Publication:
Differences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States

dc.contributor.coauthorGarcia, Cristina Cano
dc.contributor.coauthorNimer, Nancy
dc.contributor.coauthorPiccinelli, Mattia Luca
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorPanunzio, Andrea
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorKapoor, Anil
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorAntonelli, Alessandro
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorKluth, Luis A.
dc.contributor.coauthorBecker, Andreas
dc.contributor.coauthorChun, Felix K. H.
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:40:53Z
dc.date.issued2023
dc.description.abstractPurpose: To quantify differences in five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age-and sex-matched population-based controls, especially when race/ethnicity is considered. Methods: We relied on the Surveillance, Epidemiology and End Results database (2006-2016) to iden-tify newly diagnosed (2006-2011) ccmRCC patients of either Caucasian, Hispanic, African American, or Asian/Pacific Islander race/ethnicity. For each case, we simulated an age-and sex-matched control (Monte Carlo simulation), relying on Social Security Administration Life Tables with five-year follow-up. We compared OS between ccmRCC patients and controls. Multivariable Cox regression models tested for race/ethnicity effect on OS. Results: Of 3067 ccmRCC patients, 2167 (71%) were Caucasians vs. 488 (16%) Hispanics vs. 216 (7%) African Americans and 196 (6%) Asians/Pacific Islanders. At five years, OS difference between ccmRCC patients vs. population-based controls was greatest in African Americans (11 vs. 94%, A = 84%), followed by Hispanics (16 vs. 94%, A = 77%), Caucasians (16 vs. 89%, A = 73%) and Asians/Pacific Islanders (19 vs. 88%, A = 70%). In multivariable Cox regression models, African Americans exhibited highest Hazard Ratio for death (HR 1.3, p = 0.003).
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipCristina Cano Garcia was awarded a scholarship by the STIFTUNG GIERSCH.
dc.description.volume79
dc.identifier.doi10.1016/j.annepidem.2023.01.003
dc.identifier.eissn1873-2585
dc.identifier.issn1047-2797
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85146852640
dc.identifier.urihttps://doi.org/10.1016/j.annepidem.2023.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23476
dc.identifier.wos991675700001
dc.keywordsSEER
dc.keywordsSocial security administration
dc.keywordsMetastatic renal cell carcinoma
dc.keywordsLife tables
dc.keywordsRace
dc.keywordsEthnicity
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.grantnoSTIFTUNG GIERSCH
dc.relation.ispartofAnnals of Epidemiology
dc.subjectPublic
dc.subjectEnvironmental
dc.subjectOccupational health
dc.titleDifferences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

Files