Publication:
Role of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants

dc.contributor.coauthorTopcuoglu, Sevilay
dc.contributor.coauthorArslanbuga, Cansev
dc.contributor.coauthorAktas, Alev
dc.contributor.coauthorKaratekin, Guner
dc.contributor.coauthorUluhan, Ramazan
dc.contributor.coauthorOvali, Fahri
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGürsoy, Tuğba
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:43:07Z
dc.date.issued2016
dc.description.abstractObjective: One of the most challenging aspects in the management of neonates with late-onset neonatal sepsis (LOS) is to make the diagnosis. Presepsin is a novel and promising marker of sepsis. The aim of this study was to assess the role of presepsin in the diagnosis of LOS in preterm infants.Methods: Forty-two premature newborns 32 weeks gestational age with a diagnosis of LOS were prospectively involved in the study. Forty gestational and postnatal age-matched infants without sepsis served as controls. Levels of presepsin, C-reactive protein, and procalcitonin were measured at enrollment and on the third and seventh days of sepsis.Results: Initial presepsin levels in the LOS group were significantly higher than in the control group (1024pg/mL, min-max: 295-8202; versus 530pg/mL, min-max: 190-782; p<0.0001). The area under the receiver-operating curve for presepsin was 0.864. A presepsin value of 800.5pg/mL was established as a cut-off value, with 67% sensitivity and 100% specificity. Presepsin levels gradually decreased during treatment.Conclusion: Presepsin can be used as a reliable biomarker for LOS and treatment response in preterm infants. However, we could not demonstrate the efficacy of presepsin for the detection of disease severity or prognosis.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue11
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume29
dc.identifier.doi10.3109/14767058.2015.1064885
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.scopus2-s2.0-84938832977
dc.identifier.urihttps://doi.org/10.3109/14767058.2015.1064885
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13440
dc.identifier.wos373515800026
dc.keywordsLate-onset sepsis
dc.keywordsNewborn
dc.keywordsPremature
dc.keywordsPresepsin soluble CD14 subtype
dc.keywordsBirth
dc.keywordsMortality
dc.keywordsNewborns
dc.keywordsSCD14-ST
dc.keywordsProtein
dc.keywordsUtility
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.subjectObstetrics
dc.subjectGynecology
dc.titleRole of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGürsoy, Tuğba
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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