Publication:
Exploring adiposity and chronic kidney disease: clinical implications, management strategies, and prognostic considerations

dc.contributor.coauthorBurlacu, Alexandru
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorÖzbek, Laşin
dc.contributor.kuauthorAbdel-Rahman, Sama Mahmoud
dc.contributor.kuauthorÜnlü, Selen
dc.contributor.kuauthorGüldan, Mustafa
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorCovic, Adrian
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:59:28Z
dc.date.issued2024
dc.description.abstractObesity poses a significant and growing risk factor for chronic kidney disease (CKD), requiring comprehensive evaluation and management strategies. This review explores the intricate relationship between obesity and CKD, emphasizing the diverse phenotypes of obesity, including sarcopenic obesity and metabolically healthy versus unhealthy obesity, and their differential impact on kidney function. We discuss the epidemiological evidence linking elevated body mass index (BMI) with CKD risk while also addressing the paradoxical survival benefits observed in obese CKD patients. Various measures of obesity, such as BMI, waist circumference, and visceral fat assessment, are evaluated in the context of CKD progression and outcomes. Mechanistic insights into how obesity promotes renal dysfunction through lipid metabolism, inflammation, and altered renal hemodynamics are elucidated, underscoring the role of adipokines and the renin-angiotensin-aldosterone system. Furthermore, the review examines current strategies for assessing kidney function in obese individuals, including the strengths and limitations of filtration markers and predictive equations. The management of obesity and associated comorbidities like arterial hypertension, type 2 diabetes mellitus, and non-alcoholic fatty liver disease in CKD patients is discussed. Finally, gaps in the current literature and future research directions aimed at optimizing the management of obesity-related CKD are highlighted, emphasizing the need for personalized therapeutic approaches to mitigate the growing burden of this intertwined epidemic.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.3390/medicina60101668
dc.identifier.eissn1648-9144
dc.identifier.issn1010-660X
dc.identifier.issue10
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85207666615
dc.identifier.urihttps://doi.org/10.3390/medicina60101668
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27716
dc.identifier.volume60
dc.identifier.wos1343118700001
dc.keywordsObesity
dc.keywordsSarcopenic obesity
dc.keywordsVisceral adiposity
dc.keywordsKidney function
dc.keywordsGlomerular filtration rate
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofMedicina (Lithuania)
dc.subjectMedicine
dc.titleExploring adiposity and chronic kidney disease: clinical implications, management strategies, and prognostic considerations
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÖzbek, Laşin
local.contributor.kuauthorAbdel-Rahman, Sama Mahmoud
local.contributor.kuauthorÜnlü, Selen
local.contributor.kuauthorGüldan, Mustafa
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorCovic, Adrian
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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