Publication:
The impact of the vitamin D and resveratrol administration on the stiffness and elasticity of T2DM rat aorta associated with the trace element and mineral levels

dc.contributor.coauthorAnapali-Aykac, Merve
dc.contributor.coauthorUlutin, Turgut
dc.contributor.coauthorKomurcu-Bayrak, Evrim
dc.contributor.coauthorKaya-Dagistanli, Fatma
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.kuauthorAydemir, Duygu
dc.contributor.kuauthorSalman, Naveed
dc.contributor.kuauthorKarimzadehkhouei, Mehrdad
dc.contributor.kuauthorAlaca, Burhanettin Erdem
dc.contributor.otherDepartment of Mechanical Engineering
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.researchcenterKoç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM)
dc.contributor.researchcentern2STAR-Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteGraduate School of Health Sciences
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-12-29T09:41:31Z
dc.date.issued2024
dc.description.abstractBackground: Type 2 diabetes mellitus (T2DM) is directly associated with increased aortic stiffness, reduced aortic elasticity, and aortic dissection, which are independent risk factors for cardiovascular death. Since Vit D and resveratrol have been reported due to their cardioprotective effects, in this study, we aim to evaluate the impact of Vit D and resveratrol treatment alone or in combination on the aortic health associated with trace element and mineral levels in a high-fructose diet/streptozotocin-induced T2DM model. Methods: We investigated biomechanical changes of the aorta samples via a custom-built stretcher, where trace element and mineral levels in aorta samples were determined via inductively coupled plasma mass spectrometry (ICP-MS) following acidic microwave digestion. Results: Vitamin D treatment ameliorated the adverse effects of T2DM on aortic stiffness, aortic elasticity, and relaxation modulus in diabetic rats. Trace element and mineral levels correlated with cardiovascular homeostasis, including Fe, Cu, Zn, Se, and Na, have been regulated upon Vit D treatment in diabetic and healthy rats. On the other hand, resveratrol treatment alone or in combination with Vit D did not show any positive effects on biomechanical properties and trace element metabolism of diabetic or healthy rats, according to our data. Conclusion: Vit D can be used in T2DM patients to protect their cardiovascular health and should be considered a promising targeted therapy approach via nanoparticles to target cardiovascular diseases in the future.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsorsThe authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Head of Strategy and Budget.
dc.description.volume86
dc.identifier.doi10.1016/j.jtemb.2024.127497
dc.identifier.eissn1878-3252
dc.identifier.issn0946-672X
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85198927441
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2024.127497
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23676
dc.identifier.wos1276195700001
dc.keywordsDiabetes
dc.keywordsAorta
dc.keywordsBiomechanical changes
dc.keywordsTrace element
dc.keywordsMineral
dc.languageen
dc.publisherElsevier Inc.
dc.sourceJournal of Trace Elements in Medicine and Biology
dc.subjectBiochemistry and molecular biology
dc.subjectEndocrinology and metabolism
dc.titleThe impact of the vitamin D and resveratrol administration on the stiffness and elasticity of T2DM rat aorta associated with the trace element and mineral levels
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorUlusu, Nuriye Nuray
local.contributor.kuauthorAydemir, Duygu
local.contributor.kuauthorSalman, Naveed
local.contributor.kuauthorKarimzadehkhouei, Mehrdad
local.contributor.kuauthorAlaca, Burhanettin Erdem
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relation.isOrgUnitOfPublication.latestForDiscoveryba2836f3-206d-4724-918c-f598f0086a36

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