Curcumin-impregnated drug delivery systems may show promise in the treatment of diseases secondary to traumatic brain injury: systematic review

Abstract

ObjectiveTo find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI). MethodsA comprehensive and systematic literature search in the PubMed electronic database was performed. Descriptive statistics were used to evaluate the data obtained. The results were presented as frequency and percentage (%) or amount. ResultsTwo clinical trials investigated curcumin for the treatment of TBI. One study tested curcumin in living mammalian subjects using an amyloLipid nanovesicle. In three studies, curcumin was investigated together with the drug delivery system for the treatment of TBI. ConclusionDrug delivery systems prepared with nanomaterials may have a potential therapeutic effect in treating TBI by increasing neuroprotection because they can penetrate the central nervous system more rapidly.