Publication: Primary tumour ulceration in cutaneous melanoma: its role on TNM stages
dc.contributor.coauthor | Tas, Faruk | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ertürk, Kayhan | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:12:23Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: Tumour ulceration has unfavourable prognostic factor in stage I-II melanoma. The aim of this study was to question whether tumour ulceration might predict relapse and survival in melanomas of all stages. Methods: A total of 911 melanoma patients were analysed. Results: The 5-year relapse-free survival rates were 50.0% for ulcerated melanomas and 75.8% for all non-ulcerated melanomas (P = 0.0001). Ulcerated melanomas had lower relapse-free survival rates than non-ulcerated melanomas in all T-stages (P = 0.0001). The relapse-free survival rates were statistically significant for T1 (P = 0.02), T3 (P = 0.01) and T4 (P = 0.004); however, T2 (P = 0.07). There were significant differences between ulcerated melanomas and non-ulcerated melanomas regarding relapse-free survival rates for both N0 (P = 0.0001) and N1 (P = 0.01) patients; poor relapse-free survival rates were found to be in association with ulcerated melanomas (P = 0.06 for N1, P = 0.04 for N2 and P = 0.8 for N3 disease). The 5- year overall survival rates were 55.3 and 81.5% for ulcerated melanomas and non-ulcerated melanomas, respectively (P = 0.0001). Ulcerated melanomas had lower overall survival rates than non-ulcerated melanomas in all Tstages; they were statistically significant for T1 (P = 0.01), T2 (P = 0.03) and T4 ( P = 0.006), but not for T3 (P = 0.3). Ulceration predicted poor survival in N0 patients; however, it was not found significant although its overall survival rate was lower in node-positive patients (P = 0.09), and ulceration was a significantly poor prognostic factor only for N3 patients (P = 0.03), but not for N1 (P = 0.9) and N2 patients (P = 0.2). Furthermore, non-metastatic patients with ulcerated melanomas survived significantly less (P = 0.0001), but there were no differences in survivals between ulcerated melanoma and non-ulcerated melanoma metastatic melanoma patients (P = 0.1). Conclusion: Primary tumour ulceration has been considered as a poor prognostic factor in local melanomas, but it might also have a potential for predicting survival in loco-regional and advanced melanomas. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 2 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 51 | |
dc.identifier.doi | 10.1093/jjco/hyaa191 | |
dc.identifier.eissn | 1465-3621 | |
dc.identifier.issn | 0368-2811 | |
dc.identifier.scopus | 2-s2.0-85102089624 | |
dc.identifier.uri | https://doi.org/10.1093/jjco/hyaa191 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/9802 | |
dc.identifier.wos | 648740500005 | |
dc.keywords | Melanoma | |
dc.keywords | Ulceration | |
dc.keywords | Prognostic factor | |
dc.keywords | TNM stages | |
dc.keywords | American Joint Committee | |
dc.language.iso | eng | |
dc.publisher | Oxford Univ Press | |
dc.relation.ispartof | Japanese Journal of Clinical Oncology | |
dc.subject | Oncology | |
dc.title | Primary tumour ulceration in cutaneous melanoma: its role on TNM stages | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ertürk, Kayhan | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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