Publication: Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis
dc.contributor.coauthor | Appadurai, Vivek | |
dc.contributor.coauthor | Chen, Chia-Yen | |
dc.contributor.coauthor | Ongur, Dost | |
dc.contributor.coauthor | Pizzagalli, Diego A. | |
dc.contributor.coauthor | Werge, Thomas | |
dc.contributor.coauthor | Hall, Mei-Hua | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Eren, Candan Yasemin | |
dc.contributor.kuauthor | Eser, Hale Yapıcı | |
dc.contributor.kuauthor | Dereli, Dilek Yazıcı | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:46:44Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Background: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis. Methods: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis. Results: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis. Conclusion: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 4 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | National Institute of Mental Health (NIMH) [R37 MH068376, K24MH104449] | |
dc.description.sponsorship | NIMH [5R01MH109687] | |
dc.description.sponsorship | Lundbeck Foundation [R102-A9118, R155-2014-1724] DAP was partially supported by National Institute of Mental Health (NIMH) grant no. R37 MH068376. DO was supported by grant no. K24MH104449. MHHwas supported by NIMH grant no. 5R01MH109687. The funder has no role in the design and conduct of the study | |
dc.description.sponsorship | collection, management, analysis and interpretation of the data | |
dc.description.sponsorship | preparation, review or approval of the manuscript | |
dc.description.sponsorship | or the decision to submit the manuscript for publication. iPSYCH is funded by the Lundbeck Foundation (grant nos. R102-A9118 and R155-2014-1724). | |
dc.description.volume | 32 | |
dc.identifier.doi | 10.1017/neu.2020.14 | |
dc.identifier.issn | 1601-5215 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85082338231 | |
dc.identifier.uri | https://doi.org/10.1017/neu.2020.14 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/14002 | |
dc.identifier.wos | 581753800007 | |
dc.keywords | GLP-1 | |
dc.keywords | Polymorphism | |
dc.keywords | Anhedonia | |
dc.keywords | Reward | |
dc.keywords | Depression | |
dc.language.iso | eng | |
dc.publisher | Cambridge University Press (CUP) | |
dc.relation.ispartof | Acta Neuropsychiatrica | |
dc.subject | Neurosciences | |
dc.subject | Psychiatry | |
dc.title | Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Eser, Hale Yapıcı | |
local.contributor.kuauthor | Eren, Candan Yasemin | |
local.contributor.kuauthor | Yazıcı, Dilek | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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