Publication: Flaxseed protects against diabetes-induced glucotoxicity by modulating pentose phosphate pathway and glutathione-dependent enzyme activities in rats
dc.contributor.coauthor | Gök, Müslüm | |
dc.contributor.coauthor | Tarhan, Nilay | |
dc.contributor.coauthor | Tufan, Can | |
dc.contributor.coauthor | Ozansoy, Gülgün | |
dc.contributor.coauthor | Arı, Nuray | |
dc.contributor.coauthor | Karasu, Çimen | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ulusu, Nuriye Nuray | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:04:10Z | |
dc.date.issued | 2016 | |
dc.description.abstract | This study investigated the effects of flaxseed (Linum usitatissimum L.) intake on general metabolism, pentose phosphate pathway (PPP) and glutathione-dependent enzymes in diabetic rats. Diabetes was induced by streptozotocin injection (40 mg/kg, i.p.) and the enzyme activities were determined spectrophotometrically. Diabetic and control rats were divided in two subgroups, one untreated, and one treated with flaxseed (0.714 g/kg body weight/day; orally) for 12 weeks. Flaxseed ameliorated decreased body weight (p <.05) and increased blood glucose (p <.001), triglyceride (p <.001), ALT (p <.001) and AST (p <.001) in diabetic rats. Diabetes resulted in increased glucose-6-phosphate dehydrogenase (G6PD) (p <.05) and decreased glutathione-S-transferase (GST) (p <.01), but unchanged 6-phosphogluconate dehydrogenase (6PGD) and glutathione reductase (GR) in the brain of rats. These alterations were partially improved by flaxseed in comparison to diabetic untreated group (p <.05). G6PD, 6PGD, GR were elevated (p <.001), while GST unchanged in the lung of diabetic untreated group compared to control. Flaxseed partially prevented the increase in 6PGD (p <.05) and GR (p <.01), but unaffected G6PD in the lung of diabetic rats. G6PD (p <.001), 6PGD (p <.05), GR (p <.001) were augmented, while GST showed a significant (p <.001) depletion in the pancreas of diabetic untreated rats compared to control. Diabetic alterations observed in pancreatic enzyme activities were significantly prevented by flaxseed. Furthermore, a remarkable decrease in 6PGD (p <.001) and an increase in G6PD (threefold of control) were found in the lens of diabetic untreated group that were completely prevented by flaxseed (p <.001). Flaxseed has beneficial effects against diabetes-induced glucotoxicity by modulating G6PD, 6PGD, GR and GST activities in tissues. | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 3 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 13 | |
dc.identifier.doi | 10.3109/19390211.2015.1036188 | |
dc.identifier.issn | 1939-0211 | |
dc.identifier.scopus | 2-s2.0-84948582126 | |
dc.identifier.uri | https://doi.org/10.3109/19390211.2015.1036188 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/8573 | |
dc.keywords | Diabetic rat | |
dc.keywords | Flaxseed | |
dc.keywords | Glucotoxicity | |
dc.keywords | Glutathione-dependent enzymes | |
dc.keywords | Pentose phosphate pathway | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis | |
dc.relation.ispartof | Journal of Dietary Supplements | |
dc.subject | Food | |
dc.subject | Science | |
dc.subject | Pharmacology | |
dc.subject | Therapeutics | |
dc.subject | Medicine | |
dc.subject | Nutrition | |
dc.subject | Dietetics | |
dc.title | Flaxseed protects against diabetes-induced glucotoxicity by modulating pentose phosphate pathway and glutathione-dependent enzyme activities in rats | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ulusu, Nuriye Nuray | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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