Publication:
Invasive fungal infections after liver transplantation: a retrospective matched controlled risk analysis

dc.contributor.coauthorKaradağ, Halil İbrahim
dc.contributor.coauthorPapadakis, Marios
dc.contributor.coauthorPaul, Andreas
dc.contributor.coauthorÖzçelik, Arzu
dc.contributor.coauthorMalamutmann, Eugen
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAndaçoğlu, Oya Münevver
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T11:50:58Z
dc.date.issued2021
dc.description.abstractBackground: invasive fungal infections (IFI) are major risks for mortality after liver transplantation (LT). The aim of this study was to evaluate possible risk factors for the development of IFI after LT. Material and methods: all adult patients with IFI after LT between January 2012 and December 2016 at Essen University were identified. Pre-, intra-, and postoperative data were reviewed. These were compared to a 1-to-3 matched control group. Multinominal univariate and multivariate regression analyses were performed. Results: out of the 579 adults who underwent LT, 33 (5.6%) developed postoperative IFI. Fourteen had invasive aspergillosis with 7 (50%) mortality, and 19 had Candida sepsis with 7 (37%) mortality. The overall mortality due to invasive fungal infections was 42%. Perfusion fluid contamination with yeast was detected in 5 patients (15%). Multivariate regression analyses showed that preoperative dialysis (OR=1.163; CI: 1.038-1.302), Eurotransplant donor risk index (OR=0.04; CI=0.003-0.519), length of hospital stay (OR=25.074; CI: 23.99-26.208), and yeast contamination of the preservation fluid (OR=47.8; CI: 4.77-478, 96) were associated with IFI in the Candida group, whereas duration of surgery (OR=1.013; CI: 1.005-1.022), ventilation hours (OR=0.993; CI=0.986-0.999), and days of postoperative dialysis (OR=1.195; CI: 1.048-1,362) were associated with IFI in the aspergillosis group. Conclusions: post-LT IFI had 42% mortality in our cohort. Prophylactic antifungal therapy should be expanded to broader risk groups as defined above.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume26
dc.identifier.doi10.12659/AOT.930117
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03124
dc.identifier.issn1425-9524
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85112063904
dc.identifier.urihttps://doi.org/10.12659/AOT.930117
dc.identifier.wos683017300001
dc.keywordsAntifungal agents
dc.keywordsAspergillosis
dc.keywordsLiver transplantation
dc.keywordsAdult
dc.keywordsAged
dc.keywordsEnd stage liver disease
dc.keywordsFemale
dc.keywordsHumans
dc.keywordsInvasive fungal infections
dc.keywordsMale
dc.keywordsMiddle aged
dc.keywordsRetrospective studies
dc.keywordsRisk assessment
dc.keywordsSeverity of Illness Index
dc.language.isoeng
dc.publisherInternational Scientific Information (ISI)
dc.relation.grantnoNA
dc.relation.ispartofAnnals of Transplantation
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9784
dc.subjectSurgery
dc.subjectTransplantation
dc.titleInvasive fungal infections after liver transplantation: a retrospective matched controlled risk analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAndaçoğlu, Oya Münevver
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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