Publication:
Hydrogen sulfide responsive phototherapy agents: design strategies and biological applications

dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorKölemen, Safacan
dc.contributor.kuauthorDırak, Musa
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2025-01-19T10:30:17Z
dc.date.issued2023
dc.description.abstractHydrogen sulfide (H2S) is one of the criticalgasotransmitters,which play important roles in regular physiological processes, especiallyin vital signaling pathways. However, fluctuations in endogenous H2S concentration can be linked to serious health problems,such as neurodegenerative diseases, cancer, diabetes, inflammation,cardiovascular diseases, and hypertension. Thus, it has attracteda great deal of attention in therapeutic applications, specificallyin the field of phototherapy. Photodynamic therapy (PDT) and photothermaltherapy (PTT) are two subclasses of phototherapy, which utilize eitherreactive oxygen species (ROS) or local temperature increase upon irradiationof a photosensitizer (PS) to realize the therapeutic action. Phototherapiesoffer unique advantages compared to conventional methods; thus, theyare highly promising and popular. One of the design principles followedin new generation PSs is to build activity-based PSs, which stay inactivebefore getting activated by disease-associated stimuli. These activatablePSs dramatically improve the selectivity and efficacy of the therapy.In this review, we summarize small molecule and nanomaterial-basedPDT and PTT agents that are activated selectively by H2S to initiate their cytotoxic effect. We incorporate single modePDT and PTT agents along with synergistic and/or multimodal photosensitizersthat can combine more than one therapeutic approach. Additionally,H2S-responsive theranostic agents, which offer therapyand imaging at the same time, are highlighted. Design approaches,working principles, and biological applications for each example arediscussed in detail.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessGreen Published, gold
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe authors thank Ayca Saymaz for the design of the graphical abstract and Figures 1 and 2, which were created with BioRender.com. S.K. thanks the Turkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program, for the financial support.
dc.description.volume3
dc.identifier.doi10.1021/acsbiomedchemau.3c00028
dc.identifier.eissn2694-2437
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85164495665
dc.identifier.urihttps://doi.org/10.1021/acsbiomedchemau.3c00028
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26028
dc.identifier.wos1049346900001
dc.keywordsCancer
dc.keywordsPhototherapy
dc.keywordsBioimaging
dc.keywordsTheranostics
dc.keywordsHydrogen sulfide
dc.keywordsPhotosensitizers
dc.keywordsActivity-based agents
dc.keywordsMultimodal therapy
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.grantnoTurkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program
dc.relation.ispartofACS Bio and Med Chem Au
dc.subjectBiochemistry and molecular biology
dc.subjectChemistry, medicinal
dc.titleHydrogen sulfide responsive phototherapy agents: design strategies and biological applications
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorDırak, Musa
local.contributor.kuauthorTuran, Sarp Emre
local.contributor.kuauthorKölemen, Safacan
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Department of Chemistry Department of Chemistry
local.publication.orgunit2Graduate School of Sciences and Engineering
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