Publication:
Progress Study: progression of chronic kidney disease in children and heat shock proteins

dc.contributor.coauthorYürük Yıldırım, Zeynep Nagehan
dc.contributor.coauthorUsta Akgül, Sebahat
dc.contributor.coauthorAlpay, Harika
dc.contributor.coauthorAksu, Bağdagül
dc.contributor.coauthorSavran Oğuz, Fatma
dc.contributor.coauthorKıyak, Aysel
dc.contributor.coauthorAkıncı, Nurver
dc.contributor.coauthorYavuz, Sevgi
dc.contributor.coauthorÖzçelik, Gül
dc.contributor.coauthorGedikbaşı, Asuman
dc.contributor.coauthorGökçe, İbrahim
dc.contributor.coauthorÖzkayın, Neşe
dc.contributor.coauthorYıldız, Nurdan
dc.contributor.coauthorPehlivanoğlu, Cemile
dc.contributor.coauthorGöknar, Nilüfer
dc.contributor.coauthorSaygılı, Seha
dc.contributor.coauthorTülpar, Sebahat
dc.contributor.coauthorKüçük, Nuran
dc.contributor.coauthorAğbaş, Ayşe
dc.contributor.coauthorDirican, Ahmet
dc.contributor.coauthorEmre, Sevinç
dc.contributor.coauthorNayir, Ahmet
dc.contributor.coauthorYolmaz, Alev
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBilge, İlmay
dc.contributor.kuauthorTaşdemir, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:10:33Z
dc.date.issued2021
dc.description.abstractVarious molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.volume26
dc.identifier.doi10.1007/s12192-021-01239-9
dc.identifier.eissn1466-1268
dc.identifier.issn1355-8145
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85117421252
dc.identifier.urihttps://doi.org/10.1007/s12192-021-01239-9
dc.identifier.urihttps://hdl.handle.net/20.500.14288/17330
dc.identifier.wos709220700001
dc.keywordsChronic kidney disease
dc.keywordsCKD
dc.keywordsHeat shock protein
dc.keywordsHSP
dc.keywordsProgression HSP70
dc.keywordsExpression
dc.keywordsCells
dc.keywordsDegradation
dc.keywordsChaperones
dc.keywordsApoptosis
dc.keywordsFibrosis
dc.keywordsMarker
dc.keywordsDamage
dc.keywordsHSP47
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.grantnoScientific and Technological Research Council of Turkey (TUBITAK) within 1001-Scientific and Technological Research Projects Funding Program [115S365] Y This study was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) within 1001-Scientific and Technological Research Projects Funding Program (project number:115S365).
dc.relation.ispartofCell Stress and Chaperones
dc.subjectCell Biology
dc.titleProgress Study: progression of chronic kidney disease in children and heat shock proteins
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBilge, İlmay
local.contributor.kuauthorTaşdemir, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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