Publication:
WGO guidance for the care of patients with COVID-19 and liver disease

dc.contributor.coauthorHamid, Saeed
dc.contributor.coauthorAlvares da Silva, Mario R.
dc.contributor.coauthorBurak, Kelly W.
dc.contributor.coauthorChen, Tao
dc.contributor.coauthorDrenth, Joost P. H.
dc.contributor.coauthorEsmat, Gamal
dc.contributor.coauthorGaspar, Rui
dc.contributor.coauthorLaBrecque, Douglas
dc.contributor.coauthorLee, Alice
dc.contributor.coauthorMacedo, Guilherme
dc.contributor.coauthorMcMahon, Brian
dc.contributor.coauthorNing, Qin
dc.contributor.coauthorReau, Nancy
dc.contributor.coauthorSonderup, Mark
dc.contributor.coauthorvan Leeuwen, Dirk J.
dc.contributor.coauthorArmstrong, David
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorYurtaydın, Süleyman Cihan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:02:29Z
dc.date.issued2021
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the least deadly but most infectious coronavirus strain transmitted from wild animals. It may affect many organ systems. Aim of the current guideline is to delineate the effects of SARS-CoV-2 on the liver. Asymptomatic aminotransferase elevations are common in coronavirus disease 2019 (COVID-19) disease. Its pathogenesis may be multifactorial. It may involve primary liver injury and indirect effects such as "bystander hepatitis," myositis, toxic liver injury, hypoxia, and preexisting liver disease. Higher aminotransferase elevations, lower albumin, and platelets have been reported in severe compared with mild COVID-19. Despite the dominance of respiratory disease, acute on chronic liver disease/acute hepatic decompensation have been reported in patients with COVID-19 and preexisting liver disease, in particular cirrhosis. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a higher risk of respiratory disease progression than those without MAFLD. Alcohol-associated liver disease may be severely affected by COVID-19-such patients frequently have comorbidities including metabolic syndrome and smoking-induced chronic lung disease. World Gastroenterology Organization (WGO) recommends that interventional procedures such as endoscopy and endoscopic retrograde cholangiopancreatography should be performed in emergency cases or when they are considered strictly necessary such as high risk varices or cholangitis. Hepatocellular cancer surveillance may be postponed by 2 to 3 months. A short delay in treatment initiation and non-surgical approaches should be considered. Liver transplantation should be restricted to patients with high MELD scores, acute liver failure and hepatocellular cancer within Milan criteria. Donors and recipients should be tested for SARS-CoV-2 and if found positive donors should be excluded and liver transplantation postponed until recovery from infection.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume55
dc.identifier.doi10.1097/MCG.0000000000001459
dc.identifier.eissn1539-2031
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02668
dc.identifier.issn0192-0790
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85096645884
dc.identifier.urihttps://hdl.handle.net/20.500.14288/988
dc.identifier.wos599709300002
dc.keywordsCOVID-19 disease
dc.keywordsLiver disease
dc.keywordsChronic viral hepatitis
dc.keywordsMetabolic dysfunction-associated liver disease
dc.keywordsAutoimmune liver diseases
dc.keywordsHepatocellular carcinoma
dc.keywordsLiver transplantation
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins (LWW)
dc.relation.grantnoNA
dc.relation.ispartofJournal of Clinical Gastroenterology
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9313
dc.subjectMedicine
dc.subjectGastroenterology
dc.subjectHepatology
dc.titleWGO guidance for the care of patients with COVID-19 and liver disease
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYurtaydın, Süleyman Cihan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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