Publication:
Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial

dc.contributor.coauthorMeersch, Melanie
dc.contributor.coauthorWeiss, Raphael
dc.contributor.coauthorStrauß, Christian
dc.contributor.coauthorAlbert, Felix
dc.contributor.coauthorBooke, Hendrik
dc.contributor.coauthorForni, Lui
dc.contributor.coauthorPittet, Jean-Francois
dc.contributor.coauthorKellum, John A.
dc.contributor.coauthorRosner, Mitchell
dc.contributor.coauthorMehta, Ravindra
dc.contributor.coauthorBellomo, Rinaldo
dc.contributor.coauthorRosenberger, Peter
dc.contributor.coauthorZarbock, Alexander
dc.contributor.coauthorMakhloufi, Hichem
dc.contributor.coauthorSakhraoui, Rachida
dc.contributor.coauthorOuyahia, Amel
dc.contributor.coauthorRais, Mounira
dc.contributor.coauthorKouicem, Aya Tinhinane
dc.contributor.coauthorDerwish, Khawla
dc.contributor.coauthorAbdoun, Meriem
dc.contributor.coauthorOuahab, Ilhem
dc.contributor.coauthorBouaoud, Souad
dc.contributor.coauthorTidjane, Anisse
dc.contributor.coauthorPérez Rivera, Carlos Jose
dc.contributor.coauthorGarcía, Juan Pablo
dc.contributor.coauthorPeng, Ke
dc.contributor.coauthorJi, Fu-Hai
dc.contributor.coauthorMa, Zheng-Min
dc.contributor.coauthorElbahnasawy, Mohamed Gamal
dc.contributor.coauthorElsalhawy, Shady
dc.contributor.coauthorNafea, Ahmed Mahmoud
dc.contributor.coauthorOsman, Nermin A.
dc.contributor.coauthorEmara, Moataz Maher
dc.contributor.coauthorBonna, Mohamed Mamdouh
dc.contributor.coauthorAbdehaleem, Ibrahim Abdelmonaem
dc.contributor.coauthorAbbas, Ahmed Mohamed
dc.contributor.coauthorAbbas, Mostafa Samy
dc.contributor.coauthorEsmaeil, Hany Mostafa
dc.contributor.coauthorJoannes-Boyau, Oliver
dc.contributor.coauthorLegros, Vincent
dc.contributor.coauthorFloch, Thierry
dc.contributor.coauthorMuccio, Salvatore
dc.contributor.coauthorMenage-Innocenti, Lison
dc.contributor.coauthorBrochet, Benjamin
dc.contributor.coauthorLeclercq-Rouget, Marion
dc.contributor.coauthorGeneve, Claire
dc.contributor.coauthorMocarquer, Bernardita Valenzuela
dc.contributor.coauthorAveline, Christophe
dc.contributor.coauthorVautier, Pierre
dc.contributor.coauthorNadaud, Julien
dc.contributor.coauthorRimmelé, Thomas
dc.contributor.coauthorCerro, Valérie
dc.contributor.coauthorSuria, Stéphanie
dc.contributor.coauthorElmawieh, Jamie
dc.contributor.coauthorEl-Jawiche, Rita
dc.contributor.coauthorCirenei, Cédric
dc.contributor.coauthorLebuffe, Gilles
dc.contributor.coauthorPonsonnard, Sébastien
dc.contributor.coauthorEgreteau, Pierre-Yves
dc.contributor.coauthorIchai, Carole
dc.contributor.coauthorJean-Michel, Vanessa
dc.contributor.coauthorLéger, Maxime
dc.contributor.coauthorLasocki, Sigismond
dc.contributor.coauthorMasson, Charline
dc.contributor.coauthorRineau, Emmanuel
dc.contributor.coauthorCassisa, Viviane
dc.contributor.coauthorVerrier, Pierre
dc.contributor.coauthorAtchade, Enora
dc.contributor.coauthorRochon, Charles-Edouard
dc.contributor.coauthorQuentin, Vidal
dc.contributor.coauthorQueixalos, Nina
dc.contributor.coauthorBraun, Thierry
dc.contributor.coauthorGrand, Hubert
