Publication: Systematic review and meta-analysis of postexposure prophylaxis for Crimean-Congo hemorrhagic fever virus among healthcare workers
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KU Authors
Co-Authors
Keske, Şiran
Pshenichnaya, Natalia
Abuova, Gulzhan
Blumberg, Lucille
Gönen, Mehmet
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NO
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Abstract
We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0-0.03), and ribavirin use <= 48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0-0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection.
Source
Publisher
Centers for Disease Control and Prevention (CDP)
Subject
Immunology, Infectious diseases
Citation
Has Part
Source
Emerging Infectious Disease
Book Series Title
Edition
DOI
10.3201/eid2409.171709