Publication:
Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states

dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorMallamaci, Francesca
dc.contributor.coauthorZoccali, Carmine
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorGüldan, Mustafa
dc.contributor.kuauthorHatipoğlu, Alper
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorÖzbek, Laşin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:58Z
dc.date.issued2024
dc.description.abstractThe role of proximal tubules (PTs), a major component of the renal tubular structure in the renal cortex, has been examined extensively. Along with its physiological role in the reabsorption of various molecules, including electrolytes, amino acids and monosaccharides, transcellular transport of different hormones and regulation of homeostasis, pathological events affecting PTs may underlie multiple disease states. PT hypertrophy or a hyperfunctioning state, despite being a compensatory mechanism at first in response to various stimuli or alterations at tubular transport proteins, have been shown to be critical pathophysiological events leading to multiple disorders, including diabetes mellitus, obesity, metabolic syndrome and congestive heart failure. Moreover, pharmacotherapeutic agents have primarily targeted PTs, including sodium-glucose cotransporter 2, urate transporters and carbonic anhydrase enzymes. In this narrative review, we focus on the physiological role of PTs in healthy states and the current understanding of the PT pathologies leading to disease states and potential therapeutic targets.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.openaccessgold
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe figures were crafted at biorender.com.
dc.description.volume17
dc.identifier.doi10.1093/ckj/sfae195
dc.identifier.eissn2048-8513
dc.identifier.issn2048-8505
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85199672209
dc.identifier.urihttps://doi.org/10.1093/ckj/sfae195
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22203
dc.identifier.wos1275411300003
dc.keywordsChronic kidney disease
dc.keywordsDiabetes mellitus
dc.keywordsProximal tubules
dc.keywordsSodium-glucose cotransporter 2 (SGLT2)
dc.keywordsTubular hypertrophy
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofClinical Kidney Journal
dc.subjectUrology and nephrology
dc.titleProximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorGüldan, Mustafa
local.contributor.kuauthorÖzbek, Laşin
local.contributor.kuauthorHatipoğlu, Alper
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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