dc.contributor.coauthorMayeur, Nicolas
dc.contributor.coauthorPasquie, Marie
dc.contributor.coauthorGarçon, Pierre
dc.contributor.coauthorBruckert, Vincent
dc.contributor.coauthorPradel, Gaël
dc.contributor.coauthorRamorasata, Andersen
dc.contributor.coauthorRavry, Céline
dc.contributor.coauthorMottard, Nicolas
dc.contributor.coauthorvon Groote, Thilo
dc.contributor.coauthorDörr, Christian
dc.contributor.coauthorKüllmar, Mira
dc.contributor.coauthorMassoth, Christina
dc.contributor.coauthorMotekallemi, Arash
dc.contributor.coauthorSaadat-Gilani, Khaschayar
dc.contributor.coauthorKerschke, Laura
dc.contributor.coauthorStorck, Michael
dc.contributor.coauthorVarghese, Julian
dc.contributor.coauthorWempe, Carola
dc.contributor.coauthorGrüßer, Linda
dc.contributor.coauthorKowark, Ana
dc.contributor.coauthorBrandenburger, Timo
dc.contributor.coauthorHohn, Andreas
dc.contributor.coauthorHäberle, Helene
dc.contributor.coauthorHofmann, Pascal
dc.contributor.coauthorKuhle, Jonathan
dc.contributor.coauthorCalov, Stefanie
dc.contributor.coauthorBernard, Alice Marie
dc.contributor.coauthorMirakaj, Valbona
dc.contributor.coauthorWeber, Kathrin
dc.contributor.coauthorPfister, Kathrin
dc.contributor.coauthorStetz, Lena
dc.contributor.coauthorMüller, Sarah Dorothea
dc.contributor.coauthorKlaus, Stephan
dc.contributor.coauthorSadlo, Marco
dc.contributor.coauthorSengelhoff, Christian
dc.contributor.coauthorStenger, Carina-Kristin
dc.contributor.coauthorGöbel, Ulrich
dc.contributor.coauthorHeringlake, Matthias
dc.contributor.coauthorArnaoutoglou, Eleni
dc.contributor.coauthorStratigopoulou, Panagiota
dc.contributor.coauthorDanai, Pantazi
dc.contributor.coauthorDimakopoulou, Antonia
dc.contributor.coauthorMenis, Apostolos-Alkiviadis
dc.contributor.coauthorIoannidis, Orestis
dc.contributor.coauthorJalaawiy, Humam
dc.contributor.coauthorAnwar, Aeshah
dc.contributor.coauthorHashim, Hashim Talib
dc.contributor.coauthorRasheed Aldawoody, Hogir Imad
dc.contributor.coauthorCortegiani, Andrea
dc.contributor.coauthorIppolito, Mariachiara
dc.contributor.coauthorMarino, Claudia
dc.contributor.coauthorPresti, Gabriele
dc.contributor.coauthorFricano, Dario Calogero
dc.contributor.coauthorDe Rosa, Silvia
dc.contributor.coauthorBianchin, Andrea
dc.contributor.coauthorPaternoster, Gianluca
dc.contributor.coauthorFasciano, Umberto
dc.contributor.coauthorCutuli, Salvatore Lucio
dc.contributor.coauthorSavino, Spadaro
dc.contributor.coauthorEnrico, Bussolati
dc.contributor.coauthorMarco, Palmieri
dc.contributor.coauthorAlberto, Volta Carlo
dc.contributor.coauthorTripodi, Vincenzo Francesco
dc.contributor.coauthorFiume, Diego
dc.contributor.coauthorIuorio, Angela
dc.contributor.coauthorSantorsola, Clemente
dc.contributor.coauthorAbu-Hussein, Bilal
dc.contributor.coauthorHasanein, Khaled
dc.contributor.coauthorShin, Seokyung
dc.contributor.coauthorBaek, Jongyoon
dc.contributor.coauthorKim, Sehui
dc.contributor.coauthorElhadi, Muhammed
dc.contributor.coauthorAldressi, Wafa
dc.contributor.coauthorAbuzeid, Issa A.
dc.contributor.coauthorAlbaraesi, Mohammed N.
