Publication:
TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry

Placeholder

School / College / Institute

Organizational Unit

Program

KU Authors

Co-Authors

Guven-Maiorov, Emine
VanWaes, Carter
Chen, Zhong
Tsai, Chung-Jung
Nussinov, Ruth

Publication Date

Language

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Background: The tumor necrosis factor receptor (TNFR) associated factor 3 (TRAF3) is a key node in innate and adaptive immune signaling pathways. TRAF3 negatively regulates the activation of the canonical and non canonical NF-kappa B pathways and is one of the key proteins in antiviral immunity. Scope of Review: Here we provide a structural overview of TRAF3 signaling in terms of its competitive binding and consequences to the cellular network. For completion, we also include molecular mimicry of TRAF3 physiological partners by some viral proteins. Major Conclusions: By out-competing host partners, viral proteins aim to subvert TRAF3 antiviral action. Mechanistically, dynamic, competitive binding by the organism's own proteins and same-site adaptive pathogen mimicry follow the same conformational selection principles. General Significance: Our premise is that irrespective of the eliciting event - physiological or acquired pathogenic trait - pathway activation (or suppression) may embrace similar conformational principles. However, even though here we largely focus on competitive binding at a shared site, similar to physiological signaling other pathogen subversion mechanisms can also be at play. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang.

Source

Publisher

Elsevier

Subject

Biochemistry, Molecular Biology, Biophysics

Citation

Has Part

Source

Biochimica et Biophysica Acta-General Subjects

Book Series Title

Edition

DOI

10.1016/j.bbagen.2016.05.021

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads

View PlumX Details