Publication: Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial
dc.contributor.coauthor | Meersch, Melanie | |
dc.contributor.coauthor | Weiss, Raphael | |
dc.contributor.coauthor | Strauß, Christian | |
dc.contributor.coauthor | Albert, Felix | |
dc.contributor.coauthor | Booke, Hendrik | |
dc.contributor.coauthor | Forni, Lui | |
dc.contributor.coauthor | Pittet, Jean-Francois | |
dc.contributor.coauthor | Kellum, John A. | |
dc.contributor.coauthor | Rosner, Mitchell | |
dc.contributor.coauthor | Mehta, Ravindra | |
dc.contributor.coauthor | Bellomo, Rinaldo | |
dc.contributor.coauthor | Rosenberger, Peter | |
dc.contributor.coauthor | Zarbock, Alexander | |
dc.contributor.coauthor | Makhloufi, Hichem | |
dc.contributor.coauthor | Sakhraoui, Rachida | |
dc.contributor.coauthor | Ouyahia, Amel | |
dc.contributor.coauthor | Rais, Mounira | |
dc.contributor.coauthor | Kouicem, Aya Tinhinane | |
dc.contributor.coauthor | Derwish, Khawla | |
dc.contributor.coauthor | Abdoun, Meriem | |
dc.contributor.coauthor | Ouahab, Ilhem | |
dc.contributor.coauthor | Bouaoud, Souad | |
dc.contributor.coauthor | Tidjane, Anisse | |
dc.contributor.coauthor | Pérez Rivera, Carlos Jose | |
dc.contributor.coauthor | García, Juan Pablo | |
dc.contributor.coauthor | Peng, Ke | |
dc.contributor.coauthor | Ji, Fu-Hai | |
dc.contributor.coauthor | Ma, Zheng-Min | |
dc.contributor.coauthor | Elbahnasawy, Mohamed Gamal | |
dc.contributor.coauthor | Elsalhawy, Shady | |
dc.contributor.coauthor | Nafea, Ahmed Mahmoud | |
dc.contributor.coauthor | Osman, Nermin A. | |
dc.contributor.coauthor | Emara, Moataz Maher | |
dc.contributor.coauthor | Bonna, Mohamed Mamdouh | |
dc.contributor.coauthor | Abdehaleem, Ibrahim Abdelmonaem | |
dc.contributor.coauthor | Abbas, Ahmed Mohamed | |
dc.contributor.coauthor | Abbas, Mostafa Samy | |
dc.contributor.coauthor | Esmaeil, Hany Mostafa | |
dc.contributor.coauthor | Joannes-Boyau, Oliver | |
dc.contributor.coauthor | Legros, Vincent | |
dc.contributor.coauthor | Floch, Thierry | |
dc.contributor.coauthor | Muccio, Salvatore | |
dc.contributor.coauthor | Menage-Innocenti, Lison | |
dc.contributor.coauthor | Brochet, Benjamin | |
dc.contributor.coauthor | Leclercq-Rouget, Marion | |
dc.contributor.coauthor | Geneve, Claire | |
dc.contributor.coauthor | Mocarquer, Bernardita Valenzuela | |
dc.contributor.coauthor | Aveline, Christophe | |
dc.contributor.coauthor | Vautier, Pierre | |
dc.contributor.coauthor | Nadaud, Julien | |
dc.contributor.coauthor | Rimmelé, Thomas | |
dc.contributor.coauthor | Cerro, Valérie | |
dc.contributor.coauthor | Suria, Stéphanie | |
dc.contributor.coauthor | Elmawieh, Jamie | |
dc.contributor.coauthor | El-Jawiche, Rita | |
dc.contributor.coauthor | Cirenei, Cédric | |
dc.contributor.coauthor | Lebuffe, Gilles | |
dc.contributor.coauthor | Ponsonnard, Sébastien | |
dc.contributor.coauthor | Egreteau, Pierre-Yves | |
dc.contributor.coauthor | Ichai, Carole | |
dc.contributor.coauthor | Jean-Michel, Vanessa | |
dc.contributor.coauthor | Léger, Maxime | |
dc.contributor.coauthor | Lasocki, Sigismond | |
dc.contributor.coauthor | Masson, Charline | |
dc.contributor.coauthor | Rineau, Emmanuel | |
dc.contributor.coauthor | Cassisa, Viviane | |
dc.contributor.coauthor | Verrier, Pierre | |
dc.contributor.coauthor | Atchade, Enora | |
