Publication:
Flaxseed protects against diabetes-induced glucotoxicity by modulating pentose phosphate pathway and glutathione-dependent enzyme activities in rats

dc.contributor.coauthorGök, Müslüm
dc.contributor.coauthorTarhan, Nilay
dc.contributor.coauthorTufan, Can
dc.contributor.coauthorOzansoy, Gülgün
dc.contributor.coauthorArı, Nuray
dc.contributor.coauthorKarasu, Çimen
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:04:10Z
dc.date.issued2016
dc.description.abstractThis study investigated the effects of flaxseed (Linum usitatissimum L.) intake on general metabolism, pentose phosphate pathway (PPP) and glutathione-dependent enzymes in diabetic rats. Diabetes was induced by streptozotocin injection (40 mg/kg, i.p.) and the enzyme activities were determined spectrophotometrically. Diabetic and control rats were divided in two subgroups, one untreated, and one treated with flaxseed (0.714 g/kg body weight/day; orally) for 12 weeks. Flaxseed ameliorated decreased body weight (p <.05) and increased blood glucose (p <.001), triglyceride (p <.001), ALT (p <.001) and AST (p <.001) in diabetic rats. Diabetes resulted in increased glucose-6-phosphate dehydrogenase (G6PD) (p <.05) and decreased glutathione-S-transferase (GST) (p <.01), but unchanged 6-phosphogluconate dehydrogenase (6PGD) and glutathione reductase (GR) in the brain of rats. These alterations were partially improved by flaxseed in comparison to diabetic untreated group (p <.05). G6PD, 6PGD, GR were elevated (p <.001), while GST unchanged in the lung of diabetic untreated group compared to control. Flaxseed partially prevented the increase in 6PGD (p <.05) and GR (p <.01), but unaffected G6PD in the lung of diabetic rats. G6PD (p <.001), 6PGD (p <.05), GR (p <.001) were augmented, while GST showed a significant (p <.001) depletion in the pancreas of diabetic untreated rats compared to control. Diabetic alterations observed in pancreatic enzyme activities were significantly prevented by flaxseed. Furthermore, a remarkable decrease in 6PGD (p <.001) and an increase in G6PD (threefold of control) were found in the lens of diabetic untreated group that were completely prevented by flaxseed (p <.001). Flaxseed has beneficial effects against diabetes-induced glucotoxicity by modulating G6PD, 6PGD, GR and GST activities in tissues.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume13
dc.identifier.doi10.3109/19390211.2015.1036188
dc.identifier.issn1939-0211
dc.identifier.scopus2-s2.0-84948582126
dc.identifier.urihttps://doi.org/10.3109/19390211.2015.1036188
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8573
dc.keywordsDiabetic rat
dc.keywordsFlaxseed
dc.keywordsGlucotoxicity
dc.keywordsGlutathione-dependent enzymes
dc.keywordsPentose phosphate pathway
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Dietary Supplements
dc.subjectFood
dc.subjectScience
dc.subjectPharmacology
dc.subjectTherapeutics
dc.subjectMedicine
dc.subjectNutrition
dc.subjectDietetics
dc.titleFlaxseed protects against diabetes-induced glucotoxicity by modulating pentose phosphate pathway and glutathione-dependent enzyme activities in rats
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorUlusu, Nuriye Nuray
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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