Publication:
Dietary and commercialized fructose: sweet or sour?

dc.contributor.coauthorKing, Christopher
dc.contributor.coauthorKuwabara, Masanari
dc.contributor.coauthorLanaspa, Miguel A.
dc.contributor.coauthorAndres-Hernando, Ana
dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorManitius, Jacek
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorDağel, Tuncay
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorSağ, Alan Alper
dc.contributor.kuauthorYerlikaya, Aslıhan
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:56:00Z
dc.date.issued2017
dc.description.abstractMetabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Concurrent increase in both fructose consumption with Western diet and metabolic syndrome has revealed fructose hypothesis that suggests fructose as one of etiological factor of metabolic syndrome (insulin resistance, central obesity, hypertension, etc.). Recent studies have increasingly lightened the unknowns about role of fructose on pathogenesis. This review discusses fructose hypothesis by exploring current studies and their results in wide perspective. Potential mechanisms covering low-grade inflammation or de novo lipogenesis, etc., in the development of insulin resistance and obesity are explained. Clinical trials have revealed connection of fructose-induced hyperuricemia with insulin resistance and chronic inflammatory state leading to hepatosteatosis or obesity. Further, novel hypothesizes suggesting role of fructose-induced modifications in epigenetics, gut microbiota and oxidative stress on disease pathogenesis are reviewed based on recent clinical trials. More innovative theories including fructose-induced malignancy; decreased satiety feeling, and unfavorable bone health are argued covering fructose-induced neurotransmitter changes in central nervous system, more aggressive malignancy phenotype and impaired calcium absorption.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume49
dc.identifier.doi10.1007/s11255-017-1544-8
dc.identifier.eissn1573-2584
dc.identifier.issn0301-1623
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85013102402
dc.identifier.urihttps://doi.org/10.1007/s11255-017-1544-8
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7295
dc.identifier.wos407739600013
dc.keywordsFructose
dc.keywordsCardiovascular disease
dc.keywordsKidney disease
dc.keywordsObesity
dc.keywordsHypertension
dc.keywordsSerum uric-acid
dc.keywordsChronic kidney-disease
dc.keywordsMetabolic syndrome
dc.keywordsCorn syrup
dc.keywordsHypertensive patients
dc.keywordsGut microbiota
dc.keywordsBlood-pressure
dc.keywordsRenal-function
dc.keywordsFatty-liver
dc.keywordsPpar-alpha
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.subjectUrology
dc.subjectNephrology
dc.titleDietary and commercialized fructose: sweet or sour?
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorYerlikaya, Aslıhan
local.contributor.kuauthorSağ, Alan Alper
local.contributor.kuauthorDağel, Tuncay
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
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