dc.contributor.coauthor | Rochon, Charles-Edouard | |
dc.contributor.coauthor | Quentin, Vidal | |
dc.contributor.coauthor | Queixalos, Nina | |
dc.contributor.coauthor | Braun, Thierry | |
dc.contributor.coauthor | Grand, Hubert | |
dc.contributor.coauthor | Mayeur, Nicolas | |
dc.contributor.coauthor | Pasquie, Marie | |
dc.contributor.coauthor | Garçon, Pierre | |
dc.contributor.coauthor | Bruckert, Vincent | |
dc.contributor.coauthor | Pradel, Gaël | |
dc.contributor.coauthor | Ramorasata, Andersen | |
dc.contributor.coauthor | Ravry, Céline | |
dc.contributor.coauthor | Mottard, Nicolas | |
dc.contributor.coauthor | von Groote, Thilo | |
dc.contributor.coauthor | Dörr, Christian | |
dc.contributor.coauthor | Küllmar, Mira | |
dc.contributor.coauthor | Massoth, Christina | |
dc.contributor.coauthor | Motekallemi, Arash | |
dc.contributor.coauthor | Saadat-Gilani, Khaschayar | |
dc.contributor.coauthor | Kerschke, Laura | |
dc.contributor.coauthor | Storck, Michael | |
dc.contributor.coauthor | Varghese, Julian | |
dc.contributor.coauthor | Wempe, Carola | |
dc.contributor.coauthor | Grüßer, Linda | |
dc.contributor.coauthor | Kowark, Ana | |
dc.contributor.coauthor | Brandenburger, Timo | |
dc.contributor.coauthor | Hohn, Andreas | |
dc.contributor.coauthor | Häberle, Helene | |
dc.contributor.coauthor | Hofmann, Pascal | |
dc.contributor.coauthor | Kuhle, Jonathan | |
dc.contributor.coauthor | Calov, Stefanie | |
dc.contributor.coauthor | Bernard, Alice Marie | |
dc.contributor.coauthor | Mirakaj, Valbona | |
dc.contributor.coauthor | Weber, Kathrin | |
dc.contributor.coauthor | Pfister, Kathrin | |
dc.contributor.coauthor | Stetz, Lena | |
dc.contributor.coauthor | Müller, Sarah Dorothea | |
dc.contributor.coauthor | Klaus, Stephan | |
dc.contributor.coauthor | Sadlo, Marco | |
dc.contributor.coauthor | Sengelhoff, Christian | |
dc.contributor.coauthor | Stenger, Carina-Kristin | |
dc.contributor.coauthor | Göbel, Ulrich | |
dc.contributor.coauthor | Heringlake, Matthias | |
dc.contributor.coauthor | Arnaoutoglou, Eleni | |
dc.contributor.coauthor | Stratigopoulou, Panagiota | |
dc.contributor.coauthor | Danai, Pantazi | |
dc.contributor.coauthor | Dimakopoulou, Antonia | |
dc.contributor.coauthor | Menis, Apostolos-Alkiviadis | |
dc.contributor.coauthor | Ioannidis, Orestis | |
dc.contributor.coauthor | Jalaawiy, Humam | |
dc.contributor.coauthor | Anwar, Aeshah | |
dc.contributor.coauthor | Hashim, Hashim Talib | |
dc.contributor.coauthor | Rasheed Aldawoody, Hogir Imad | |
dc.contributor.coauthor | Cortegiani, Andrea | |
dc.contributor.coauthor | Ippolito, Mariachiara | |
dc.contributor.coauthor | Marino, Claudia | |
dc.contributor.coauthor | Presti, Gabriele | |
dc.contributor.coauthor | Fricano, Dario Calogero | |
dc.contributor.coauthor | De Rosa, Silvia | |
dc.contributor.coauthor | Bianchin, Andrea | |
dc.contributor.coauthor | Paternoster, Gianluca | |
dc.contributor.coauthor | Fasciano, Umberto | |
dc.contributor.coauthor | Cutuli, Salvatore Lucio | |
dc.contributor.coauthor | Savino, Spadaro | |
dc.contributor.coauthor | Enrico, Bussolati | |
dc.contributor.coauthor | Marco, Palmieri | |
dc.contributor.coauthor | Alberto, Volta Carlo | |
dc.contributor.coauthor | Tripodi, Vincenzo Francesco | |
dc.contributor.coauthor | Fiume, Diego | |
