Publication:
Sex, aging and immunity in multiple sclerosis and experimental autoimmune encephalomyelitis: an intriguing interaction

dc.contributor.coauthorBoziki, Marina
dc.contributor.coauthorTheotokis, Paschalis
dc.contributor.coauthorKesidou, Evangelia
dc.contributor.coauthorKarafoulidou, Eleni
dc.contributor.coauthorKonstantinou, Chrystalla
dc.contributor.coauthorMichailidou, Iliana
dc.contributor.coauthorBahar, Yasemin
dc.contributor.coauthorGrigoriadis, Nikolaos
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAltıntaş, Ayşe
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:59:50Z
dc.date.issued2023
dc.description.abstractMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with a profound neurodegenerative component early in the disease pathogenesis. Age is a factor with a well-described effect on the primary disease phenotype, namely, the relapsing-remitting vs. the primary progressive disease. Moreover, aging is a prominent factor contributing to the transition from relapsing-remitting MS (RRMS) to secondary progressive disease. However, sex also seems to, at least in part, dictate disease phenotype and evolution, as evidenced in humans and in animal models of the disease. Sex-specific gene expression profiles have recently elucidated an association with differential immunological signatures in the context of experimental disease. This review aims to summarize current knowledge stemming from experimental autoimmune encephalomyelitis (EAE) models regarding the effects of sex, either independently or as a factor combined with aging, on disease phenotype, with relevance to the immune system and the CNS. Copyright © 2023 Boziki, Theotokis, Kesidou, Karafoulidou, Konstantinou, Michailidou, Bahar, Altintas and Grigoriadis.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyWOS
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume13
dc.identifier.doi10.3389/fneur.2022.1104552
dc.identifier.issn1664-2295
dc.identifier.scopus2-s2.0-85146891034
dc.identifier.urihttps://doi.org/10.3389/fneur.2022.1104552
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7965
dc.identifier.wos916774100001
dc.keywordsAging
dc.keywordsExperimental autoimmune encephalomyelitis
dc.keywordsProgressive multiple sclerosis
dc.keywordsRelapsing-remitting multiple sclerosis
dc.keywordsSex
dc.language.isoeng
dc.publisherFrontiers Media S.A.
dc.relation.ispartofFrontiers in Neurology
dc.subjectMultiple sclerosis
dc.subjectPregnancy
dc.subjectExperimental autoimmune encephalomyelitis
dc.titleSex, aging and immunity in multiple sclerosis and experimental autoimmune encephalomyelitis: an intriguing interaction
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAltıntaş, Ayşe
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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