Publication:
Zinc improved erythrocyte deformability and aggregation in patients with beta-thalassemia: an in vitro study

dc.contributor.coauthorSinan, Mukaddes
dc.contributor.coauthorKarakas, Zeynep
dc.contributor.coauthorErtan, Nesrin Zeynep
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGöksel, Evrim
dc.contributor.kuauthorYalçın, Özlem
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:58Z
dc.date.issued2023
dc.description.abstractBACKGROUND: Thalassemia patients have reduced red cell deformability and decreased plasma zinc levels in their blood. OBJECTIVE: This study aimed to evaluate the effects of zinc (Zn) on the hemorheological parameters and antioxidant enzyme activities in mu-thalassemia major (TM) and healthy volunteers (HV). METHODS: Hemorheological parameters were measured usingLORCA(laser-assisted optical rotational cell analyzer) after adjusting the hematocrit to 40%. Zinc sulfate (ZnSO4.7H(2)O) was used for Zn incubation with a concentration of 0.5 mu g/dl. Oxidative stress and antioxidant status were determined using commercial kits. RESULTS: Data showed that after Zn incubation, EImax, the area under the EI-osmolarity curve (Area), and Omax decreased in TM. However, no significant difference was observed in the osmotic deformability parameters of HV. The increased elongation index was obtained at different shear stresses for TM and HV, and SS1/ 2 decreased in both groups. The AMP and aggregation index (AI) decreased in TM, and the required time for half of the maximum aggregation (t1/2) increased in HV. However, Zn did not affect oxidative parameters in both groups. CONCLUSIONS: This study showed that Zn incubation increased deformability and decreased aggregation in thalassemic erythrocytes. It means that Zn supplementation will contribute to microcirculation in thalassemia patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was established from a Ph.D. thesis (Mukaddes Sinan) in Istanbul University, Institute of Graduate Studies of Health Sciences, and was supported by The Research Foundation of Istanbul University with a research number of 31192.
dc.description.volume85
dc.identifier.doi10.3233/CH-221452
dc.identifier.eissn1875-8622
dc.identifier.issn1386-0291
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85173588188
dc.identifier.urihttps://doi.org/10.3233/CH-221452
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22199
dc.identifier.wos1085846400001
dc.keywordsThalassemia
dc.keywordsZinc
dc.keywordsErythrocyte aggregation
dc.keywordsDeformability
dc.keywordsOsmotic deformability
dc.keywordsAntioxidant
dc.language.isoeng
dc.publisherIOS Press
dc.relation.grantnoResearch Foundation of Istanbul University [31192]
dc.relation.ispartofClinical Hemorheology and Microcirculation
dc.subjectHematology
dc.subjectPeripheral vascular disease
dc.titleZinc improved erythrocyte deformability and aggregation in patients with beta-thalassemia: an in vitro study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYalçın, Özlem
local.contributor.kuauthorGöksel, Evrim
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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