Publication: Role of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants
dc.contributor.coauthor | Topcuoglu, Sevilay | |
dc.contributor.coauthor | Arslanbuga, Cansev | |
dc.contributor.coauthor | Aktas, Alev | |
dc.contributor.coauthor | Karatekin, Guner | |
dc.contributor.coauthor | Uluhan, Ramazan | |
dc.contributor.coauthor | Ovali, Fahri | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Gürsoy, Tuğba | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:43:07Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Objective: One of the most challenging aspects in the management of neonates with late-onset neonatal sepsis (LOS) is to make the diagnosis. Presepsin is a novel and promising marker of sepsis. The aim of this study was to assess the role of presepsin in the diagnosis of LOS in preterm infants.Methods: Forty-two premature newborns 32 weeks gestational age with a diagnosis of LOS were prospectively involved in the study. Forty gestational and postnatal age-matched infants without sepsis served as controls. Levels of presepsin, C-reactive protein, and procalcitonin were measured at enrollment and on the third and seventh days of sepsis.Results: Initial presepsin levels in the LOS group were significantly higher than in the control group (1024pg/mL, min-max: 295-8202; versus 530pg/mL, min-max: 190-782; p<0.0001). The area under the receiver-operating curve for presepsin was 0.864. A presepsin value of 800.5pg/mL was established as a cut-off value, with 67% sensitivity and 100% specificity. Presepsin levels gradually decreased during treatment.Conclusion: Presepsin can be used as a reliable biomarker for LOS and treatment response in preterm infants. However, we could not demonstrate the efficacy of presepsin for the detection of disease severity or prognosis. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 11 | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 29 | |
dc.identifier.doi | 10.3109/14767058.2015.1064885 | |
dc.identifier.eissn | 1476-4954 | |
dc.identifier.issn | 1476-7058 | |
dc.identifier.scopus | 2-s2.0-84938832977 | |
dc.identifier.uri | https://doi.org/10.3109/14767058.2015.1064885 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/13440 | |
dc.identifier.wos | 373515800026 | |
dc.keywords | Late-onset sepsis | |
dc.keywords | Newborn | |
dc.keywords | Premature | |
dc.keywords | Presepsin soluble CD14 subtype | |
dc.keywords | Birth | |
dc.keywords | Mortality | |
dc.keywords | Newborns | |
dc.keywords | SCD14-ST | |
dc.keywords | Protein | |
dc.keywords | Utility | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis Ltd | |
dc.relation.ispartof | Journal of Maternal-Fetal & Neonatal Medicine | |
dc.subject | Obstetrics | |
dc.subject | Gynecology | |
dc.title | Role of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Gürsoy, Tuğba | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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