dc.contributor.coauthor | Iuorio, Angela | |
dc.contributor.coauthor | Santorsola, Clemente | |
dc.contributor.coauthor | Abu-Hussein, Bilal | |
dc.contributor.coauthor | Hasanein, Khaled | |
dc.contributor.coauthor | Shin, Seokyung | |
dc.contributor.coauthor | Baek, Jongyoon | |
dc.contributor.coauthor | Kim, Sehui | |
dc.contributor.coauthor | Elhadi, Muhammed | |
dc.contributor.coauthor | Aldressi, Wafa | |
dc.contributor.coauthor | Abuzeid, Issa A. | |
dc.contributor.coauthor | Albaraesi, Mohammed N. | |
dc.contributor.coauthor | Moftah, Mohamed Aziz | |
dc.contributor.coauthor | Aldressi, Sarah | |
dc.contributor.coauthor | Khalel, Wegdan | |
dc.contributor.coauthor | Abdulwahed, Eman | |
dc.contributor.coauthor | Ali Alshareea, Entisar Ahmed | |
dc.contributor.coauthor | Abujrad Reem Ghmagh, Akram Abdulhamid Ashur | |
dc.contributor.coauthor | Biala, Marwa Isa | |
dc.contributor.coauthor | Benjouira, Rayet Al Islam | |
dc.contributor.coauthor | Aliwa, Mohamed | |
dc.contributor.coauthor | Msherghi, Ahmed | |
dc.contributor.coauthor | Tuwaib, Ahmed | |
dc.contributor.coauthor | Mustafa, Tahani | |
dc.contributor.coauthor | Zriba, Haifa | |
dc.contributor.coauthor | Agilla, Hamza Mahmoud | |
dc.contributor.coauthor | Sadek Ben Hamida, Bahaeddin Taher | |
dc.contributor.coauthor | Mohamed Otman, Rema Hassan | |
dc.contributor.coauthor | Mijovska, Maja Mojsova | |
dc.contributor.coauthor | Podesta, Anne Marie Camilleri | |
dc.contributor.coauthor | Gasca López, Gilberto Adrián | |
dc.contributor.coauthor | Amro, Sarah | |
dc.contributor.coauthor | de Freitas Regufe, Rita | |
dc.contributor.coauthor | Grigoryev, Evgeny | |
dc.contributor.coauthor | Ivkin, Artem | |
dc.contributor.coauthor | Balakhnin, Dmitriy | |
dc.contributor.coauthor | Shukevich, Dmitriy | |
dc.contributor.coauthor | Yaroustovsky, Michael | |
dc.contributor.coauthor | Barmou, Abdulnaser | |
dc.contributor.coauthor | Kaserer, Alexander | |
dc.contributor.coauthor | Castellucci, Clara | |
dc.contributor.coauthor | Akbas, Samira | |
dc.contributor.coauthor | Petrun, Andreja Möller | |
dc.contributor.coauthor | Gregorcic, Irena | |
dc.contributor.coauthor | Sok, Vesna | |
dc.contributor.coauthor | Links, Andre | |
dc.contributor.coauthor | Barreto, Elizabeth Bárcena | |
dc.contributor.coauthor | Melchor, Javier Ripollés | |
dc.contributor.coauthor | Becerra-Bolaños, Ángel | |
dc.contributor.coauthor | Rodríguez-Pérez, Aurelio | |
dc.contributor.coauthor | Estévez, Javier Mata | |
dc.contributor.coauthor | Matas, Juan Mulet | |
dc.contributor.coauthor | Palao, Sara Pérez | |
dc.contributor.coauthor | Álvarez, Mercedes García | |
dc.contributor.coauthor | Albadalejo, Albert Bainac | |
dc.contributor.coauthor | González, Astrid Batalla | |
dc.contributor.coauthor | Caro, Ana María Gómez | |
dc.contributor.coauthor | Blanco, Ignacio Hinojal | |
dc.contributor.coauthor | Fernandez, Diego Toral | |
dc.contributor.coauthor | Perez, Gracia Herranz | |
dc.contributor.coauthor | Ejea, Margarita Logroño | |
dc.contributor.coauthor | de la Rosa Ruiz, Noelia | |
dc.contributor.coauthor | Abasolo, María Gastaca | |
dc.contributor.coauthor | Ferreira, Lourdes | |
dc.contributor.coauthor | Lobato, Félix | |
dc.contributor.coauthor | Sevilla, Marta Aguado | |
dc.contributor.coauthor | Erazo, Andres | |
dc.contributor.coauthor | Paulis, Berta Castellano | |
