Publication:
Primary tumour ulceration in cutaneous melanoma: its role on TNM stages

dc.contributor.coauthorTas, Faruk
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErtürk, Kayhan
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:12:23Z
dc.date.issued2021
dc.description.abstractBackground: Tumour ulceration has unfavourable prognostic factor in stage I-II melanoma. The aim of this study was to question whether tumour ulceration might predict relapse and survival in melanomas of all stages. Methods: A total of 911 melanoma patients were analysed. Results: The 5-year relapse-free survival rates were 50.0% for ulcerated melanomas and 75.8% for all non-ulcerated melanomas (P = 0.0001). Ulcerated melanomas had lower relapse-free survival rates than non-ulcerated melanomas in all T-stages (P = 0.0001). The relapse-free survival rates were statistically significant for T1 (P = 0.02), T3 (P = 0.01) and T4 (P = 0.004); however, T2 (P = 0.07). There were significant differences between ulcerated melanomas and non-ulcerated melanomas regarding relapse-free survival rates for both N0 (P = 0.0001) and N1 (P = 0.01) patients; poor relapse-free survival rates were found to be in association with ulcerated melanomas (P = 0.06 for N1, P = 0.04 for N2 and P = 0.8 for N3 disease). The 5- year overall survival rates were 55.3 and 81.5% for ulcerated melanomas and non-ulcerated melanomas, respectively (P = 0.0001). Ulcerated melanomas had lower overall survival rates than non-ulcerated melanomas in all Tstages; they were statistically significant for T1 (P = 0.01), T2 (P = 0.03) and T4 ( P = 0.006), but not for T3 (P = 0.3). Ulceration predicted poor survival in N0 patients; however, it was not found significant although its overall survival rate was lower in node-positive patients (P = 0.09), and ulceration was a significantly poor prognostic factor only for N3 patients (P = 0.03), but not for N1 (P = 0.9) and N2 patients (P = 0.2). Furthermore, non-metastatic patients with ulcerated melanomas survived significantly less (P = 0.0001), but there were no differences in survivals between ulcerated melanoma and non-ulcerated melanoma metastatic melanoma patients (P = 0.1). Conclusion: Primary tumour ulceration has been considered as a poor prognostic factor in local melanomas, but it might also have a potential for predicting survival in loco-regional and advanced melanomas.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume51
dc.identifier.doi10.1093/jjco/hyaa191
dc.identifier.eissn1465-3621
dc.identifier.issn0368-2811
dc.identifier.scopus2-s2.0-85102089624
dc.identifier.urihttps://doi.org/10.1093/jjco/hyaa191
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9802
dc.identifier.wos648740500005
dc.keywordsMelanoma
dc.keywordsUlceration
dc.keywordsPrognostic factor
dc.keywordsTNM stages
dc.keywordsAmerican Joint Committee
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofJapanese Journal of Clinical Oncology
dc.subjectOncology
dc.titlePrimary tumour ulceration in cutaneous melanoma: its role on TNM stages
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorErtürk, Kayhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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