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PSA change after antibiotic treatment should not affect decision-making on performing a prostate biopsy

dc.contributor.coauthorKayali, Yunus
dc.contributor.coauthorIlktac, Abdullah
dc.contributor.coauthorErsoz, Cevper
dc.contributor.coauthorToprak, Hueseyin
dc.contributor.coauthorAkcay, Muzaffer
dc.contributor.coauthorDogan, Bayram
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBalbay, Mevlana Derya
dc.contributor.kuauthorTarım, Kayhan
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileResearcher
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.yokid153320
dc.contributor.yokid327605
dc.contributor.yokid272290
dc.date.accessioned2024-11-09T23:52:23Z
dc.date.issued2023
dc.description.abstractBackground/aim: To investigate the effect of antibiotic treatment on PSA when deciding on prostate biopsy.Materials and methods: A total of 206 patients with an elevated PSA level (2.5-30) were included. Mp-MRI could be done on 129 patients. Patients were given ciprofloxacin (500 mg, b.i.d. p.o.) for 4 weeks and PSA measurements were repeated. Systematic prostate biopsy was performed regardless of PSA changes on all patients. Additionally, cognitive biopsies were performed from PI-RADs III, IV, and V lesions.Results: Prostate cancer was detected in 36.4% of patients. 53.3% had Gleason score of 3+3, 46.7% had Gleason score >= 3+4. PSA values decreased in 56.3% and in 43.7% and remained the same or increased but cancer detection rates were not different: 34.5% vs. 38.9%, respectively (p = 0.514). PSA change in whole group was significant (6.38 ng/mL vs. 5.95 ng/mL, respectively (p = 0.01). No significant PSA decrease was observed in cancer patients (7.1 ng/mL vs. 7.05 ng/mL, p = 0.09), whereas PSA decrease was significant in patients with benign pathology (6.1 ng/mL vs. 5.5 ng/mL, p = 0.01). In patients with PI-RADs IV-V lesions, adenocarcinoma was present in 33.9% and 30.4% with or without PSA decrease, respectively (p = 0.209). Clinically significant cancer was higher in patients with after antibiotherapy PSA values >4 ng/mL regardless of PI-RADs grouping (p = 0.08). Addition of any PSA value to PI-RADs grouping did not have any significant effect on the detection of cancer.Conclusion: PSA change after antibiotic treatment has no effect in detecting cancer and should not delay performing a biopsy.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyTR Dizin
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume53
dc.identifier.doi10.55730/1300-0144.5571
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85149131458
dc.identifier.urihttp://dx.doi.org/10.55730/1300-0144.5571
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14850
dc.identifier.wos941667500021
dc.keywordsAntibacterial agents
dc.keywordsMultiparametric magnetic resonance imaging
dc.keywordsProstate cancer
dc.keywordsProstate-specific antigen
dc.languageEnglish
dc.publisherTÜBİTAK 
dc.sourceTurkish Journal of Medical Sciences
dc.subjectMedicine
dc.subjectGeneral
dc.subjectInternal
dc.titlePSA change after antibiotic treatment should not affect decision-making on performing a prostate biopsy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-9706-1587
local.contributor.authorid0000-0002-6071-1539
local.contributor.authorid0000-0003-0392-6709
local.contributor.kuauthorBalbay, Mevlana Derya
local.contributor.kuauthorTarım, Kayhan
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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