Publication:
A brief atlas of insulin

dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.kuauthorAyan, Esra
dc.contributor.kuauthorDemirci, Hasan
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileFaculty Member
dc.contributor.yokidN/A
dc.contributor.yokid307350
dc.date.accessioned2024-11-10T00:01:05Z
dc.date.issued2022
dc.description.abstractInsulin is an essential factor for mammalian organisms: a regulator of glucose metabolism and other key signaling pathways. Insulin is also a multifunctional hormone whose absence can cause many diseases. Recombinant insulin is widely used in the treatment of diabetes. Understanding insulin, biosimilars, and biobetters from a holistic perspective will help pharmacologically user-friendly molecules design and develop personalized medicine-oriented therapeutic strategies for diabetes. Additionally, it helps to understand the underlying mechanism of other insulin-dependent metabolic disorders. The purpose of this atlas is to review insulin from a biotechnologi-cal, basic science, and clinical perspective, explain nearly all insulin-related disorders and their underlying molecular mechanisms, explore exogenous/recombinant production strategies of patented and research-level insulin/analogs, and highlight their mechanism of action from a structural per-spective. Combined with computational analysis, comparisons of insulin and analogs also provide novel information about the structural dynamics of insulin.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume19
dc.identifier.doi10.2174/1573399819666220610150342
dc.identifier.eissn1875-6417
dc.identifier.issn1573-3998
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85153855936
dc.identifier.urihttp://dx.doi.org/10.2174/1573399819666220610150342
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15911
dc.identifier.wos1015052000006
dc.keywordsDiabetes
dc.keywordsInsulin
dc.keywordsInsulin analogs
dc.keywordsInsulin dynamics
dc.keywordsInsulin structures
dc.keywordsRecombinant insulin
dc.languageN/A
dc.publisherBentham Science
dc.sourceCurrent Diabetes Reviews
dc.subjectDiabetes mellitus
dc.titleA brief atlas of insulin
dc.typeReview
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.authorid0000-0002-9135-5397
local.contributor.kuauthorAyan, Esra
local.contributor.kuauthorDemirci, Hasan
local.publication.orgunit1Graduate School of Sciences and Engineering
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Molecular Biology and Genetics
local.publication.orgunit2KUIS AI (Koç University & İş Bank Artificial Intelligence Center)
relation.isOrgUnitOfPublicationaee2d329-aabe-4b58-ba67-09dbf8575547
relation.isOrgUnitOfPublication.latestForDiscoveryaee2d329-aabe-4b58-ba67-09dbf8575547

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