Publication:
Fundus topographical distribution patterns of ocular toxoplasmosis

dc.contributor.coauthorHalim, Muhammad Sohail
dc.contributor.coauthorÖzdal, Pınar Çakar
dc.contributor.coauthorOrmaechea, Maria Soledad
dc.contributor.coauthorÖzdemir, Hüseyin Baran
dc.contributor.coauthorUludag, Gunay
dc.contributor.coauthorSredar, Nripun
dc.contributor.coauthorCankurtaran, Mahmut
dc.contributor.coauthorLiu, Xiaoxuan
dc.contributor.coauthorDenniston, Alastair Keith
dc.contributor.coauthorRudzinski, Marcelo N.
dc.contributor.coauthorColombero, Daniel N.
dc.contributor.coauthorSchlaen, Bernardo Ariel
dc.contributor.coauthorKeane, Pearse Andrew
dc.contributor.coauthorPavesio, Carlos
dc.contributor.coauthorNguyen, Quan Dong
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorHasanreisoğlu, Murat
dc.contributor.kuauthorKesim, Cem
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:09:34Z
dc.date.issued2023
dc.description.abstractBackground: to establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions. Methods: in this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1 degrees)/recurrent (2 degrees) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed. Results984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1 degrees and 2 degrees lesions was 5.96 +/- 12.26 and 5.21 +/- 12.77 mm(2), respectively. For the subset group lesions (eyes with both 1 degrees and 2 degrees lesions), 1 degrees lesions were significantly larger than 2 degrees lesions (5.52 +/- 6.04 mm(2) vs 4.09 +/- 8.90 mm(2), p=0.038). Mean distances from foveola to 1 degrees and 2 degrees lesion centres were 6336 +/- 4267 and 5763 +/- 3491 mu m, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 mu m inferotemporal to foveola. Conclusion: the 1 degrees lesions were larger than 2 degrees lesions. The 2 degrees lesions were not significantly closer to fovea than 1 degrees lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.
dc.description.indexedbyWOS
dc.description.indexedbyPubMed
dc.description.issue-
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume-
dc.identifier.doi10.1136/bjo-2022-322747
dc.identifier.eissn1468-2079
dc.identifier.issn0007-1161
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85188760558
dc.identifier.urihttps://doi.org/10.1136/bjo-2022-322747
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9327
dc.identifier.wos957156300001
dc.keywordsRetina
dc.keywordsInflammation
dc.keywordsInfection
dc.keywordsImaging
dc.keywordsChoroid
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofThe British Journal of Ophthalmology
dc.subjectOphthalmology
dc.titleFundus topographical distribution patterns of ocular toxoplasmosis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorHasanreisoğlu, Murat
local.contributor.kuauthorKesim, Cem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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