dc.contributor.coauthor | de la Calle Gil, Isabel | |
dc.contributor.coauthor | Adamove, Peter | |
dc.contributor.coauthor | Blasco, Francho Miguel Blasco | |
dc.contributor.coauthor | García-Sánchez, Jose Ignacio | |
dc.contributor.coauthor | Zamorano, Sara García | |
dc.contributor.coauthor | Herreros, Natalia Gijón | |
dc.contributor.coauthor | Callejas, Raquel | |
dc.contributor.coauthor | Gómez, Mercedes Estaire | |
dc.contributor.coauthor | Candela-Toha, Angel M. | |
dc.contributor.coauthor | Claros-Llamas, Elisabeth | |
dc.contributor.coauthor | Cobeta-Orduña, Pilar | |
dc.contributor.coauthor | Crespo-Aliseda, Pascual | |
dc.contributor.coauthor | Dorado-Díaz, Trinidad | |
dc.contributor.coauthor | Gómez-Rojo, María | |
dc.contributor.coauthor | Mané-Ruiz, M. Nuria | |
dc.contributor.coauthor | González, M. Carmen Martín- | |
dc.contributor.coauthor | Martínez-Pérez, Adolfo | |
dc.contributor.coauthor | Tiscar, Carlos | |
dc.contributor.coauthor | Menéndez, Patricia Galán | |
dc.contributor.coauthor | Calvo, Verónica Estepa | |
dc.contributor.coauthor | Espí, Laura Llinares | |
dc.contributor.coauthor | Aldeán, Yuri Santiago Loaiza | |
dc.contributor.coauthor | Ariza, Víctor Morales | |
dc.contributor.coauthor | Vila, Laura Villarino | |
dc.contributor.coauthor | García-Miguel, Francisco Javier | |
dc.contributor.coauthor | Suliman, Elfayadh S. M. | |
dc.contributor.coauthor | Ibrahim, Ahmed Mohamed | |
dc.contributor.coauthor | Fadlalmola, Hammad Ali. | |
dc.contributor.coauthor | Swed, Sarya | |
dc.contributor.coauthor | Wu, Vin-Cent | |
dc.contributor.coauthor | Orhan-Sungur, Mukadder | |
dc.contributor.coauthor | Altun, Demet | |
dc.contributor.coauthor | Canbolat, Nur | |
dc.contributor.coauthor | Dinçer, Müşerref Beril | |
dc.contributor.coauthor | Yildirim, Serap Aktas | |
dc.contributor.coauthor | Iyigun, Muzeyyen | |
dc.contributor.coauthor | Yapıcı, Davud | |
dc.contributor.coauthor | Özdemir, Levent | |
dc.contributor.coauthor | Sagün, Aslınur | |
dc.contributor.coauthor | Boztug, Neval | |
dc.contributor.coauthor | Gündüz, Emel | |
dc.contributor.coauthor | Lafli-Tunay, Demet | |
dc.contributor.coauthor | Karakaya, Deniz | |
dc.contributor.coauthor | Dost, Burhan | |
dc.contributor.coauthor | Komurcu, Ozgur | |
dc.contributor.coauthor | Dilmen, Ozlem Korkmaz | |
dc.contributor.coauthor | Akcil, Eren Fatma | |
dc.contributor.coauthor | Tunali, Yusuf | |
dc.contributor.coauthor | Ok, Gulay | |
dc.contributor.coauthor | Tok-Alsina, Eda | |
dc.contributor.coauthor | Polat, Cengiz | |
dc.contributor.coauthor | Kızılcık, Nurcan | |
dc.contributor.coauthor | Şen, Öznur | |
dc.contributor.coauthor | Darçın, Kamil | |
dc.contributor.coauthor | Uğur, Semra | |
dc.contributor.coauthor | Gürkan, Yavuz | |
dc.contributor.coauthor | Saracoglu, Kemal Tolga | |
dc.contributor.coauthor | Yıldız-Koyuncu, Özge | |
dc.contributor.coauthor | Demir, Z. Aslı | |
dc.contributor.coauthor | Postacı, N. Aysun | |
dc.contributor.coauthor | Özgök, Ayşegül | |
dc.contributor.coauthor | Karadeniz, Ümit | |
dc.contributor.coauthor | Özay, Hülya Yiğit | |
dc.contributor.coauthor | Balcı, Eda | |
dc.contributor.coauthor | Salman, Nevriye | |
dc.contributor.coauthor | Girgin, Behiç | |
dc.contributor.coauthor | Sagir, Ozlem | |
dc.contributor.coauthor | Demir, Hafize Fisun | |
