Publication:
Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

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dc.contributor.coauthorRahbarghazi, Reza
dc.contributor.kuauthorRajabi, Hadi
dc.contributor.kuauthorKonyalılar, Nur
dc.contributor.kuauthorErkan, Sinem
dc.contributor.kuauthorMortazavi, Deniz
dc.contributor.kuauthorKorkunç, Seval Kübra
dc.contributor.kuauthorKayalar, Özgecan
dc.contributor.kuauthorBayram, Hasan
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileResearcher
dc.contributor.kuprofileFaculty Member
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.schoolcollegeinstituteGraduate School of Health Sciences
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid4890
dc.date.accessioned2024-11-09T12:46:20Z
dc.date.issued2022
dc.description.abstractChronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipKoç University Translational Medicine Research Center (KUTTAM)
dc.description.versionPublisher version
dc.description.volume13
dc.formatpdf
dc.identifier.doi10.1186/s13287-022-02820-4
dc.identifier.eissn1757-6512
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03640
dc.identifier.linkhttps://doi.org/10.1186/s13287-022-02820-4
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85127493313
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2472
dc.identifier.wos778005000002
dc.keywordsCOPD
dc.keywordsImmune cells
dc.keywordsExosomes
dc.keywordsPathological remodeling
dc.keywordsTissue regeneration
dc.languageEnglish
dc.publisherBioMed Central
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10497
dc.sourceStem Cell Research and Therapy
dc.subjectCell and tissue Engineering
dc.subjectCell biology
dc.subjectMedicine, research and experimental
dc.titleEmerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
dc.typeReview
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authorid0000-0002-5236-766X
local.contributor.kuauthorRajabi, Hadi
local.contributor.kuauthorKonyalılar, Nur
local.contributor.kuauthorErkan, Sinem
local.contributor.kuauthorMortazavi, Deniz
local.contributor.kuauthorKorkunç, Seval Kübra
local.contributor.kuauthorKayalar, Özgecan
local.contributor.kuauthorBayram, Hasan

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