Publication:
Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior

dc.contributor.coauthorN/A
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentDepartment of Chemistry
dc.contributor.kuauthorFael, Hanan
dc.contributor.kuauthorDemirel, Adem Levent
dc.contributor.kuprofileResearcher
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.yokidN/A
dc.contributor.yokid6568
dc.date.accessioned2024-11-09T23:29:41Z
dc.date.issued2020
dc.description.abstractCo-amorphous systems have been increasingly investigated to improve the solubility and dissolution rate of poorly soluble drugs. Considering the ability of tannic acid (TA), a polyphenolic compound, to form hydrogen bonds with compounds that contain carbonyl groups, we hypothesized that tannic acid will also be effective in stabilizing amorphous form of drugs in co-amorphous systems. Co-amorphization by TA of two poorly soluble model drugs, carbamazepine (CBZ) and indomethacin (IND) was investigated. Tannic acid facilitated the amorphization of studied drugs and successful co-amorphous systems were obtained as proved by powder X-Ray diffraction (PXRD). Differential scanning calorimetry (DSC) confirmed the homogeneous structure as indicated by the existence of a single T-g for each co-amorphous product. The expected molecular interactions between phenolic groups in TA and carbonyl groups in the studied drugs (CBZ and IND) were confirmed by analyzing their infrared spectra. Drug-TA co-amorphous formulations showed an enhanced equilibrium solubility over the individual drugs. Powder dissolution WA under sink conditions showed improved dissolution profiles of drug-TA co-amorphous formulations compared to the corresponding crystalline drugs and physical mixtures. Tannic acid also showed a superior stabilizing effect. CBZ-TA co-amorphous system was physically stable at dry conditions (up to 6 months at 40 degrees C), under 60% relative humidity (up to one month at 20 degrees C), and in solution (after 48 h of solubility measurements), as revealed by PXRD examination of the remaining solid after solubility measurement. However, IND-TA co-amorphous formulation remained stable at dry conditions up to 6 months at 4 degrees C and up to one month at 60% relative humidity at 20 degrees C. These findings demonstrate the potential of tannic acid as a promising co-former in co-amorphous systems of poorly soluble drugs.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.sponsorshipKoc University
dc.description.sponsorshipInstitute of International Education Hanan Fael acknowledges the postdoctoral research support from Institute of International Education and Koc University. The authors thank KUYTAM (Koc University Surface Technologies Research Center) for PXRD characterizations.
dc.description.volume581
dc.identifier.doi10.1016/j.ijpharm.2020.119284
dc.identifier.eissn1873-3476
dc.identifier.issn0378-5173
dc.identifier.scopus2-s2.0-85082762212
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijpharm.2020.119284
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12098
dc.identifier.wos531566600009
dc.keywordsTannic acid
dc.keywordsCo-former
dc.keywordsCo-amorphous system
dc.keywordsPoorly soluble drugs
dc.keywordsStability
dc.keywordsSolubility
dc.keywordsDissolution glass-transition temperature
dc.keywordsDrug-delivery systems
dc.keywordsBinary-systems
dc.keywordsIndomethacin
dc.keywordsCarbamazepine
dc.keywordsSalt
dc.keywordsCrystallization
dc.keywordsTransformation
dc.keywordsCombination
dc.keywordsFormulation
dc.languageEnglish
dc.publisherElsevier
dc.sourceInternational Journal Of Pharmaceutics
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleTannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-6190-1190
local.contributor.authorid0000-0002-1809-1575
local.contributor.kuauthorFael, Hanan
local.contributor.kuauthorDemirel, Adem Levent
relation.isOrgUnitOfPublication035d8150-86c9-4107-af16-a6f0a4d538eb
relation.isOrgUnitOfPublication.latestForDiscovery035d8150-86c9-4107-af16-a6f0a4d538eb

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