dc.contributor.coauthorMoftah, Mohamed Aziz
dc.contributor.coauthorAldressi, Sarah
dc.contributor.coauthorKhalel, Wegdan
dc.contributor.coauthorAbdulwahed, Eman
dc.contributor.coauthorAli Alshareea, Entisar Ahmed
dc.contributor.coauthorAbujrad Reem Ghmagh, Akram Abdulhamid Ashur
dc.contributor.coauthorBiala, Marwa Isa
dc.contributor.coauthorBenjouira, Rayet Al Islam
dc.contributor.coauthorAliwa, Mohamed
dc.contributor.coauthorMsherghi, Ahmed
dc.contributor.coauthorTuwaib, Ahmed
dc.contributor.coauthorMustafa, Tahani
dc.contributor.coauthorZriba, Haifa
dc.contributor.coauthorAgilla, Hamza Mahmoud
dc.contributor.coauthorSadek Ben Hamida, Bahaeddin Taher
dc.contributor.coauthorMohamed Otman, Rema Hassan
dc.contributor.coauthorMijovska, Maja Mojsova
dc.contributor.coauthorPodesta, Anne Marie Camilleri
dc.contributor.coauthorGasca López, Gilberto Adrián
dc.contributor.coauthorAmro, Sarah
dc.contributor.coauthorde Freitas Regufe, Rita
dc.contributor.coauthorGrigoryev, Evgeny
dc.contributor.coauthorIvkin, Artem
dc.contributor.coauthorBalakhnin, Dmitriy
dc.contributor.coauthorShukevich, Dmitriy
dc.contributor.coauthorYaroustovsky, Michael
dc.contributor.coauthorBarmou, Abdulnaser
dc.contributor.coauthorKaserer, Alexander
dc.contributor.coauthorCastellucci, Clara
dc.contributor.coauthorAkbas, Samira
dc.contributor.coauthorPetrun, Andreja Möller
dc.contributor.coauthorGregorcic, Irena
dc.contributor.coauthorSok, Vesna
dc.contributor.coauthorLinks, Andre
dc.contributor.coauthorBarreto, Elizabeth Bárcena
dc.contributor.coauthorMelchor, Javier Ripollés
dc.contributor.coauthorBecerra-Bolaños, Ángel
dc.contributor.coauthorRodríguez-Pérez, Aurelio
dc.contributor.coauthorEstévez, Javier Mata
dc.contributor.coauthorMatas, Juan Mulet
dc.contributor.coauthorPalao, Sara Pérez
dc.contributor.coauthorÁlvarez, Mercedes García
dc.contributor.coauthorAlbadalejo, Albert Bainac
dc.contributor.coauthorGonzález, Astrid Batalla
dc.contributor.coauthorCaro, Ana María Gómez
dc.contributor.coauthorBlanco, Ignacio Hinojal
dc.contributor.coauthorFernandez, Diego Toral
dc.contributor.coauthorPerez, Gracia Herranz
dc.contributor.coauthorEjea, Margarita Logroño
dc.contributor.coauthorde la Rosa Ruiz, Noelia
dc.contributor.coauthorAbasolo, María Gastaca
dc.contributor.coauthorFerreira, Lourdes
dc.contributor.coauthorLobato, Félix
dc.contributor.coauthorSevilla, Marta Aguado
dc.contributor.coauthorErazo, Andres
dc.contributor.coauthorPaulis, Berta Castellano
dc.contributor.coauthorde la Calle Gil, Isabel
dc.contributor.coauthorAdamove, Peter
dc.contributor.coauthorBlasco, Francho Miguel Blasco
dc.contributor.coauthorGarcía-Sánchez, Jose Ignacio
dc.contributor.coauthorZamorano, Sara García
dc.contributor.coauthorHerreros, Natalia Gijón
dc.contributor.coauthorCallejas, Raquel
dc.contributor.coauthorGómez, Mercedes Estaire
dc.contributor.coauthorCandela-Toha, Angel M.
dc.contributor.coauthorClaros-Llamas, Elisabeth
dc.contributor.coauthorCobeta-Orduña, Pilar
dc.contributor.coauthorCrespo-Aliseda, Pascual
dc.contributor.coauthorDorado-Díaz, Trinidad
dc.contributor.coauthorGómez-Rojo, María
dc.contributor.coauthorMané-Ruiz, M. Nuria
dc.contributor.coauthorGonzález, M. Carmen Martín-
dc.contributor.coauthorMartínez-Pérez, Adolfo
dc.contributor.coauthorTiscar, Carlos
dc.contributor.coauthorMenéndez, Patricia Galán
dc.contributor.coauthorCalvo, Verónica Estepa
dc.contributor.coauthorEspí, Laura Llinares
dc.contributor.coauthorAldeán, Yuri Santiago Loaiza
dc.contributor.coauthorAriza, Víctor Morales
dc.contributor.coauthorVila, Laura Villarino
dc.contributor.coauthorGarcía-Miguel, Francisco Javier
dc.contributor.coauthorSuliman, Elfayadh S. M.
dc.contributor.coauthorIbrahim, Ahmed Mohamed
dc.contributor.coauthorFadlalmola, Hammad Ali.
