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Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases

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SCHOOL OF MEDICINE
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Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these patients carry a known risk of recurrence in the liver regardless of initial therapy choice. Therefore, there is a demand for minimally invasive, non-surgical, personalized cancer treatments to preserve quality of life in the induction, consolidation, and maintenance phases of cancer therapy. This report aims to review evidence-based conceptual, pharma cological, and technological paradigm shifts in parenteral and percutaneous treatment strategies as well as forthcoming evidence regarding next-generation systemic, locoregional, and local treatment approaches for this patient population.

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Baishideng Publishing Group (BPG)

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Medicine, Gastroenterology and hepatology

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World Journal of Gastroenterology

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10.3748/wjg.v22.i11.3127

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