dc.contributor.coauthor | Ugun, Fatih | |
dc.contributor.coauthor | Toprak, Hüseyin İlksen | |
dc.contributor.coauthor | Özcan, Mustafa Soner | |
dc.contributor.coauthor | Alkaya-Solmaz, Filiz | |
dc.contributor.coauthor | Yilmaz, Mehmet | |
dc.contributor.coauthor | Karaca, Umran | |
dc.contributor.coauthor | Şahin, Sevtap Hekimoglu | |
dc.contributor.coauthor | Erkoç, Süheyla Karadağ | |
dc.contributor.coauthor | Alkış, Neslihan | |
dc.contributor.coauthor | Baytaş, Volkan | |
dc.contributor.coauthor | Erturk, Engin | |
dc.contributor.coauthor | Saylan, Sedat | |
dc.contributor.coauthor | Akdogan, Ali | |
dc.contributor.coauthor | Yeşil, Beyza Büyükgebiz | |
dc.contributor.coauthor | Boran, Omer Faruk | |
dc.contributor.coauthor | Orak, Yavuz | |
dc.contributor.coauthor | Çalişir, Feyza | |
dc.contributor.coauthor | Büyükçoban, Sibel | |
dc.contributor.coauthor | Kuvaki, Bahar | |
dc.contributor.coauthor | Cansabuncu, Seda | |
dc.contributor.coauthor | Akesen, Selcan | |
dc.contributor.coauthor | Gören, Suna | |
dc.contributor.coauthor | Yeniocak, Tugce | |
dc.contributor.coauthor | Orman, Osman | |
dc.contributor.coauthor | Karka, Özlem Ersoy | |
dc.contributor.coauthor | Sahin, Tulay | |
dc.contributor.coauthor | Momot, Natalia | |
dc.contributor.coauthor | Panchenko, Anna | |
dc.contributor.coauthor | Pittet, Jean-Francois | |
dc.contributor.coauthor | Rutledge, Kristen | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Gürkan, Yavuz | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-01-19T10:31:20Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Purpose: Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. Methods: We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. Results: We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21–3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. Conclusion: One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. © The Author(s) 2024. | |
dc.description.indexedby | Scopus | |
dc.description.openaccess | All Open Access; Hybrid Gold Open Access | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Open Access funding enabled and organized by Projekt DEAL. The study was supported by the German Research Foundation (KFO342-1, ZA428/18-1, and ZA428/21-1 to AZ and ME5413/1-1 and ME5413/1-2 to MM) and by an unrestricted research grant from Baxter (to AZ). | |
dc.identifier.doi | 10.1007/s00134-023-07314-2 | |
dc.identifier.issn | 3424642 | |
dc.identifier.quartile | N/A | |
dc.identifier.uri | https://doi.org/10.1007/s00134-023-07314-2 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/26222 | |
dc.keywords | Acute kidney disease | |
dc.keywords | Acute kidney injury | |
dc.keywords | Chronic kidney disease | |
dc.keywords | Postoperative | |
dc.keywords | Surgery | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media Deutschland Gmbh | |
dc.relation.grantno | Baxter International; Deutsche Forschungsgemeinschaft, DFG, (KFO342-1, ME5413/1-1, ME5413/1-2, ZA428/18-1, ZA428/21-1); Deutsche Forschungsgemeinschaft, DFG | |
dc.relation.ispartof | Intensive Care Medicine | |
dc.title | Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Gürkan, Yavuz | |
local.contributor.kuauthor | Darçın Kamil | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |
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