Publication: Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions
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KU-Authors
KU Authors
Co-Authors
Michel, Leo
Osypenko, Denys
Molina, Patricia
Mutlu, Kadir A.
Lecca, Salvatore
Hisatsune, Chihiro
Mikoshiba, Katsuhiko
Kikuchi, Toko
Yaksi, Emre
Volterra, Andrea
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No
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Abstract
Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.
Source
Publisher
Nature Portfolio
Subject
Biology, Multidisciplinary Sciences
Citation
Has Part
Source
Communications biology
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DOI
10.1038/s42003-025-08535-5
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CC BY (Attribution)
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Creative Commons license
Except where otherwised noted, this item's license is described as CC BY (Attribution)