributor.coauthorKucuk, Zeynep
dc.contributor.coauthorAksu, Serkan
dc.contributor.coauthorBebek, Nerses
dc.contributor.coauthorYapici, Zuhal
dc.contributor.coauthorGurses, Candan
dc.contributor.coauthorGokyigit, Aysen
dc.contributor.coauthorBaykan, Betul
dc.contributor.coauthorKaramursel, Sacit
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorVanlı-Yavuz, Ebru Nur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:56:32Z
dc.date.issued2016
dc.description.abstractObjectives: Transcranial direct current stimulation (tDCS) is a non-invasive and safe method tried in drug resistant epilepsies, in recent years. Our aim was to evaluate the effect of tDCS in patients diagnosed with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) which is a well-known drug resistant focal epilepsy syndrome. Patients and Methods: Twelve MTLE-HS patients diagnosed with their typical clinical, EEG and MRI findings fulfilling the criteria for drug-resistance as suggested by the ILAE commission were included after Ethics Committee approval and their signed consent. All patients received modulated cathodal stimulation; 2 mA for 30 min on 3 consecutive days. All patients also received sham stimulation with the same electrode positions; designed as 60 s stimulation gradually decreasing in 15 s with placement of the electrodes for 30 min over the stimulation side. They were followed up by standard seizure diaries and their medical treatment was not changed during the study period. Their seizure frequencies both before and after cathodal tDCS and sham stimulation were compared statistically. Adverse effects were also questioned. Results: Mean age of our study group was 35.42 +/- 6.96 (6 males; median: 35.50). The mean seizure frequency was 10.58 +/- 9.91 (median = 8; min-max = 2-30) at the baseline and significantly decreased to 1.67 +/- 2.50 (median = 0.5; min-max = 0-8) after cathodal tDCS application (p = 0.003). Ten patients (83.33%) had more than 50% decrease in their seizure frequencies after cathodal tDCS. Two patients (16.67%) also showed positive sham effect. Six patients (50%) were seizure-free in the post-cathodal tDCS period of one month. No adverse effect has been reported except tingling sensation during cathodal stimulation. Conclusion: Our small series suggested that cathodal tDCS may be used as an additional treatment option in MTLE-HS. It may be tried in TLE-HS patients waiting for or rejecting epilepsy surgery or even with ineffective surgery results. More studies are needed with large series of patients to investigate the effects of tDCS in drug resistant epilepsies.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipTUBITAK1001 Project [113S302] The authors disclose that this work was partially supported by TUBITAK1001 Project Number 113S302.
dc.description.volume149
dc.identifier.doi10.1016/j.clineuro.2016.07.014
dc.identifier.eissn1872-6968
dc.identifier.issn0303-8467
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-84978759661
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2016.07.014
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7387
dc.identifier.wos383826500006
dc.keywordsTranscranial direct current stimulation (Tdcs)
dc.keywordsTemporal lobe epilepsy
dc.keywordsHippocampal sclerosis
dc.keywordsDrug resistant epilepsy
dc.keywordsCathodal tdcs
dc.keywordsModulated tdcs electrical-stimulation
dc.keywordsCortical excitability
dc.keywordsEpileptiform activity
dc.keywordsPrefrontal cortex
dc.keywordsBrain-stimulation
dc.keywordsModulation
dc.keywordsMechanisms
dc.keywordsPlasticity
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofClinical Neurology and Neurosurgery
dc.subjectClinical neuropsychology
dc.subjectSurgery
dc.titleThe effect of transcranial direct current stimulation on seizure frequency of patients with mesial temporal lobe epilepsy with hippocampal sclerosis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorVanlı-Yavuz, Ebru Nur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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