Publication: The effect of montelukast on early-life wheezing: a randomized, double-blinded placebo-controlled study
Program
KU-Authors
KU Authors
Co-Authors
Keskin, Özlem
Yılmaz, Ebru Arık
Motzkus, Christine
Lilly, Craig M.
Kalaycı, Ömer
Publication Date
Language
Type
Embargo Status
Journal Title
Journal ISSN
Volume Title
Alternative Title
Abstract
Background: Cysteinyl-leukotrienes are increased in the airways of infants with virus-associated wheezing. We aimed to determine the effects of a cysteinyl-leukotriene-1 receptor antagonist on symptoms during an early-life wheezing illness and to investigate the factors that affect the response to this drug. Method: This placebo-controlled double-blinded randomized controlled trial recruited children aged 3-36 months with wheezing illness and randomized to active drug or placebo for 56 days. A symptom score diary (SSD) was kept by the children's caregivers. Results: One-hundred patients completed the study, and 62 (30 montelukast and 32 placebo) were analyzed. There were no significant differences in the percent of symptom-free days, symptom scores, and the need for rescue salbutamol between the two groups. However, the percent of symptom-free days within the first week was significantly higher for the montelukast than for the placebo group (13.8 +/- 4.1% vs. 5.4 +/- 3.4%; P = 0.028); wheezing score at 7th day was significantly lower for the montelukast than for the placebo group (0.5 +/- 0.1 vs. 1.4 +/- 0.2; P = 0.002). In addition, the number of inhaled ss 2-agonist rescue episodes per day during the first week was significantly lower for the montelukast compared with the placebo group (12.7 +/- 1.8 vs. 19.2 +/- 1.6; P = 0.013). Conclusions: Our results indicate that montelukast may be effective for reducing caregiver-observed wheezing and the need for salbutamol during the first week of treatment for early-life wheezing. The impact for caregivers and the optimal duration of treatment will need to be explored in studies of larger size.
Source
Publisher
Wiley
Subject
Allergy, Immunology, Pediatrics
Citation
Has Part
Source
Pediatric Allergy and Immunology
Book Series Title
Edition
DOI
10.1111/pai.12822