Publication:
The detection of prostate cancer with magnetic resonance imaging-targeted prostate biopsies is superior with the transperineal vs the transrectal approach. A European Association of Urology-Young Academic Urologists Prostate Cancer Working Group multi-institutional study

dc.contributor.coauthorZattoni, Fabio
dc.contributor.coauthorMarra, Giancarlo
dc.contributor.coauthorKasivisvanathan, Veeru
dc.contributor.coauthorGrummet, Jeremy
dc.contributor.coauthorNandurkar, Rohan
dc.contributor.coauthorPloussard, Guillaume
dc.contributor.coauthorOlivier, Jonathan
dc.contributor.coauthorChiu, Peter K.
dc.contributor.coauthorValerio, Massimo
dc.contributor.coauthorGontero, Paolo
dc.contributor.coauthorGuo, Hongqian
dc.contributor.coauthorZhuang, Junlong
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorLeni, Riccardo
dc.contributor.coauthorFrydenberg, Mark
dc.contributor.coauthorMoon, Daniel
dc.contributor.coauthorHanegbi, Uri
dc.contributor.coauthorLandaumailto, Adam
dc.contributor.coauthorSnow, Ross
dc.contributor.coauthorApfelbeck, Maria
dc.contributor.coauthorKretschmer, Alexander
dc.contributor.coauthorvan den Bergh, Roderick
dc.contributor.coauthorNovara, Giacomo
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorDal Moro, Fabrizio
dc.contributor.coauthorGandaglia, Giorgio
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T21:01:40Z
dc.date.issued2022
dc.description.abstractPurpose: Our aim was to evaluate whether transperineal (TP) MRI-targeted prostate biopsy (TBx) may improve the detection of clinically significant prostate cancer (csPCa), defined as International Society of Urological Pathology >= 2, in comparison to transrectal (TR) TBx. Materials and Methods: A multicenter retrospective cohort study comprising patients who underwent MRIguided prostate biopsy was conducted. To address possible benefits of TP-TBx in the detection of prostate cancer (PCa) and csPCa, a cohort of patients undergoing TP-TBx were compared to patients undergoing TRTBx. Multivariable logistic regression analyses were performed to assess predictors of PCa and csPCa detection. Results: Overall, 1,936 and 3,305 patients who underwent TR-TBx vs TP-TBx at 10 referral centers were enrolled. The rate of PCa and csPCa diagnosed was higher for TP-TBx vs TR-TBx (64.0% vs 50%, p <0.01 and 49% vs 35%, p <0.01). At multivariable analysis adjusted for age, biopsy naive/repeated biopsy, cT stage, Prostate ImagingeReporting and Data System (R), prostate volume, PSA, and number of biopsy cores targeted, TP-TBx was an independent predictor of PCa (odds ratio [OR] 1.37, 95% CI 1.08-1.72) and csPCa (1.19, 95% CI 1.12-1.50). When considering the approach according to the site of the index lesion, TP-TBx had a significantly higher likelihood than TR-TBx to detect csPCa in the apex (OR 4.81, 95% CI 1.03-6.27), transition/central zone (OR 2.67, 95% CI 1.42-5.00), and anterior zone (OR 5.62, 95% CI 1.74-8.13). Conclusions: The use of TP-TBx allows a better cancer grade definition and PCa risk assessment. This has important implication in the decision-making process and in patient counseling for further therapies.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1097/JU.0000000000002802
dc.identifier.eissn1527-3792
dc.identifier.issn0022-5347
dc.identifier.issue4
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85137596426
dc.identifier.urihttps://doi.org/10.1097/JU.0000000000002802
dc.identifier.urihttps://hdl.handle.net/20.500.14288/28023
dc.identifier.volume208
dc.identifier.wos923367400027
dc.keywordsProstatic neoplasms
dc.keywordsDiagnosis
dc.keywordsBiopsy
dc.keywordsNeedle
dc.keywordsMagnetic resonance imaging
dc.keywordsMultiparametric magnetic resonance imaging
dc.language.isoeng
dc.publisherAmerican Urological Association Education and Research, Inc.
dc.relation.ispartofJournal of Urology
dc.subjectUltrasound fusion
dc.subjectGuided biopsy
dc.titleThe detection of prostate cancer with magnetic resonance imaging-targeted prostate biopsies is superior with the transperineal vs the transrectal approach. A European Association of Urology-Young Academic Urologists Prostate Cancer Working Group multi-institutional study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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