Publication:
A new modality for the diagnosis of bleomycin-induced toxicity: ultrasonography

dc.contributor.coauthorDoğan, Coşkun
dc.contributor.coauthorComert, Sevda Şener
dc.contributor.coauthorSağmen, Seda Beyhan
dc.contributor.coauthorParmaksız, Elif Torun
dc.contributor.coauthorKıral, Nesrin
dc.contributor.coauthorFidan, Ali
dc.contributor.coauthorSalepci, Banu
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇağlayan, Benan Niku
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.yokid230719
dc.date.accessioned2024-11-09T23:30:11Z
dc.date.issued2018
dc.description.abstractObjective: To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary toxicity (BT). Material and methods: The study included patients with suspected BT during treatment with bleomycin due to various oncologic diseases between June 2015 and May 2017. The patients initially under-went clinical and high-resolution computed tomography (HRCT) examinations and pulmonary function tests (PFT)-diffusing capacity of the lung for carbon monoxide (DLCO), followed by registration of USG findings-number of comet tail artifact (CTA) images by a different pulmonologist. We compared the findings from USG, HRCT, and PFT-DLCO tests between BT and non-BT groups. With the diagnosis based on clinical-radiologic and PFT-DLCO assessments taken as the gold standard, we determined the sensitivity and specificity of the USG outcomes for diagnosis of BT. Results: The study included a total of 30 patients. Nine patients were diagnosed as having BT according to their clinical and radiologic findings and PFT-DLCO measurements. The mean number of CTA images was 68.7 +/- 22 in patients with BT vs 28.2 +/- 9.3 in those without BT (P < .001). The difference in CTA images between the patients with and without ground glass density was statistically significant (28.3 +/- 9.5 and 64.6 +/- 24.5, respectively, P < .001). In patients with BT, there was a negative correlation between the number of CTAs and DLCO% and FVC% values (P = .004; P = .016). USG had a sensitivity of 100%, and a specificity of 95% diagnosing BT in selected patients. Conclusion: In bleomycin-induced toxicity, USG findings are correlated with HRCT and PFT-DLCO findings, with a remarkably increased number of CTAs in BT. Thoracic USG examination is a diagnostic tool with a high sensitivity and specificity for diagnosing BT. / Objetivo: evaluar el papel de la ecografia en el diagnostico de la toxicidad pulmonar inducida por bleomicina (BT). Materiales y metodos: se incluyeron pacientes con sospecha de BT durante el tratamiento con bleomicina por enfermedad oncologica entre junio de 2015 y mayo de 2017. Se les sometio a evaluacion clínica inicial y tomografia computarizada de alta resolucion (TACAR), asi como a pruebas de funcion pulmonar (PFP, prueba de difusion de monoxido de carbono [DLCO]). Se recopilaron los hallazgos ecograficos obtenidos por otro neumologo (numero de imagenes de artefacto en cola de cometa [CTA]). Se compararon los resultados de las ecografias, TACAR y PFP–DLCO entre los grupos con y sin BT. Con el diagnostico basado en las valoraciones clínico-radiologicas y de PFP–DLCO como gold standard, se determino la sensibilidad y especificidad de la ecografia para diagnosticar BT. Resultados: Se incluyeron 30 pacientes. Se diagnostico BT en nueve por los hallazgos clinicos y radiologicos y de PFP–DLCO. El numero medio de imagenes CTA fue 68.7 ± 22 en pacientes con BT vs. 28.2 ± 9.3 en aquellos sin BT (p < 0.001). La diferencia en imagenes CTAentre los pacientes con y sin densidades en vidrio esmerilado fue estadisticamente significativa (28.3 ± 9.5 and 64.6 ± 24.5, respectivamente, p < 0.001). En pacientes con BT, se observo una correlacion negativa entre el numero de CTA y los valores porcentuales de DLCO y de CVF (p = 0.004; p = 0.016). La USG tuvo una sensibilidad del 100% y una especificidad del 95% para el diagnostico de la BT en pacientes seleccionados. Conclusion: En la toxicidad inducida por bleomicina, los hallazgos de US se correlacionan con los de TACAR y PFT–DLCO, con un incremento remarcable en el numero de CTA en BT. La exploracion toracica mediante USG es una herramienta de diagnostico con elevada sensibilidad y especificidad para el diagnostico de la BT.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue12
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume54
dc.identifier.doi10.1016/j.arbres.2018.06.006
dc.identifier.eissn1579-2129
dc.identifier.issn0300-2896
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85056881599
dc.identifier.urihttp://dx.doi.org/10.1016/j.arbres.2018.06.006
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12170
dc.identifier.wos451934300007
dc.keywordsBleomycin toxicity
dc.keywordsHigh-resolution computed tomography
dc.keywordsUltrasonography / Toxicidad a bleomicina
dc.keywordsTomografia computarizada de alta resolucion
dc.keywordsEcografia
dc.languageEnglish
dc.publisherElsevier Doyma Sl
dc.sourceArchivos De Bronconeumologia
dc.subjectRespiratory system
dc.titleA new modality for the diagnosis of bleomycin-induced toxicity: ultrasonography
dc.title.alternativeNuevo metodo diagnostico para la toxicidad inducida por bleomicina: la ecografia
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-6131-157X
local.contributor.kuauthorÇağlayan, Benan Niku
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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