Arrhytmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and heart transplantation: case series

Abstract

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) usually originates from right ventricle, has a prevalence 1 in 1000 and leading cause of death in people aged less than 35 years of age, also desmosome mutations and family history can be seen in this disease. We reviewed the literature and described three patients with arrhythmogenic right ventricular dysplasia/ cardiomyopathy (ARVD/C). They had T wave inversion in chest leads V1 to V4 and had premature ventricular complexes of left bundle branch block and left axis deviation, or right bundle branch block (RBB) had implantable cardioverter defibrillator (ICD) implantation and fulfilled the task force criteria for diagnosis of ARVD/C. One patient had familial erythrocytosis and thrombus formation in the right atrium and the right ventricle. He was listed as status 1A and had 2 times phlebotomy during the hospitalization. The other patient had warfarin intoxication, and had hepatic congestion due to end-stage right heart failure. The third patient had a history of cerebrovascular event and had a family history of ARVD/C. All of our patients had the medical regimen for the management of ARVD/C. All of the patients were in NYHA Class III-IV while they admitted to our clinic and they had their final therapeutic option as an orthotopic heart transplantation and have a good quality of life.