Publication: The potential for emerging microbiome-mediated therapeutics in asthma
dc.contributor.coauthor | Turturice, Benjamin Arthur | |
dc.contributor.coauthor | Perkins, David L. | |
dc.contributor.coauthor | Finn, Patricia W. | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Öztürk, Ayşe Bilge | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:53:08Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Purpose of Review In terms of immune regulating functions, analysis of the microbiome has led the development of therapeutic strategies that may be applicable to asthma management. This review summarizes the current literature on the gut and lung microbiota in asthma pathogenesis with a focus on the roles of innate molecules and new microbiome-mediated therapeutics. Recent Findings Recent clinical and basic studies to date have identified several possible therapeutics that can target innate immunity and the microbiota in asthma. Some of these drugs have shown beneficial effects in the treatment of certain asthma phenotypes and for protection against asthma during early life. Summary Current clinical evidence does not support the use of these therapies for effective treatment of asthma. The integration of the data regarding microbiota with technologic advances, such as next generation sequencing and omics offers promise. Combining comprehensive bioinformatics, new molecules and approaches may shape future asthma treatment. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 9 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Turkish Thoracic Society Fellowship Programme Dr. Öztürk would like to thank the Turkish Thoracic Society Fellowship Programme for supporting her work at the UIC Department of Medicine Finn-Perkins Laboratory. | |
dc.description.volume | 17 | |
dc.identifier.doi | 10.1007/s11882-017-0730-1 | |
dc.identifier.eissn | 1534-6315 | |
dc.identifier.issn | 1529-7322 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85027863993 | |
dc.identifier.uri | https://doi.org/10.1007/s11882-017-0730-1 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/14966 | |
dc.identifier.wos | 410900800005 | |
dc.keywords | Asthma | |
dc.keywords | Innate immunity | |
dc.keywords | Interleukin-33 | |
dc.keywords | Microbiota | |
dc.keywords | Thymic stromal lymphopoietin | |
dc.keywords | Toll-like receptors | |
dc.language.iso | eng | |
dc.publisher | Current Medicine Group | |
dc.relation.ispartof | Current Allergy and Asthma Reports | |
dc.subject | Allergy | |
dc.subject | Immunology | |
dc.title | The potential for emerging microbiome-mediated therapeutics in asthma | |
dc.type | Review | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Öztürk, Ayşe Bilge | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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