Publication: HMI-PRED: a web server for structural prediction of host-microbe interactions based on interface mimicry
dc.contributor.coauthor | Guven-Maiorov, Emine | |
dc.contributor.coauthor | Hakouz, Asma | |
dc.contributor.coauthor | Valjevac, Sukejna | |
dc.contributor.coauthor | Tsai, Chung-Jung | |
dc.contributor.coauthor | Nussinov, Ruth | |
dc.contributor.department | Department of Computer Engineering | |
dc.contributor.department | Department of Chemical and Biological Engineering | |
dc.contributor.kuauthor | Gürsoy, Attila | |
dc.contributor.kuauthor | Keskin, Özlem | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.date.accessioned | 2024-11-09T23:04:49Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Microbes, commensals, and pathogens, control the numerous functions in the host cells. They can alter host signaling and modulate immune surveillance by interacting with the host proteins. For shedding light on the contribution of microbes to health and disease, it is vital to discern how microbial proteins rewire host signaling and through which host proteins they do this. Host-Microbe Interaction PREDictor (HMI-PRED) is a user-friendly web server for structural prediction of protein-protein interactions (PPIs) between the host and a microbial species, including bacteria, viruses, fungi, and protozoa. HMI-PRED relies on "interface mimicry" through which the microbial proteins hijack host binding surfaces. Given the structure of a microbial protein of interest, HMI-PRED will return structural models of potential host-microbe interaction (HMI) complexes, the list of host endogenous and exogenous PPIs that can be disrupted, and tissue expression of the microbe-targeted host proteins. The server also allows users to upload homology models of microbial proteins. Broadly, it aims at large-scale, efficient identification of HMIs. The prediction results are stored in a repository for community access. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 11 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | National Cancer Institute, National Institutes of Health [HHSN261200800001E] | |
dc.description.sponsorship | Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research | |
dc.description.sponsorship | NATIONAL CANCER INSTITUTE [ZIABC010442, ZIABC010441, ZIABC010440] Funding Source: NIH RePORTER This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. | |
dc.description.volume | 432 | |
dc.identifier.doi | 10.1016/j.jmb.2020.01.025 | |
dc.identifier.eissn | 1089-8638 | |
dc.identifier.issn | 0022-2836 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85080101740 | |
dc.identifier.uri | https://doi.org/10.1016/j.jmb.2020.01.025 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/8698 | |
dc.identifier.wos | 536776300006 | |
dc.keywords | Host-microbe interaction | |
dc.keywords | Hmi | |
dc.keywords | Host-pathogen interaction | |
dc.keywords | Hpi | |
dc.keywords | Interface mimicry | |
dc.keywords | Computational prediction | |
dc.keywords | Modeling | |
dc.keywords | Protein-protein interaction | |
dc.keywords | Structure | |
dc.keywords | Protein-protein interactions | |
dc.keywords | Docking | |
dc.keywords | Similarities | |
dc.keywords | Repository | |
dc.keywords | Alignment | |
dc.keywords | Sequence | |
dc.language.iso | eng | |
dc.publisher | Academic Press Ltd- Elsevier Science Ltd | |
dc.relation.ispartof | Journal of Molecular Biology | |
dc.subject | Biochemistry | |
dc.subject | Molecular biology | |
dc.title | HMI-PRED: a web server for structural prediction of host-microbe interactions based on interface mimicry | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Keskin, Özlem | |
local.contributor.kuauthor | Gürsoy, Attila | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit2 | Department of Chemical and Biological Engineering | |
local.publication.orgunit2 | Department of Computer Engineering | |
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