dc.contributor.coauthorSwed, Sarya
dc.contributor.coauthorWu, Vin-Cent
dc.contributor.coauthorOrhan-Sungur, Mukadder
dc.contributor.coauthorAltun, Demet
dc.contributor.coauthorCanbolat, Nur
dc.contributor.coauthorDinçer, Müşerref Beril
dc.contributor.coauthorYildirim, Serap Aktas
dc.contributor.coauthorIyigun, Muzeyyen
dc.contributor.coauthorYapıcı, Davud
dc.contributor.coauthorÖzdemir, Levent
dc.contributor.coauthorSagün, Aslınur
dc.contributor.coauthorBoztug, Neval
dc.contributor.coauthorGündüz, Emel
dc.contributor.coauthorLafli-Tunay, Demet
dc.contributor.coauthorKarakaya, Deniz
dc.contributor.coauthorDost, Burhan
dc.contributor.coauthorKomurcu, Ozgur
dc.contributor.coauthorDilmen, Ozlem Korkmaz
dc.contributor.coauthorAkcil, Eren Fatma
dc.contributor.coauthorTunali, Yusuf
dc.contributor.coauthorOk, Gulay
dc.contributor.coauthorTok-Alsina, Eda
dc.contributor.coauthorPolat, Cengiz
dc.contributor.coauthorKızılcık, Nurcan
dc.contributor.coauthorŞen, Öznur
dc.contributor.coauthorDarçın, Kamil
dc.contributor.coauthorUğur, Semra
dc.contributor.coauthorGürkan, Yavuz
dc.contributor.coauthorSaracoglu, Kemal Tolga
dc.contributor.coauthorYıldız-Koyuncu, Özge
dc.contributor.coauthorDemir, Z. Aslı
dc.contributor.coauthorPostacı, N. Aysun
dc.contributor.coauthorÖzgök, Ayşegül
dc.contributor.coauthorKaradeniz, Ümit
dc.contributor.coauthorÖzay, Hülya Yiğit
dc.contributor.coauthorBalcı, Eda
dc.contributor.coauthorSalman, Nevriye
dc.contributor.coauthorGirgin, Behiç
dc.contributor.coauthorSagir, Ozlem
dc.contributor.coauthorDemir, Hafize Fisun
dc.contributor.coauthorUgun, Fatih
dc.contributor.coauthorToprak, Hüseyin İlksen
dc.contributor.coauthorÖzcan, Mustafa Soner
dc.contributor.coauthorAlkaya-Solmaz, Filiz
dc.contributor.coauthorYilmaz, Mehmet
dc.contributor.coauthorKaraca, Umran
dc.contributor.coauthorŞahin, Sevtap Hekimoglu
dc.contributor.coauthorErkoç, Süheyla Karadağ
dc.contributor.coauthorAlkış, Neslihan
dc.contributor.coauthorBaytaş, Volkan
dc.contributor.coauthorErturk, Engin
dc.contributor.coauthorSaylan, Sedat
dc.contributor.coauthorAkdogan, Ali
dc.contributor.coauthorYeşil, Beyza Büyükgebiz
dc.contributor.coauthorBoran, Omer Faruk
dc.contributor.coauthorOrak, Yavuz
dc.contributor.coauthorÇalişir, Feyza
dc.contributor.coauthorBüyükçoban, Sibel
dc.contributor.coauthorKuvaki, Bahar
dc.contributor.coauthorCansabuncu, Seda
dc.contributor.coauthorAkesen, Selcan
dc.contributor.coauthorGören, Suna
dc.contributor.coauthorYeniocak, Tugce
dc.contributor.coauthorOrman, Osman
dc.contributor.coauthorKarka, Özlem Ersoy
dc.contributor.coauthorSahin, Tulay
dc.contributor.coauthorMomot, Natalia
dc.contributor.coauthorPanchenko, Anna
dc.contributor.coauthorPittet, Jean-Francois
dc.contributor.coauthorRutledge, Kristen
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGürkan, Yavuz
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:31:20Z
dc.date.issued2024
dc.description.abstractPurpose: Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. Methods: We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. Results: We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21–3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. Conclusion: One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. © The Author(s) 2024.
dc.description.indexedbyScopus
dc.description.openaccessAll Open Access; Hybrid Gold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. The study was supported by the German Research Foundation (KFO342-1, ZA428/18-1, and ZA428/21-1 to AZ and ME5413/1-1 and ME5413/1-2 to MM) and by an unrestricted research grant from Baxter (to AZ).
dc.identifier.doi10.1007/s00134-023-07314-2
dc.identifier.issn3424642
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.1007/s00134-023-07314-2
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26222
dc.keywordsAcute kidney disease
dc.keywordsAcute kidney injury
dc.keywordsChronic kidney disease
dc.keywordsPostoperative
dc.keywordsSurgery
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland Gmbh
dc.relation.grantnoBaxter International; Deutsche Forschungsgemeinschaft, DFG, (KFO342-1, ME5413/1-1, ME5413/1-2, ZA428/18-1, ZA428/21-1); Deutsche Forschungsgemeinschaft, DFG
dc.relation.ispartofIntensive Care Medicine
dc.titleAcute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGürkan, Yavuz
local.contributor.kuauthorDarçın Kamil
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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