Publication: The detection of prostate cancer with magnetic resonance imaging-targeted prostate biopsies is superior with the transperineal vs the transrectal approach. A European Association of Urology-Young Academic Urologists Prostate Cancer Working Group multi-institutional study
dc.contributor.coauthor | Zattoni, Fabio | |
dc.contributor.coauthor | Marra, Giancarlo | |
dc.contributor.coauthor | Kasivisvanathan, Veeru | |
dc.contributor.coauthor | Grummet, Jeremy | |
dc.contributor.coauthor | Nandurkar, Rohan | |
dc.contributor.coauthor | Ploussard, Guillaume | |
dc.contributor.coauthor | Olivier, Jonathan | |
dc.contributor.coauthor | Chiu, Peter K. | |
dc.contributor.coauthor | Valerio, Massimo | |
dc.contributor.coauthor | Gontero, Paolo | |
dc.contributor.coauthor | Guo, Hongqian | |
dc.contributor.coauthor | Zhuang, Junlong | |
dc.contributor.coauthor | Barletta, Francesco | |
dc.contributor.coauthor | Leni, Riccardo | |
dc.contributor.coauthor | Frydenberg, Mark | |
dc.contributor.coauthor | Moon, Daniel | |
dc.contributor.coauthor | Hanegbi, Uri | |
dc.contributor.coauthor | Landaumailto, Adam | |
dc.contributor.coauthor | Snow, Ross | |
dc.contributor.coauthor | Apfelbeck, Maria | |
dc.contributor.coauthor | Kretschmer, Alexander | |
dc.contributor.coauthor | van den Bergh, Roderick | |
dc.contributor.coauthor | Novara, Giacomo | |
dc.contributor.coauthor | Briganti, Alberto | |
dc.contributor.coauthor | Dal Moro, Fabrizio | |
dc.contributor.coauthor | Gandaglia, Giorgio | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Tilki, Derya | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-03-06T21:01:40Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Purpose: Our aim was to evaluate whether transperineal (TP) MRI-targeted prostate biopsy (TBx) may improve the detection of clinically significant prostate cancer (csPCa), defined as International Society of Urological Pathology >= 2, in comparison to transrectal (TR) TBx. Materials and Methods: A multicenter retrospective cohort study comprising patients who underwent MRIguided prostate biopsy was conducted. To address possible benefits of TP-TBx in the detection of prostate cancer (PCa) and csPCa, a cohort of patients undergoing TP-TBx were compared to patients undergoing TRTBx. Multivariable logistic regression analyses were performed to assess predictors of PCa and csPCa detection. Results: Overall, 1,936 and 3,305 patients who underwent TR-TBx vs TP-TBx at 10 referral centers were enrolled. The rate of PCa and csPCa diagnosed was higher for TP-TBx vs TR-TBx (64.0% vs 50%, p <0.01 and 49% vs 35%, p <0.01). At multivariable analysis adjusted for age, biopsy naive/repeated biopsy, cT stage, Prostate ImagingeReporting and Data System (R), prostate volume, PSA, and number of biopsy cores targeted, TP-TBx was an independent predictor of PCa (odds ratio [OR] 1.37, 95% CI 1.08-1.72) and csPCa (1.19, 95% CI 1.12-1.50). When considering the approach according to the site of the index lesion, TP-TBx had a significantly higher likelihood than TR-TBx to detect csPCa in the apex (OR 4.81, 95% CI 1.03-6.27), transition/central zone (OR 2.67, 95% CI 1.42-5.00), and anterior zone (OR 5.62, 95% CI 1.74-8.13). Conclusions: The use of TP-TBx allows a better cancer grade definition and PCa risk assessment. This has important implication in the decision-making process and in patient counseling for further therapies. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.identifier.doi | 10.1097/JU.0000000000002802 | |
dc.identifier.eissn | 1527-3792 | |
dc.identifier.issn | 0022-5347 | |
dc.identifier.issue | 4 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85137596426 | |
dc.identifier.uri | https://doi.org/10.1097/JU.0000000000002802 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/28023 | |
dc.identifier.volume | 208 | |
dc.identifier.wos | 923367400027 | |
dc.keywords | Prostatic neoplasms | |
dc.keywords | Diagnosis | |
dc.keywords | Biopsy | |
dc.keywords | Needle | |
dc.keywords | Magnetic resonance imaging | |
dc.keywords | Multiparametric magnetic resonance imaging | |
dc.language.iso | eng | |
dc.publisher | American Urological Association Education and Research, Inc. | |
dc.relation.ispartof | Journal of Urology | |
dc.subject | Ultrasound fusion | |
dc.subject | Guided biopsy | |
dc.title | The detection of prostate cancer with magnetic resonance imaging-targeted prostate biopsies is superior with the transperineal vs the transrectal approach. A European Association of Urology-Young Academic Urologists Prostate Cancer Working Group multi-institutional study | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Tilki, Derya | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |