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Translational models of stress and resilience: an applied neuroscience methodology review

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dc.contributor.coauthorVaz A., Bordes J., Ünlü S., Sep M.S.C., Vinkers C.H., Pinto L.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAlbayrak, Zeynep Seda
dc.contributor.kuauthorÜnlü, Selen
dc.contributor.kuauthorEser, Hale Yapıcı
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:59:46Z
dc.date.issued2024
dc.description.abstractStress, encompassing psychological, physical, and physiological challenges, is an important factor affecting an individual's well-being and potentially leading to psychiatric, neurodegenerative, immune, and metabolic disorders. However, not everyone exposed to stress develops these conditions, highlighting the concept of resilience. Resilience is a dynamic process categorized into four dimensions: pre-existing resilience capacity, ongoing resilience processes, post-stress resilience outcomes, and recovery from psychopathologies. These dimensions involve genomic, cellular, and systemic interactions influenced by genetic factors, early life experiences, adult life experiences in addition to community/environmental factors, and health behaviors. The biological response to stress encompasses endocrine, autonomic, immunological, and behavioral components, modulated by stressor characteristics and individual traits. Due to the limitations in studying stress and resilience in humans, translational models using rodents and cell cultures are essential. Rodent models include acute, chronic, and traumatic stress paradigms, aiding the study of stress-related behavioral and molecular outcomes. Additionally, early life stress models, such as prenatal stress and maternal separation, provide insights into developmental impacts. In this review, first, rodent models for lifelong stress exposure will be summarized considering their validity, advantages, and limitations. Subsequently, an overview of models designed to enhance resilience capacity and process in rodents, and later the behavioral models employed to study the outcomes of resilience will be given. Lastly, the focus will be shifted to cell culture and iPSCs models. Finally, future considerations focused on improving translational models used to study stress and resilience will be discussed. It is aimed to provide an overview of designs for translational stress and resilience models to access more effective translational biomarkers associated with stress and resilience. Stress and resilience are complex phenomena influenced by various factors, spanning molecular to behavioral levels. Integrating data across dimensions remains crucial for unraveling the complexities of stress-related disorders and resilience.
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipStudies using the SI model have shown that these stressors cause increased anxiety-like behaviors, neurodevelopmental impairments, impaired social functioning, aggression, and schizophrenia-like behaviors (Nakama et al., 2023). The face validity of the SI animal model is supported by its ability to induce anxiety-like behavior, alterations in neurotransmitter systems, and changes in gene expression, which are relevant to human psychiatric conditions associated with ELS (Wall et al., 2012;Pan et al., 2009). The construct validity is supported by the ability of the model to induce reproducible, long-term changes in behavior and neurochemistry that are relevant to the study of neuropsychiatric disorders. The model can replicate key features of early-life stress, such as changes in the HPA axis and long-term changes in brain function and behavior (Fone and Porkess, 2008). Besides, this model has been used to study a wide range of stress-related biomarkers, including BDNF, CRH, and dopamine metabolites, which are implicated in the neurobiological effects of ELS (Fone and Porkess, 2008).Food, water, and sleep deprivation can threaten survival and body homeostasis. Deprivation paradigms capitalize on this to induce acute stress (Atrooz et al., 2021). Both food and water deprivation cause hormonal changes that resemble the stress response (Atrooz et al., 2021). Sleep deprivation can be induced by forced activity, gentle handling, or enriched environments and triggers an increase of oxidative stress and a proinflammatory response (Atrooz et al., 2021). In solitary housing, SI is a variation in the deprivation models that induce stress due to the lack of social support and interaction (Atrooz et al., 2021).We thank Mathias V. Schmidt for his contributions. JB expresses his gratitude to Dr. Anna Beyeler for her mentorship and unconditional support. HYE's studies are supported by Turkish Science Academy and TUB\u0130TAK (The Scientific and Technological Research Council of T\u00FCrkiye). During the preparation of this work the authors used chatGPT in order to shorten long versions of some sections. After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.The manuscript has also been checked with Grammarly for grammer corrections. Figures have been generated using bioRender. The authors are members of the Resilience Network of the European College of Neuropsychopharmacology.
dc.identifier.doi10.1016/j.nsa.2024.104064
dc.identifier.grantnoTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK; European College of Neuropsychopharmacology, ECNP; University of North Dakota Center for Rural Health, UND CRH
dc.identifier.issn2772-4085
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85207817683
dc.identifier.urihttps://doi.org/10.1016/j.nsa.2024.104064
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27761
dc.identifier.volume3
dc.keywordsAcute stress
dc.keywordsBehavior
dc.keywordsChronic stress
dc.keywordsResilience
dc.keywordsRodent
dc.keywordsStress
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Applied
dc.subjectPsychology
dc.titleTranslational models of stress and resilience: an applied neuroscience methodology review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAlbayrak, Zeynep Seda
local.contributor.kuauthorÜnlü, Selen
local.contributor.kuauthorEser, Hale Yapıcı
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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