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The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures

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dc.contributor.kuauthorSağ, Alan Alper
dc.contributor.kuauthorŞal, Oğuzhan
dc.contributor.kuauthorKılıç, Yağmur
dc.contributor.kuauthorÖnal, Emine Meltem
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokidN/A
dc.contributor.yokid341966
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid110580
dc.date.accessioned2024-11-09T23:50:15Z
dc.date.issued2017
dc.description.abstractThis review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessYES
dc.description.volume19
dc.identifier.doi10.1111/jch.12978
dc.identifier.eissn1751-7176
dc.identifier.issn1524-6175
dc.identifier.scopus2-s2.0-85013489228
dc.identifier.urihttp://dx.doi.org/10.1111/jch.12978
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14513
dc.identifier.wos401194600012
dc.keywordsDenervation
dc.keywordsHypertension
dc.keywordsEssential
dc.keywordsHypertension resistant to conventional therapy
dc.keywordsRadiology
dc.keywordsInterventional
dc.keywordsActivated protein-kinases
dc.keywordsRenin-angiotensin-system
dc.keywordsRenal-artery stenosis
dc.keywordsResistant hypertension
dc.keywordsKidney
dc.keywordsIdentification
dc.keywordsCombination
dc.keywordsThiazide
dc.languageEnglish
dc.publisherWiley
dc.sourceJournal of Clinical Hypertension
dc.subjectPeripheral vascular diseases
dc.titleThe concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0002-3106-0458
local.contributor.authorid0000-0002-8771-8263
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authorid0000-0002-1297-0675
local.contributor.kuauthorSağ, Alan Alper
local.contributor.kuauthorŞal, Oğuzhan
local.contributor.kuauthorKılıç, Yağmur
local.contributor.kuauthorÖnal, Emine Meltem
local.contributor.kuauthorKanbay, Mehmet

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