Publication:
Evaluation of left atrial appendage functions by transthoracic echocardiography and comparison with left atrial strain values in renal transplant candidates

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorElçioğlu, Betül Cengiz
dc.contributor.kuauthorAytekin, Vedat
dc.contributor.kuauthorBaydar, Onur
dc.contributor.kuauthorKılıç, Alparslan
dc.contributor.kuauthorYelken, Berna
dc.contributor.kuauthorAytekin, Saide
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:29:13Z
dc.date.issued2023
dc.description.abstractAim: The incidence of stroke in patients with chronic kidney disease (CKD) is increased independent of atrial arrhythmias. The goal of this study is to evaluate, left atrial appendage (LAA) functions by transthoracic echocardiography (TTE) and comparison with left atrial (LA) strain values in patients with in renal transplant candidates with end stage renal disease (ESRD) with sinus rhythm. Material and Methods: Fifty two renal transplant candidates and 60 age- and sex-matched healthy participants were included in the study. LAA emptying velocity (EV) was measured with pulse wave Doppler, early diastolic (LAA Em), contraction (LAA Am) and systolic (LAA Sm) velocities were measured using tissue Doppler imaging from parasternal short axis view. Atrial peak longitudinal strain (PLS), peak contraction strain (PCS) and conduit strain (CdS) were calculated using two dimensional speckle tracking echocardiography. Results: LAA EV, Am and Sm and LA PLS, PCS, CdS measurements were found to be significantly lower in the patient group compared to controls. LAA EV measurements showed a strong positive correlation with left atrial volume index (LAVI), LA PLS and LA PCS values, and a negative correlation with left ventricular (LV) diameters, and E/e' value. In the multivariate regression analysis LA PLS and LAVI were found to be independent factors for LAA EV. Conclusion: Our findings suggest that the evaluation of LAA functions with TTE may help determine the increased risk of developing atrial arrhythmias and ischemic stroke in renal transplant candidates. Supporting the current findings with larger studies may change the follow-up and treatment approaches in these patients. / Aim: The incidence of stroke in patients with chronic kidney disease (CKD) is increased independent of atrial arrhythmias. The goal of this study is to evaluate, left atrial appendage (LAA) functions by transthoracic echocardiography (TTE) and comparison with left atrial (LA) strain values in patients with in renal transplant candidates with end stage renal disease (ESRD) with sinus rhythm. Material and Methods: Fifty two renal transplant candidates and 60 age- and sex-matched healthy participants were included in the study. LAA emptying velocity (EV) was measured with pulse wave Doppler, early diastolic (LAA Em), contraction (LAA Am) and systolic (LAA Sm) velocities were measured using tissue Doppler imaging from parasternal short axis view. Atrial peak longitudinal strain (PLS), peak contraction strain (PCS) and conduit strain (CdS) were calculated using two dimensional speckle tracking echocardiography. Results: LAA EV, Am and Sm and LA PLS, PCS, CdS measurements were found to be significantly lower in the patient group compared to controls. LAA EV measurements showed a strong positive correlation with left atrial volume index (LAVI), LA PLS and LA PCS values, and a negative correlation with left ventricular (LV) diameters, and E/e' value. In the multivariate regression analysis LA PLS and LAVI were found to be independent factors for LAA EV. Conclusion: Our findings suggest that the evaluation of LAA functions with TTE may help determine the increased risk of developing atrial arrhythmias and ischemic stroke in renal transplant candidates. Supporting the current findings with larger studies may change the follow-up and treatment approaches in these patients.
dc.description.fulltextN/A
dc.description.indexedbyTR Dizin
dc.description.issue3
dc.description.openaccessN/A
dc.description.publisherscopeNational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume14
dc.identifier.doi10.18663/tjcl.1268990
dc.identifier.eissn2149-8296
dc.identifier.embargoN/A
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.18663/tjcl.1268990
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25854
dc.keywordsLeft atrial strain
dc.keywordsLeft atrial appendage functions
dc.keywordsEnd stage renal disease
dc.keywordsKidney transplantation / Sol atriyal strain
dc.keywordsSol atriyal apendiks fonksiyonu
dc.keywordsSon dönem böbrek yetersizliği
dc.keywordsBöbrek nakli
dc.language.isoeng
dc.publisherDNT Ortadoğu Yayıncılık AŞ
dc.relation.ispartofTurkish Journal of Clinics and Laboratory
dc.subjectMedicine
dc.titleEvaluation of left atrial appendage functions by transthoracic echocardiography and comparison with left atrial strain values in renal transplant candidates
dc.title.alternativeBöbrek nakli adaylarında transtorasik ekokardiyografi ile sol atriyal apendiks fonksiyonlarının değerlendirilmesi ve sol atriyal strain değerleri ile karşılaştırılması
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorElçioğlu, Betül Cengiz
local.contributor.kuauthorBaydar, Onur
local.contributor.kuauthorKılıç, Alparslan
local.contributor.kuauthorYelken, Berna
local.contributor.kuauthorAytekin, Saide
local.contributor.kuauthorAytekin, Vedat
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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