Publication: The impact of the vitamin D and resveratrol administration on the stiffness and elasticity of T2DM rat aorta associated with the trace element and mineral levels
dc.contributor.coauthor | Anapali-Aykac, Merve | |
dc.contributor.coauthor | Ulutin, Turgut | |
dc.contributor.coauthor | Komurcu-Bayrak, Evrim | |
dc.contributor.coauthor | Kaya-Dagistanli, Fatma | |
dc.contributor.department | Department of Mechanical Engineering | |
dc.contributor.kuauthor | Ulusu, Nuriye Nuray | |
dc.contributor.kuauthor | Aydemir, Duygu | |
dc.contributor.kuauthor | Salman, Naveed | |
dc.contributor.kuauthor | Karimzadehkhouei, Mehrdad | |
dc.contributor.kuauthor | Alaca, Burhanettin Erdem | |
dc.contributor.other | Department of Mechanical Engineering | |
dc.contributor.researchcenter | Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM) | |
dc.contributor.researchcenter | Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM) | |
dc.contributor.researchcenter | n2STAR-Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research | |
dc.contributor.schoolcollegeinstitute | School of Medicine | |
dc.contributor.schoolcollegeinstitute | Graduate School of Health Sciences | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.date.accessioned | 2024-12-29T09:41:31Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Background: Type 2 diabetes mellitus (T2DM) is directly associated with increased aortic stiffness, reduced aortic elasticity, and aortic dissection, which are independent risk factors for cardiovascular death. Since Vit D and resveratrol have been reported due to their cardioprotective effects, in this study, we aim to evaluate the impact of Vit D and resveratrol treatment alone or in combination on the aortic health associated with trace element and mineral levels in a high-fructose diet/streptozotocin-induced T2DM model. Methods: We investigated biomechanical changes of the aorta samples via a custom-built stretcher, where trace element and mineral levels in aorta samples were determined via inductively coupled plasma mass spectrometry (ICP-MS) following acidic microwave digestion. Results: Vitamin D treatment ameliorated the adverse effects of T2DM on aortic stiffness, aortic elasticity, and relaxation modulus in diabetic rats. Trace element and mineral levels correlated with cardiovascular homeostasis, including Fe, Cu, Zn, Se, and Na, have been regulated upon Vit D treatment in diabetic and healthy rats. On the other hand, resveratrol treatment alone or in combination with Vit D did not show any positive effects on biomechanical properties and trace element metabolism of diabetic or healthy rats, according to our data. Conclusion: Vit D can be used in T2DM patients to protect their cardiovascular health and should be considered a promising targeted therapy approach via nanoparticles to target cardiovascular diseases in the future. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | International | |
dc.description.sponsors | The authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Head of Strategy and Budget. | |
dc.description.volume | 86 | |
dc.identifier.doi | 10.1016/j.jtemb.2024.127497 | |
dc.identifier.eissn | 1878-3252 | |
dc.identifier.issn | 0946-672X | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85198927441 | |
dc.identifier.uri | https://doi.org/10.1016/j.jtemb.2024.127497 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/23676 | |
dc.identifier.wos | 1276195700001 | |
dc.keywords | Diabetes | |
dc.keywords | Aorta | |
dc.keywords | Biomechanical changes | |
dc.keywords | Trace element | |
dc.keywords | Mineral | |
dc.language | en | |
dc.publisher | Elsevier Inc. | |
dc.source | Journal of Trace Elements in Medicine and Biology | |
dc.subject | Biochemistry and molecular biology | |
dc.subject | Endocrinology and metabolism | |
dc.title | The impact of the vitamin D and resveratrol administration on the stiffness and elasticity of T2DM rat aorta associated with the trace element and mineral levels | |
dc.type | Journal article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ulusu, Nuriye Nuray | |
local.contributor.kuauthor | Aydemir, Duygu | |
local.contributor.kuauthor | Salman, Naveed | |
local.contributor.kuauthor | Karimzadehkhouei, Mehrdad | |
local.contributor.kuauthor | Alaca, Burhanettin Erdem | |
relation.isOrgUnitOfPublication | ba2836f3-206d-4724-918c-f598f0086a36 | |
relation.isOrgUnitOfPublication.latestForDiscovery | ba2836f3-206d-4724-918c-f598f0086a36 |