Publication:
A brief atlas of insulin

dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUIS AI (Koç University & İş Bank Artificial Intelligence Center)
dc.contributor.kuauthorAyan, Esra
dc.contributor.kuauthorDemirci, Hasan
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-10T00:01:05Z
dc.date.issued2022
dc.description.abstractInsulin is an essential factor for mammalian organisms: a regulator of glucose metabolism and other key signaling pathways. Insulin is also a multifunctional hormone whose absence can cause many diseases. Recombinant insulin is widely used in the treatment of diabetes. Understanding insulin, biosimilars, and biobetters from a holistic perspective will help pharmacologically user-friendly molecules design and develop personalized medicine-oriented therapeutic strategies for diabetes. Additionally, it helps to understand the underlying mechanism of other insulin-dependent metabolic disorders. The purpose of this atlas is to review insulin from a biotechnologi-cal, basic science, and clinical perspective, explain nearly all insulin-related disorders and their underlying molecular mechanisms, explore exogenous/recombinant production strategies of patented and research-level insulin/analogs, and highlight their mechanism of action from a structural per-spective. Combined with computational analysis, comparisons of insulin and analogs also provide novel information about the structural dynamics of insulin.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume19
dc.identifier.doi10.2174/1573399819666220610150342
dc.identifier.eissn1875-6417
dc.identifier.issn1573-3998
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85153855936
dc.identifier.urihttps://doi.org/10.2174/1573399819666220610150342
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15911
dc.identifier.wos1015052000006
dc.keywordsDiabetes
dc.keywordsInsulin
dc.keywordsInsulin analogs
dc.keywordsInsulin dynamics
dc.keywordsInsulin structures
dc.keywordsRecombinant insulin
dc.language.isoN/A
dc.publisherBentham Science
dc.relation.ispartofCurrent Diabetes Reviews
dc.subjectDiabetes mellitus
dc.titleA brief atlas of insulin
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAyan, Esra
local.contributor.kuauthorDemirci, Hasan
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Sciences
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Molecular Biology and Genetics
local.publication.orgunit2KUIS AI (Koç University & İş Bank Artificial Intelligence Center)
local.publication.orgunit2Graduate School of Sciences and Engineering
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