Publication:
Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

dc.contributor.coauthorWood, Laura D.
dc.contributor.coauthorBasturk, Olca
dc.contributor.coauthorBrosens, Lodewijk A. A.
dc.contributor.coauthorFukushima, Noriyoshi
dc.contributor.coauthorHong, Seung-Mo
dc.contributor.coauthorKim, Sung-Joo
dc.contributor.coauthorLee, Jae W.
dc.contributor.coauthorLuchini, Claudio
dc.contributor.coauthorNoe, Michael
dc.contributor.coauthorPitman, Martha B.
dc.contributor.coauthorScarpa, Aldo
dc.contributor.coauthorSinghi, Aatur D.
dc.contributor.coauthorTanaka, Mariko
dc.contributor.coauthorFurukawa, Toru
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:27:42Z
dc.date.issued2023
dc.description.abstractBackground: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.Methods: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.Results: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.Conclusions: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.(c) 2023 Published by Elsevier B.V. on behalf of IAP and EPC.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipWe thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839. The authors report no conflicts of interest.
dc.description.volume23
dc.identifier.doi10.1016/j.pan.2023.08.002
dc.identifier.eissn1424-3911
dc.identifier.issn1424-3903
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85168327292
dc.identifier.urihttps://doi.org/10.1016/j.pan.2023.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25587
dc.identifier.wos1108605600001
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnoSol Goldman Pancreatic Cancer Research Center; IPMN Global Foundation; Japan Society for the Promotion of Science KAKENHI Grant [JP22H02839]
dc.relation.ispartofPancreatology
dc.subjectGastroenterology and hepatology
dc.titleSystematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAdsay, Nazmi Volkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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