Publication:
Baseline characteristics predicting clinical outcomes and serious adverse events in middle-aged hypertensive women: a subanalysis of the SPRINT in women aged <65 years

dc.contributor.coauthorAydın, Volkan
dc.contributor.coauthorAkıcı, Ahmet
dc.contributor.coauthorAkman, Mehmet
dc.contributor.coauthorFak, Ali Serdar
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSakarya, Sibel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:30:28Z
dc.date.issued2020
dc.description.abstractBackground/aim: The predictability of clinical outcomes in hypertension in specific patient groups, especially underrepresented populations is the key to rational treatment. This study aimed to investigate the impact of baseline characteristics of <65-year-old hypertensive women with an increased risk of cardiovascular events, managed with standard- or intensive-approach, on their clinical outcomes and serious adverse events (SAEs). Materials and methods: Baseline characteristics of <65-year-old hypertensive women (n = 1247) in SPRINT, a multicenter randomized trial to compare standard and intensive antihypertensive treatment, were analyzed with Cox-regression method to determine potential predictors of the clinical outcomes and SAEs. The primary outcome was the composite of myocardial infarction (MI), non-MI acute coronary syndrome, stroke, heart failure, or cardiovascular death. Results: The primary outcome occurred in 3.1% and SAEs in 27.6% of the population. The treatment groups were similar in terms of the primary outcome, SAEs, or their individual components. The primary outcome occurred significantly more in current smokers vs. nonsmokers (HR: 2.85, 95% CI: 1.34-6.09). The subjects who were on aspirin in the intensive-group were significantly more likely to develop the primary outcome (HR: 3.17, 95% CI: 1.23-8.19) and MI (HR: 10.15, 95% CI: 1.19-86.88) compared with those not using aspirin. The risk of overall SAEs was significantly higher in blacks vs. nonblacks (HR: 1.27, 95% CI: 1.01-1.58), in current-smokers vs. nonsmokers (HR: 1.59, 95% CI: 1.23-2.05), and those with vs. without chronic kidney disease (CKD), (HR: 1.38, 95% CI: 1.08-1.77). The likelihood of SAEs significantly increased with age (HR: 1.04, 95% CI: 1.01-1.07). Conclusion: Smoking, aspirin, CKD, black race, and age seemed as important baseline characteristics in follow-up of <65-year-old hypertensive women, also depending on therapeutic strategy. Clinicians are expected to consider these critical parameters for effective antihypertensive management that promotes better outcomes in this middle-aged female population.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyTR Dizin
dc.description.issue5
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume50
dc.identifier.doi10.3906/sag-1907-144
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.scopus2-s2.0-85089899839
dc.identifier.urihttps://doi.org/10.3906/sag-1907-144
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12245
dc.identifier.wos566495700014
dc.keywordsHypertension
dc.keywordsMiddle-aged women
dc.keywordsIntensive pharmacotherapy
dc.keywordsCardiovascular
dc.keywordsEvents systolic blood-pressure
dc.keywordsCardiovascular risk
dc.keywordsSex-differences
dc.keywordsDrug-reactions
dc.keywordsHeart-disease
dc.keywordsObesity
dc.keywordsSmoking
dc.keywordsTrial
dc.keywordsMen
dc.keywordsPathogenesis
dc.language.isoeng
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.subjectMedicine
dc.subjectInternal medicine
dc.titleBaseline characteristics predicting clinical outcomes and serious adverse events in middle-aged hypertensive women: a subanalysis of the SPRINT in women aged <65 years
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSakarya, Sibel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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