Publication:
Basal serum tryptase is not a risk factor for immediate-type drug hypersensitivity during childhood

dc.contributor.coauthorCavkaytar, Özlem
dc.contributor.coauthorKaraatmaca, Betül
dc.contributor.coauthorYılmaz, Ebru Arık
dc.contributor.coauthorŞahiner, Ümit Murat
dc.contributor.coauthorSekerel, Bülent Enis
dc.contributor.coauthorSoyer, Özge
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSaçkesen, Cansın
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:23:22Z
dc.date.issued2016
dc.description.abstractBackground: High serum basal tryptase (sBT) levels have been identified as a risk factor for both venom-and food-induced severe allergic reactions. The aim of this study was to compare sBT levels in children with different severity of actual drug hypersensitivity reactions (DHRs) with those of age-and sex-matched controls without any history of DHRs. Method: Patients between 0 and 18 years of age with a history of immediate-type DHRs manifested in 0-6 h after the culprit drug intake were included. Following ENDA (European Network for Drug Allergy) inquiries, patients were evaluated with skin and/or provocation tests to define the actual drug-hypersensitive patients. Serum BT levels were determined for both patients and controls. Results: of 345 children, 106 patients (30.7%) [(58.5% male), median age (interquartile range) 8.0 years (4.2-12.2)] were diagnosed as drug hypersensitive. Ninety-eight controls were also included. The sBT levels of drug-hypersensitive patients with and without anaphylaxis and the control group were similar [2.6 (2.0-3.6) lg/l vs. 2.8 (1.6-4.3) lg/l vs. 2.6 (1.8-3.6) lg/l, respectively, (p > 0.05)]. The sBT levels of the patients with sole cutaneous symptoms 2.8 (1.6-4.3) lg/l, mild anaphylaxis 3.0 (1.9-4.9) lg/l, and moderate-to-severe anaphylaxis 2.6 (2.0-3.6) lg/l were also comparable (p > 0.05). The onset of DHRs [those occurring in 1 h (n = 87) or in 1-6 h (n = 19) after the drug intake], positive results with skin tests with the culprit drug, or the classification of the patients according to different age groups [(0-2 years), (2-6 years), (6-12 years), (12-18 years)] did not correlate with sBT levels. Conclusion: The sBT levels in children with actual drug hypersensitivity would not be a risk factor for severe systemic reactions on the contrary to children with allergic reactions to food or insect venom.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipScientific Research Unit of Hacettepe University [014 D06 101 002-572] This study is supported by Scientific Research Unit of Hacettepe University (014 D06 101 002-572).
dc.description.volume27
dc.identifier.doi10.1111/pai.12604
dc.identifier.eissn1399-3038
dc.identifier.issn0905-6157
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84978823306
dc.identifier.urihttps://doi.org/10.1111/pai.12604
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11233
dc.identifier.wos387413900012
dc.keywordsAnaphylaxis
dc.keywordsDrug hypersensitivity
dc.keywordsPediatrics
dc.keywordsTryptase
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPediatric Allergy and Immunology
dc.subjectAllergy
dc.subjectImmunology
dc.subjectPediatrics
dc.titleBasal serum tryptase is not a risk factor for immediate-type drug hypersensitivity during childhood
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSaçkesen, Cansın
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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