Publication:
The Impact of Hypertonic Dextrose on Dura Mater Regeneration and Fibroblast Activity Following Experimental Cerebrospinal Fluid Leakage

Simple item page
dc.contributor.coauthorŞahin, Omer Faruk (56371266400)
dc.contributor.coauthorTaşcioǧlu, Tuncer (55312173900)
dc.contributor.coauthorFirat, Ayşegül (35104794500)
dc.contributor.coauthorSelçuk Sürücü, H. (6506519718)
dc.contributor.coauthorÇaydere, Muzaffer Ver (57188802983)
dc.contributor.coauthorCemil, Duran Berker (59471603200)
dc.date.accessioned2025-12-31T08:24:50Z
dc.date.available2025-12-31
dc.date.issued2025
dc.description.abstractAIM: To investigate the effects of 25% dextrose in a rat model of cerebrospinal fluid leakage. MATERIAL and METHODS: Forty Wistar rats were included in the study. The dura mater of the rats was opened, and 25% dextrose was applied topically at a dose of 0.1 ml. Rats were sacrificed at the end of the third and sixth weeks. Then, pathologic and electron microscopic evaluations were performed. RESULTS: The results of healing score and fibroblast density evaluations showed that dextrose led to more successful healing than control subjects in early and late postoperative evaluations. In addition, electron microscopic examination showed that fibroblasts had active endoplasmic reticulum and mitochondria in a large cytoplasm, indicating increased collagen secretion. CONCLUSION: After dura mater injury, 25% dextrose, a cheap and accessible agent, has the potential to be used to enhance healing. © This work is licensed by “Creative Commons Attribution-NonCommercial-4.0 International (CC)".
dc.description.fulltextYes
dc.description.harvestedfromManual
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.5137/1019-5149.JTN.49101-25.3
dc.identifier.embargoNo
dc.identifier.endpage845
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.pubmed41165393
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-105022821703
dc.identifier.startpage839
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.49101-25.3
dc.identifier.urihttps://hdl.handle.net/20.500.14288/31828
dc.identifier.volume35
dc.keywordsCerebrospinal fluid leak
dc.keywordsHypertonic glucose
dc.keywordsRat
dc.keywordsWound healing
dc.language.isoeng
dc.publisherTurkish Neurosurgical Society
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofTurkish Neurosurgery
dc.relation.openaccessYes
dc.rightsCC BY-NC-ND (Attribution-NonCommercial-NoDerivs)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleThe Impact of Hypertonic Dextrose on Dura Mater Regeneration and Fibroblast Activity Following Experimental Cerebrospinal Fluid Leakage
dc.typeJournal Article
dspace.entity.typePublication

Files

Collections

Publications without Fulltext