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The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures

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dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorKılıç, Yağmur
dc.contributor.kuauthorÖnal, Emine Meltem
dc.contributor.kuauthorSağ, Alan Alper
dc.contributor.kuauthorŞal, Oğuzhan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:50:15Z
dc.date.issued2017
dc.description.abstractThis review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessYES
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume19
dc.identifier.doi10.1111/jch.12978
dc.identifier.eissn1751-7176
dc.identifier.issn1524-6175
dc.identifier.scopus2-s2.0-85013489228
dc.identifier.urihttps://doi.org/10.1111/jch.12978
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14513
dc.identifier.wos401194600012
dc.keywordsDenervation
dc.keywordsHypertension
dc.keywordsEssential
dc.keywordsHypertension resistant to conventional therapy
dc.keywordsRadiology
dc.keywordsInterventional
dc.keywordsActivated protein-kinases
dc.keywordsRenin-angiotensin-system
dc.keywordsRenal-artery stenosis
dc.keywordsResistant hypertension
dc.keywordsKidney
dc.keywordsIdentification
dc.keywordsCombination
dc.keywordsThiazide
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Hypertension
dc.subjectPeripheral vascular diseases
dc.titleThe concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorSağ, Alan Alper
local.contributor.kuauthorŞal, Oğuzhan
local.contributor.kuauthorKılıç, Yağmur
local.contributor.kuauthorÖnal, Emine Meltem
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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