Publication: Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology
dc.contributor.coauthor | Elouej,Sahar | |
dc.contributor.coauthor | Harhouri, Karim | |
dc.contributor.coauthor | Le Mao, Morgane | |
dc.contributor.coauthor | Baujat, Genevieve | |
dc.contributor.coauthor | Nampoothiri, Sheela | |
dc.contributor.coauthor | Menabawy, Nihal Al | |
dc.contributor.coauthor | Selim, Laila | |
dc.contributor.coauthor | Paneque, Arianne Llamos | |
dc.contributor.coauthor | Kubisch, Christian | |
dc.contributor.coauthor | Lessel, Davor | |
dc.contributor.coauthor | Rubinsztajn,Robert | |
dc.contributor.coauthor | Charar, Chayki | |
dc.contributor.coauthor | Bartoli, Catherine | |
dc.contributor.coauthor | Airault, Coraline | |
dc.contributor.coauthor | Deleuze, Jean-François | |
dc.contributor.coauthor | Rötig, Agnes | |
dc.contributor.coauthor | Bauer, Peter | |
dc.contributor.coauthor | Pereira, Catarina | |
dc.contributor.coauthor | Loh, Abigail | |
dc.contributor.coauthor | Muchir, Antoine | |
dc.contributor.coauthor | Martino, Lisa | |
dc.contributor.coauthor | Gruenbaum, Yosef | |
dc.contributor.coauthor | Lee, Song-Hua | |
dc.contributor.coauthor | Manivet, Philippe | |
dc.contributor.coauthor | Lenaers, Guy | |
dc.contributor.coauthor | Lévy, Nicolas | |
dc.contributor.coauthor | De Sandre-Giovannoli, Annachiara | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Kayserili, Hülya | |
dc.contributor.kuauthor | Reversade, Bruno | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T11:52:23Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Mandibuloacral dysplasia syndromes are mainly due to recessive LMNA or ZMPSTE24 mutations, with cardinal nuclear morphological abnormalities and dysfunction. We report five homozygous null mutations in MTX2, encoding Metaxin-2 (MTX2), an outer mitochondrial membrane protein, in patients presenting with a severe laminopathy-like mandibuloacral dysplasia characterized by growth retardation, bone resorption, arterial calcification, renal glomerulosclerosis and severe hypertension. Loss of MTX2 in patients’ primary fibroblasts leads to loss of Metaxin-1 (MTX1) and mitochondrial dysfunction, including network fragmentation and oxidative phosphorylation impairment. Furthermore, patients’ fibroblasts are resistant to induced apoptosis, leading to increased cell senescence and mitophagy and reduced proliferation. Interestingly, secondary nuclear morphological defects are observed in both MTX2-mutant fibroblasts and mtx-2-depleted C. elegans. We thus report the identification of a severe premature aging syndrome revealing an unsuspected link between mitochondrial composition and function and nuclear morphology, establishing a pathophysiological link with premature aging laminopathies and likely explaining common clinical features. | |
dc.description.fulltext | YES | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Association Française contre les Myopathies (AFM) | |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft | |
dc.description.sponsorship | GENMED Laboratory of Excellence on Medical Genomics, Agence Nationale de la Recherche | |
dc.description.sponsorship | Institut National de la Santé et de la Recherche Médicale (INSERM) | |
dc.description.sponsorship | Aix-Marseille University (AMU) by the RAREMED Amidex Project | |
dc.description.version | Publisher version | |
dc.description.volume | 11 | |
dc.identifier.doi | 10.1038/s41467-020-18146-9 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR02405 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85090799320 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/740 | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group (NPG) | |
dc.relation.grantno | AFM grant MNH‐Decrypt 2011‐2015 and TRIM‐RD 2016‐2020 | |
dc.relation.grantno | LE4223/1-1 | |
dc.relation.grantno | ANR-10-LABX0013 | |
dc.relation.ispartof | Nature Communications | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9041 | |
dc.subject | Medicine | |
dc.title | Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Kayserili, Hülya | |
local.contributor.kuauthor | Beillard, Nathalie Sonia Escande | |
local.contributor.kuauthor | Reversade, Bruno | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |
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