Publication:
PSA change after antibiotic treatment should not affect decision-making on performing a prostate biopsy

dc.contributor.coauthorKayali, Yunus
dc.contributor.coauthorIlktac, Abdullah
dc.contributor.coauthorErsoz, Cevper
dc.contributor.coauthorToprak, Hueseyin
dc.contributor.coauthorAkcay, Muzaffer
dc.contributor.coauthorDogan, Bayram
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBalbay, Mevlana Derya
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.kuauthorTarım, Kayhan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:52:23Z
dc.date.issued2023
dc.description.abstractBackground/aim: To investigate the effect of antibiotic treatment on PSA when deciding on prostate biopsy.Materials and methods: A total of 206 patients with an elevated PSA level (2.5-30) were included. Mp-MRI could be done on 129 patients. Patients were given ciprofloxacin (500 mg, b.i.d. p.o.) for 4 weeks and PSA measurements were repeated. Systematic prostate biopsy was performed regardless of PSA changes on all patients. Additionally, cognitive biopsies were performed from PI-RADs III, IV, and V lesions.Results: Prostate cancer was detected in 36.4% of patients. 53.3% had Gleason score of 3+3, 46.7% had Gleason score >= 3+4. PSA values decreased in 56.3% and in 43.7% and remained the same or increased but cancer detection rates were not different: 34.5% vs. 38.9%, respectively (p = 0.514). PSA change in whole group was significant (6.38 ng/mL vs. 5.95 ng/mL, respectively (p = 0.01). No significant PSA decrease was observed in cancer patients (7.1 ng/mL vs. 7.05 ng/mL, p = 0.09), whereas PSA decrease was significant in patients with benign pathology (6.1 ng/mL vs. 5.5 ng/mL, p = 0.01). In patients with PI-RADs IV-V lesions, adenocarcinoma was present in 33.9% and 30.4% with or without PSA decrease, respectively (p = 0.209). Clinically significant cancer was higher in patients with after antibiotherapy PSA values >4 ng/mL regardless of PI-RADs grouping (p = 0.08). Addition of any PSA value to PI-RADs grouping did not have any significant effect on the detection of cancer.Conclusion: PSA change after antibiotic treatment has no effect in detecting cancer and should not delay performing a biopsy.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyTR Dizin
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume53
dc.identifier.doi10.55730/1300-0144.5571
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85149131458
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5571
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14850
dc.identifier.wos941667500021
dc.keywordsAntibacterial agents
dc.keywordsMultiparametric magnetic resonance imaging
dc.keywordsProstate cancer
dc.keywordsProstate-specific antigen
dc.language.isoeng
dc.publisherTÜBİTAK 
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.subjectMedicine
dc.subjectGeneral
dc.subjectInternal
dc.titlePSA change after antibiotic treatment should not affect decision-making on performing a prostate biopsy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBalbay, Mevlana Derya
local.contributor.kuauthorTarım, Kayhan
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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