Publication:
Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions

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dc.contributor.coauthorMichel, Leo
dc.contributor.coauthorOsypenko, Denys
dc.contributor.coauthorMolina, Patricia
dc.contributor.coauthorMutlu, Kadir A.
dc.contributor.coauthorLecca, Salvatore
dc.contributor.coauthorHisatsune, Chihiro
dc.contributor.coauthorMikoshiba, Katsuhiko
dc.contributor.coauthorKikuchi, Toko
dc.contributor.coauthorYaksi, Emre
dc.contributor.coauthorVolterra, Andrea
dc.contributor.coauthorMameli, Manuel
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorOther, Yakşi, Emre
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-09-10T04:58:42Z
dc.date.available2025-09-09
dc.date.issued2025
dc.description.abstractBehavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.
dc.description.fulltextYes
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyPubMed
dc.description.openaccessGold OA
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipSchweizerischer Nationalfonds zur Frderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) [SNSF (310030_212193)]; Canton of Vaud; State Secretariat for Education, Research and Innovation (SVEN) [314212]; Research Council of Norway FRIPRO [332640]; Centres of Excellence scheme
dc.description.versionPublished Version
dc.description.volume8
dc.identifier.doi10.1038/s42003-025-08535-5
dc.identifier.eissn2399-3642
dc.identifier.embargoNo
dc.identifier.filenameinventorynoIR06453
dc.identifier.issue1
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.1038/s42003-025-08535-5
dc.identifier.urihttps://hdl.handle.net/20.500.14288/30354
dc.identifier.wos001534300800003
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofCommunications biology
dc.relation.openaccessYes
dc.rightsCC BY (Attribution)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiology
dc.subjectMultidisciplinary Sciences
dc.titleCalcium dynamics in habenular astrocytes regulate active coping within behavioral transitions
dc.typeJournal Article
dspace.entity.typePublication
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