Publication: Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior
dc.contributor.coauthor | N/A | |
dc.contributor.department | Department of Chemistry | |
dc.contributor.department | Department of Chemistry | |
dc.contributor.department | Department of Chemistry | |
dc.contributor.kuauthor | Fael, Hanan | |
dc.contributor.kuauthor | Demirel, Adem Levent | |
dc.contributor.kuprofile | Researcher | |
dc.contributor.kuprofile | Faculty Member | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.contributor.yokid | N/A | |
dc.contributor.yokid | 6568 | |
dc.date.accessioned | 2024-11-09T23:29:41Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Co-amorphous systems have been increasingly investigated to improve the solubility and dissolution rate of poorly soluble drugs. Considering the ability of tannic acid (TA), a polyphenolic compound, to form hydrogen bonds with compounds that contain carbonyl groups, we hypothesized that tannic acid will also be effective in stabilizing amorphous form of drugs in co-amorphous systems. Co-amorphization by TA of two poorly soluble model drugs, carbamazepine (CBZ) and indomethacin (IND) was investigated. Tannic acid facilitated the amorphization of studied drugs and successful co-amorphous systems were obtained as proved by powder X-Ray diffraction (PXRD). Differential scanning calorimetry (DSC) confirmed the homogeneous structure as indicated by the existence of a single T-g for each co-amorphous product. The expected molecular interactions between phenolic groups in TA and carbonyl groups in the studied drugs (CBZ and IND) were confirmed by analyzing their infrared spectra. Drug-TA co-amorphous formulations showed an enhanced equilibrium solubility over the individual drugs. Powder dissolution WA under sink conditions showed improved dissolution profiles of drug-TA co-amorphous formulations compared to the corresponding crystalline drugs and physical mixtures. Tannic acid also showed a superior stabilizing effect. CBZ-TA co-amorphous system was physically stable at dry conditions (up to 6 months at 40 degrees C), under 60% relative humidity (up to one month at 20 degrees C), and in solution (after 48 h of solubility measurements), as revealed by PXRD examination of the remaining solid after solubility measurement. However, IND-TA co-amorphous formulation remained stable at dry conditions up to 6 months at 4 degrees C and up to one month at 60% relative humidity at 20 degrees C. These findings demonstrate the potential of tannic acid as a promising co-former in co-amorphous systems of poorly soluble drugs. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.openaccess | NO | |
dc.description.sponsorship | Koc University | |
dc.description.sponsorship | Institute of International Education Hanan Fael acknowledges the postdoctoral research support from Institute of International Education and Koc University. The authors thank KUYTAM (Koc University Surface Technologies Research Center) for PXRD characterizations. | |
dc.description.volume | 581 | |
dc.identifier.doi | 10.1016/j.ijpharm.2020.119284 | |
dc.identifier.eissn | 1873-3476 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.scopus | 2-s2.0-85082762212 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.ijpharm.2020.119284 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/12098 | |
dc.identifier.wos | 531566600009 | |
dc.keywords | Tannic acid | |
dc.keywords | Co-former | |
dc.keywords | Co-amorphous system | |
dc.keywords | Poorly soluble drugs | |
dc.keywords | Stability | |
dc.keywords | Solubility | |
dc.keywords | Dissolution glass-transition temperature | |
dc.keywords | Drug-delivery systems | |
dc.keywords | Binary-systems | |
dc.keywords | Indomethacin | |
dc.keywords | Carbamazepine | |
dc.keywords | Salt | |
dc.keywords | Crystallization | |
dc.keywords | Transformation | |
dc.keywords | Combination | |
dc.keywords | Formulation | |
dc.language | English | |
dc.publisher | Elsevier | |
dc.source | International Journal Of Pharmaceutics | |
dc.subject | Pharmacology | |
dc.subject | Pharmacy | |
dc.title | Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.authorid | 0000-0002-6190-1190 | |
local.contributor.authorid | 0000-0002-1809-1575 | |
local.contributor.kuauthor | Fael, Hanan | |
local.contributor.kuauthor | Demirel, Adem Levent | |
relation.isOrgUnitOfPublication | 035d8150-86c9-4107-af16-a6f0a4d538eb | |
relation.isOrgUnitOfPublication.latestForDiscovery | 035d8150-86c9-4107-af16-a6f0a4d538eb |