Publication:
Capecitabine-induced bilateral ectropion: a rare ocular manifestation requiring surgical intervention

dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorMüftüoğlu, Orkun
dc.contributor.kuauthorÖzmen, Selahattin
dc.contributor.kuauthorSezgin, Billur
dc.contributor.kuauthorTaş, Ayşe Yıldız
dc.contributor.kuauthorTatar, Sedat
dc.contributor.kuauthorYalçın, Can Ege
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:13:12Z
dc.date.issued2018
dc.description.abstractIt has been established that many chemotherapeutic agents are associated with a variety of ocular side effects. As an antineoplastic agent, 5-fluorouracil (5-FU) is the chemotherapeutic agent that is frequently linked with cicatricial ectropion. Capecitabine is a prodrug of 5-FU and has a more favorable side effect profile than 5-FU. Frequent side effects of capecitabine include gastrointestinal events and hand-foot-mouth syndrome; cicatricial ectropion is rather uncommon. Enzyme deficiencies affecting the capecitabine metabolism have been reported to be associated with exaggerated generalized systemic and cutaneous side effects; however, there are no cases in the literature reporting capecitabine-induced isolated bilateral-progressive ectropion. Although cessation of the agent is frequently sufficient for the treatment of ectropion, close follow-up is indicated in such patients as permanent damage may occur if the problem is left untreated. We report a case of capecitabine-induced bilateral cicatricial ectropion refractory to treatment cessation, ultimately requiring surgical treatment.
dc.description.fulltextYES
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume16
dc.identifier.doi10.4103/JCAS.JCAS_5_18
dc.identifier.eissn0974-5157
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00911
dc.identifier.issn0974-2077
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85061306554
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2930
dc.keywordsCystoid macular
dc.keywords5-fluorouracil
dc.keywordsCapecitabine
dc.keywordsEctropion
dc.keywordsSkin grafting
dc.language.isoeng
dc.publisherMedknow Publications
dc.relation.ispartofJournal of Cutaneous and Aesthetic Surgery
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8157
dc.subjectMedicine
dc.subjectMacular edema
dc.subjectEye
dc.titleCapecitabine-induced bilateral ectropion: a rare ocular manifestation requiring surgical intervention
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTatar, Sedat
local.contributor.kuauthorYalçın, Can Ege
local.contributor.kuauthorSezgin, Billur
local.contributor.kuauthorTaş, Ayşe Yıldız
local.contributor.kuauthorMüftüoğlu, Orkun
local.contributor.kuauthorÖzmen, Selahattin
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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