Publication:
Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis

dc.contributor.coauthorAppadurai, Vivek
dc.contributor.coauthorChen, Chia-Yen
dc.contributor.coauthorOngur, Dost
dc.contributor.coauthorPizzagalli, Diego A.
dc.contributor.coauthorWerge, Thomas
dc.contributor.coauthorHall, Mei-Hua
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorEren, Candan Yasemin
dc.contributor.kuauthorEser, Hale Yapıcı
dc.contributor.kuauthorDereli, Dilek Yazıcı
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:46:44Z
dc.date.issued2020
dc.description.abstractBackground: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis. Methods: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis. Results: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis. Conclusion: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipNational Institute of Mental Health (NIMH) [R37 MH068376, K24MH104449]
dc.description.sponsorshipNIMH [5R01MH109687]
dc.description.sponsorshipLundbeck Foundation [R102-A9118, R155-2014-1724] DAP was partially supported by National Institute of Mental Health (NIMH) grant no. R37 MH068376. DO was supported by grant no. K24MH104449. MHHwas supported by NIMH grant no. 5R01MH109687. The funder has no role in the design and conduct of the study
dc.description.sponsorshipcollection, management, analysis and interpretation of the data
dc.description.sponsorshippreparation, review or approval of the manuscript
dc.description.sponsorshipor the decision to submit the manuscript for publication. iPSYCH is funded by the Lundbeck Foundation (grant nos. R102-A9118 and R155-2014-1724).
dc.description.volume32
dc.identifier.doi10.1017/neu.2020.14
dc.identifier.issn1601-5215
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85082338231
dc.identifier.urihttps://doi.org/10.1017/neu.2020.14
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14002
dc.identifier.wos581753800007
dc.keywordsGLP-1
dc.keywordsPolymorphism
dc.keywordsAnhedonia
dc.keywordsReward
dc.keywordsDepression
dc.language.isoeng
dc.publisherCambridge University Press (CUP)
dc.relation.ispartofActa Neuropsychiatrica
dc.subjectNeurosciences
dc.subjectPsychiatry
dc.titleAssociation between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorEser, Hale Yapıcı
local.contributor.kuauthorEren, Candan Yasemin
local.contributor.kuauthorYazıcı, Dilek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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