Publication:
Systematic review and meta-analysis of postexposure prophylaxis for Crimean-Congo hemorrhagic fever virus among healthcare workers

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GRADUATE SCHOOL OF HEALTH SCIENCES
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SCHOOL OF MEDICINE
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Co-Authors

Keske, Şiran
Pshenichnaya, Natalia
Abuova, Gulzhan
Blumberg, Lucille
Gönen, Mehmet

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NO

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Abstract

We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0-0.03), and ribavirin use <= 48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0-0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection.

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Publisher

Centers for Disease Control and Prevention (CDP)

Subject

Immunology, Infectious diseases

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Has Part

Source

Emerging Infectious Disease

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DOI

10.3201/eid2409.171709

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