Publication: Electrical stimulation of neurons with quantum dots via near-infrared light
dc.contributor.department | Department of Electrical and Electronics Engineering | |
dc.contributor.department | Graduate School of Health Sciences | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Eren, Güncem Özgün | |
dc.contributor.kuauthor | Kaleli, Humeyra Nur | |
dc.contributor.kuauthor | Karatüm, Onuralp | |
dc.contributor.kuauthor | Nizamoğlu, Sedat | |
dc.contributor.kuauthor | Şahin, Afsun | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF HEALTH SCIENCES | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T11:54:20Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Photovoltaic biointerfaces offer wireless and battery-free bioelectronic medicine via photomodulation of neurons. Near-infrared (NIR) light enables communication with neurons inside the deep tissue and application of high photon flux within the ocular safety limit of light exposure. For that, nonsilicon biointerfaces are highly demanded for thin and flexible operation. Here, we devised a flexible quantum dot (QD)-based photovoltaic biointerface that stimulates cells within the spectral tissue transparency window by using MR light (lambda = 780 nm). Integration of an ultrathin QD layer of 25 nm into a multilayered photovoltaic architecture enables transduction of NIR light to safe capacitive ionic currents that leads to reproducible action potentials on primary hippocampal neurons with high success rates. The biointerfaces exhibit low in vitro toxicity and robust photoelectrical performance under different stability tests. Our findings show that colloidal quantum dots can be used in wireless bioelectronic medicine for brain, heart, and retina. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 5 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | EU | |
dc.description.sponsorship | European Research Council (ERC) | |
dc.description.sponsorship | European Union (EU) | |
dc.description.sponsorship | Horizon 2020 | |
dc.description.sponsorship | Research and Innovation Programme | |
dc.description.version | Publisher version | |
dc.description.volume | 16 | |
dc.identifier.doi | 10.1021/acsnano.2c01989 | |
dc.identifier.eissn | 1936-086X | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR03638 | |
dc.identifier.issn | 1936-0851 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85130040933 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/795 | |
dc.identifier.wos | 821191000001 | |
dc.keywords | Near-infrared | |
dc.keywords | Neural stimulation | |
dc.keywords | Optical stimulation | |
dc.keywords | Quantum dot | |
dc.keywords | Photovoltaic | |
dc.keywords | Electrical stimulation | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.grantno | 639846 | |
dc.relation.ispartof | ACS Nano | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10493 | |
dc.subject | Chemistry | |
dc.subject | Science and technology | |
dc.subject | Other topics | |
dc.subject | Materials science | |
dc.title | Electrical stimulation of neurons with quantum dots via near-infrared light | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Karatüm, Onuralp | |
local.contributor.kuauthor | Kaleli, Humeyra Nur | |
local.contributor.kuauthor | Eren, Güncem Özgün | |
local.contributor.kuauthor | Şahin, Afsun | |
local.contributor.kuauthor | Nizamoğlu, Sedat | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | GRADUATE SCHOOL OF HEALTH SCIENCES | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | Department of Electrical and Electronics Engineering | |
local.publication.orgunit2 | School of Medicine | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
local.publication.orgunit2 | Graduate School of Health Sciences | |
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