Publication:
Mice monitor their timing errors

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentDepartment of Psychology
dc.contributor.departmentKUISCID (Koç University İşbank Center for Infectious Diseases)
dc.contributor.kuauthorÖztel, Tutku
dc.contributor.kuauthorBalcı, Fuat
dc.contributor.schoolcollegeinstituteCollege of Social Sciences and Humanities
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-03-06T21:00:27Z
dc.date.issued2024
dc.description.abstractAnimals often engage in representationally guided goal-directed behaviors. These behaviors are thus also subjected to representational uncertainty (e.g. timing uncertainty during waiting), which has been previously shown to adaptively guide behaviors normatively. These observations raise the question of whether non-human animals can track the direction and magnitude of their timing errors (i.e. temporal error monitoring). Only a few studies have investigated this question without addressing the key components of temporal error monitoring (e.g. due to differential reinforcement of metacognitive judgments and primary task representation). We conducted the critical test of temporal error monitoring in mice by developing a novel behavioral task that involved temporal production that exponentially favored temporal accuracy and minimized the contribution of sensorimotor noise. The response rate for an upcoming probabilistic reward following the timing performance was used as a proxy for confidence. We found that mice exhibited high reward expectancy after accurate and low reward expectancy after inaccurate timing performance. The reward expectancy decreased as a function of deviations from the target interval for the short and long reproductions;pointing to the symmetrical sensitivity of metacognition to shorter/longer than target responses. These findings suggest a complete temporal error monitoring ability for mice with human-like metacognitive features.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey-TUB and Idot;TAK (117K370) and NSERC Discovery (RGPIN-2021-03334) grants to FB.
dc.identifier.doi10.1038/s41598-024-71921-2
dc.identifier.grantnoScientific and Technological Research Council of Turkey-TUBIdot;TAK [117K370];NSERC Discovery [RGPIN-2021-03334]
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85205820183
dc.identifier.urihttps://doi.org/10.1038/s41598-024-71921-2
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27890
dc.identifier.volume14
dc.identifier.wos1330770000088
dc.keywordsTemporal error monitoring
dc.keywordsHigher order cognition
dc.keywordsAnimal behavior
dc.keywordsInterval timing
dc.keywordsResponse rate
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.subjectMultidisciplinary sciences
dc.titleMice monitor their timing errors
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÖztel, Tutku
local.contributor.kuauthorBalcı, Fuat
local.publication.orgunit1College of Social Sciences and Humanities
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Psychology
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUISCID (Koç University İşbank Center for Infectious Diseases)
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